Microtubule minus-end-targeting proteins.
Utrecht, Netherlands. In Curr Biol, Mar 2015
The recent characterization of the CAMSAP/Patronin/Nezha family members as specific 'minus-end-targeting proteins' ('-TIPs') has provided important new insights into the mechanisms governing minus-end dynamics.
Regulation of microtubule minus-end dynamics by CAMSAPs and Patronin.
San Francisco, United States. In Proc Natl Acad Sci U S A, 2014
A variety of proteins act on MT ends to regulate their dynamics, including a recently described family of MT minus-end binding proteins called calmodulin-regulated spectrin-associated protein (CAMSAP)/Patronin/Nezha. Patronin, the single member of this family in Drosophila, was previously shown to stabilize MT minus-ends against depolymerization in vitro and in vivo.
CAMSAPs add to the growing microtubule minus-end story.
Bethlehem, United States. In Dev Cell, 2014
(2014) in this issue of Developmental Cell shows how mammalian CAMSAP proteins stabilize minus ends, providing a key piece to the puzzle of how these minus ends are formed and stabilized.