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Nucleoporin 214kDa

CAN, Cain, NUP214
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, V1a, CsA, ACID, AGE
Papers using CAN antibodies
Cell-cycle-dependent dynamics of nuclear pores: pore-free islands and lamins.
Klymkowsky Michael, In PLoS ONE, 2005
... Antibodies to NUP214 were purchased from Bethyl Laboratories (product numbers IHC-00103 ...
Imaging kinase–AKAP79–phosphatase scaffold complexes at the plasma membrane in living cells using FRET microscopy
Dell'Acqua Mark L. et al., In The Journal of Cell Biology, 2000
... The coding sequences for AKAP79WT, (1–153), ΔPKA(1–361), ΔCaN(Δ315–360), or the 321–360 CaN binding fragment were subcloned into pEGFPN1 (CLONTECH Laboratories, Inc.) as previously ...
Papers on CAN
The involvement of TRPC1 in skeletal muscle regrowth after unloading-induced atrophy.
Yeung et al., Hong Kong, Hong Kong. In J Physiol, Feb 2016
Additionally, inhibition of calcineurin (CaN) activity downregulated TRPC1 expression in both weight-bearing and reloaded muscles suggesting a possible association between CaN and TRPC1 during skeletal muscle regrowth.
Phenylephrine promotes cardiac fibroblast proliferation through calcineurin-NFAT pathway.
Zhu et al., Nantong, China. In Front Biosci, Dec 2015
Ca(2+)/calmodulin-dependent calcineurin (CaN) plays an important role in various Ca(+2) signaling pathways, among which are those involved in cardiac diseases.
Effects of immunological challenge induced by lipopolysaccharide on skeletal muscle fiber type conversion of piglets.
Peng et al., In J Anim Sci, Nov 2015
Compared with those in the control group, transcriptional peroxisome proliferator-activated receptor coactivator-α () mRNA ( < 0.05), calcineurin (CaN) mRNA, and protein expression were reduced ( < 0.05), and PGC-α protein expression tended to be reduced ( = 0.08) in the LM of LPS-challenged piglets.
Mesenchymal stem cells suppress CaN/NFAT expression in the pulmonary arteries of rats with pulmonary hypertension.
He et al., Guiyang, China. In Exp Ther Med, Nov 2015
The present study determined that mesenchymal stem cells (MSCs) suppress the expression of calcineurin (CaN) and nuclear factor of activated T-cells (NFAT) in the pulmonary arteries of rats, and this may exert a therapeutic effect on PH.
Struijk et al., Amsterdam, Netherlands. In Perit Dial Int, Nov 2015
In this review, it will be argued that free water transport can be used for assessment of fibrotic peritoneal alterations, due to the water-binding capacity of collagen.
[Role of calcineurin-nuclear factor of activated T cells signaling pathway in myoblast apoptosis induced by cyclic tensile strain].
Yuan et al., In Hua Xi Kou Qiang Yi Xue Za Zhi, Oct 2015
OBJECTIVE: This study investigated the role and mechanism of calcineurin (CaN)-nuclear factor of activated T cells (NFAT) pathway in the myoblast apoptosis induced by cyclic tensile strain.
Diabetic Neuropathies
Nevoret et al., Madagascar. In Unknown Journal, Sep 2015
Painful DN can be difficult to treat, and is associated with reduced quality of life, poor sleep, depression and anxiety.
Evolutionary and functional perspectives on signaling from neuronal surface to nucleus.
Ma et al., New York City, United States. In Biochem Biophys Res Commun, May 2015
This intricate pathway depends on a specific role for multiple Ca(2+)/CaM-dependent kinases and phosphatases: α/βCaMKII phosphorylates γCaMKII to trap CaM; CaN dephosphorylates γCaMKII to dispatch it to the nucleus; and PP2A induces CaM release from γCaMKII so that CaMKK and CaMKIV can trigger CREB phosphorylation.
Diabetic cardiac autonomic neuropathy: Do we have any treatment perspectives?
Serhiyenko et al., L'viv, Ukraine. In World J Diabetes, Apr 2015
Cardiac autonomic neuropathy (CAN) is a serious and common complication of diabetes mellitus (DM).
Identification of Putative Natriuretic Hormones Isolated from Human Urine.
Kramer, Bonn, Germany. In Front Endocrinol (lausanne), 2014
In a similar study, Cain et al. (4) isolated a sodium transport inhibitor from the urine of uremic patients by gel chromatography and RP-HPLC.
γCaMKII shuttles Ca²⁺/CaM to the nucleus to trigger CREB phosphorylation and gene expression.
Tsien et al., New York City, United States. In Cell, 2014
We show that the shuttle protein is γCaMKII, its phosphorylation at Thr287 by βCaMKII protects the Ca(2+)/CaM signal, and CaN triggers its nuclear translocation.
Regulation of inflammatory responses and fibroblast-like synoviocyte apoptosis by calcineurin-binding protein 1 in mice with collagen-induced arthritis.
Ryoo et al., Taegu, South Korea. In Arthritis Rheum, 2012
Our findings demonstrate that hCABIN-1 plays a critical role in promoting apoptosis of fibroblast-like synoviocytes and in attenuating inflammation and cartilage and bone destruction in rheumatoid arthritis.
Identification of an ubinuclein 1 region required for stability and function of the human HIRA/UBN1/CABIN1/ASF1a histone H3.3 chaperone complex.
Marmorstein et al., Philadelphia, United States. In Biochemistry, 2012
NHRD domain of UBN1 as being an essential region for HIRA interaction and chromatin organization by the HUCA complex
Phenotypic and genetic characterization of adult T-cell acute lymphoblastic leukemia with del(9)(q34);SET-NUP214 rearrangement.
Min et al., Seoul, South Korea. In Ann Hematol, 2012
Data describe the relatively high incidence of SET-NUP214 rearrangement in adult T-ALLs, and demonstrate comprehensive clinical, phenotypic, and genetic characteristics of this entity.
Nuclear distributions of NUP62 and NUP214 suggest architectural diversity and spatial patterning among nuclear pore complexes.
Kohtz et al., New York City, United States. In Plos One, 2011
Nucleoporin p62 (NUP62) and nucleoporin 214 (NUP214) are differentially distributed between nuclear pore complexes.
Human CABIN1 is a functional member of the human HIRA/UBN1/ASF1a histone H3.3 chaperone complex.
Adams et al., Bearsden, United Kingdom. In Mol Cell Biol, 2011
Data show that, like HIRA, UBN1, and ASF1a, CABIN1 is involved in heterochromatinization of the genome of senescent human cells.
A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export.
Weis et al., Berkeley, United States. In Nature, 2011
Dbp5 is localized to the NPC via an interaction with Nup159 (NUP214 in vertebrates) and is locally activated there by Gle1 together with the small-molecule inositol hexakisphosphate (InsP(6)).
Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia.
Cools et al., Leuven, Belgium. In Nat Genet, 2010
Deletion of PTPN2 was specifically found in T-ALLs with aberrant expression of the TLX1 transcription factor oncogene, including four cases also expressing the NUP214-ABL1 tyrosine kinase.
TRPM4 regulates calcium oscillations after T cell activation.
Kinet et al., Boston, United States. In Science, 2004
TRPM4 has recently been described as a calcium-activated nonselective (CAN) cation channel that mediates membrane depolarization.
Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia.
Hagemeijer et al., Leuven, Belgium. In Nat Genet, 2004
NUP214-ABL1 expression defines a new subgroup of individuals with T-ALL
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