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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta

Top mentioned proteins: AMPK, HAD, POLYMERASE, V1a, CAN
Papers on CAMKK2
Polymorphisms in CAMKK2 may predict sensory neuropathy in African HIV patients.
Price et al., Perth, Australia. In J Neurovirol, Feb 2016
Here, we assess the impact of single-nucleotide polymorphisms (SNPs) in a cluster of three genes that affect inflammation and neuronal repair: P2X7R, P2X4R and CAMKK2.
The Early Effects of Rapid Androgen Deprivation on Human Prostate Cancer.
Neal et al., Cambridge, United Kingdom. In Eur Urol, Dec 2015
We observed differential expression of known androgen-regulated genes (TMPRSS2, KLK3, CAMKK2, FKBP5).
A genetic variant in CAMKK2 gene is possibly associated with increased risk of bipolar disorder.
Darvish et al., Tehrān, Iran. In J Neural Transm, Oct 2015
UNASSIGNED: A recent large-scale study have reported that rs1063843, a single nucleotide polymorphism located in the CAMKK2 gene is highly associated with schizophrenia in European and Han Chinese populations.
Activation of Adenosine Monophosphate-Activated Protein Kinase Is an Additional Mechanism That Participates in Mediating Inhibitory Actions of Prostaglandin F2Alpha in Mature, but Not Developing, Bovine Corpora Lutea.
Flores et al., Morgantown, United States. In Biol Reprod, Jul 2015
The objectives of this study were to determine 1) if calcium/calmodulin-dependent kinase kinase 2 (CAMKK2) participates in mediating PGF2alpha actions in developing (Day [d]-4) and mature (d-10) bovine corpus luteum (CL), 2) distal targets of CAMKK2, 3) developmental expression of adenosine monophosphate-activated protein kinase (AMPK), and 4) effects of AMPK activation on progesterone (P4) production.
Sorafenib synergizes with metformin in NSCLC through AMPK pathway activation.
Bernards et al., Amsterdam, Netherlands. In Int J Cancer, Apr 2015
Here, we identify sorafenib as an activator of AMP-activated protein kinase (AMPK), in a manner that involves either upstream LKB1 or CAMKK2.
MicroRNA-224 and its target CAMKK2 synergistically influence tumor progression and patient prognosis in prostate cancer.
Zhong et al., Guangzhou, China. In Tumour Biol, Mar 2015
In this study, calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) was identified as a target gene of miR-224.
The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML.
Jacquel et al., Nice, France. In Autophagy, 2014
Here we show that the CAMKK2-PRKAA1-ULK1 pathway is required for CSF1-induced autophagy and human monocyte differentiation.
Calcium calmodulin dependent kinase kinase 2 - a novel therapeutic target for gastric adenocarcinoma.
Chatterjee et al., Bengaluru, India. In Cancer Biol Ther, 2014
Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) was found to be 7-fold overexpressed in gastric tumor tissues.
Thyroid hormone induction of mitochondrial activity is coupled to mitophagy via ROS-AMPK-ULK1 signaling.
Yen et al., Singapore, Singapore. In Autophagy, 2014
We show that T3 induction of ROS activates CAMKK2 (calcium/calmodulin-dependent protein kinase kinase 2, β) mediated phosphorylation of PRKAA1/AMPK (5' AMP-activated protein kinase), which in turn phosphorylates ULK1 (unc-51 like autophagy activating kinase 1) leading to its mitochondrial recruitment and initiation of mitophagy.
TRPM3 and miR-204 establish a regulatory circuit that controls oncogenic autophagy in clear cell renal cell carcinoma.
Czyzyk-Krzeska et al., Cincinnati, United States. In Cancer Cell, 2014
Increased expression of TRPM3 in RCC leads to Ca(2+) influx, activation of CAMKK2, AMPK, and ULK1, and phagophore formation.
The novel regulations of MEF2A, CAMKK2, CALM3, and TNNI3 in ventricular hypertrophy induced by arsenic exposure in rats.
Lin et al., Taipei, Taiwan. In Toxicology, 2014
Collectively, based on our real-time PCR and western blot data strongly suggest that calcium homeostasis may also go through MEF2A, TNNI3, CAMKK2, CALM3 and cardiac hypertrophy relative signaling pathway.
Convergent lines of evidence support CAMKK2 as a schizophrenia susceptibility gene.
Gan et al., Hangzhou, China. In Mol Psychiatry, 2014
We found calcium/calmodulin (CAM)-dependent protein kinase kinase 2 (CAMKK2) is significantly downregulated in individuals with schizophrenia in both studies.
microRNA-9 attenuates amyloidβ-induced synaptotoxicity by targeting calcium/calmodulin-dependent protein kinase kinase 2.
Zhan et al., Wuhan, China. In Mol Med Report, 2014
The calcium/calmodulin-dependent protein kinase kinase 2, adenosine monophosphate-activated protein kinase (CAMKK2-AMPK) pathway mediated amyloid β42 (Aβ42)-induced synaptotoxicity and blockage of CAMKK2-protected neurons against the effect of Aβ42.
Quantitative-proteomic comparison of alpha and Beta cells to uncover novel targets for lineage reprogramming.
Wagner et al., Cambridge, United States. In Plos One, 2013
Our phosphoproteomic analysis indicated that two kinases, BRSK1 and CAMKK2, exhibit decreased phosphorylation in beta cells compared to alpha cells, and in compound-treated alpha cells compared to DMSO-treated alpha cells.
The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers through Tau phosphorylation.
Polleux et al., Los Angeles, United States. In Neuron, 2013
We show that increased intracellular calcium [Ca²⁺](i) induced by NMDA receptor activation or membrane depolarization activates AMPK in a CAMKK2-dependent manner.
ADP signaling in vascular endothelial cells: ADP-dependent activation of the endothelial isoform of nitric-oxide synthase requires the expression but not the kinase activity of AMP-activated protein kinase.
Michel et al., Boston, United States. In J Biol Chem, 2009
the expression, but not the kinase activity, of AMPK and CaMKKbeta is necessary for ADP signaling to eNOS
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