GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
Calcium/calmodulin-dependent protein kinase IV
CaMKIV, calmodulin-dependent protein kinase IV, calcium/calmodulin-dependent protein kinase IV
protein kinase that phosphorylates synapsin I; involved in neuronal calcium signaling; alternative transcript produces calspermin protein [RGD, Feb 2006] (from
NCBI)
Sponsored links
Top mentioned proteins:
CaM, CREB, CAN, V1a, CaM kinase
Papers using
CaMKIV
antibodies
Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse
Supplier
In Molecular Pain, 1993
... We do not feel that this represents a problem with the genetics background since the CaMKIV transgenic line can be considered ...
Papers on
CaMKIV
Calcium/Calmodulin-dependent protein kinase IV: A multifunctional enzyme and potential therapeutic target.
Review
New
New Delhi, India. In Prog Biophys Mol Biol, Feb 2016
UNASSIGNED: The calcium/calmodulin-dependent protein kinase IV (CAMK IV) belongs to the serine/threonine protein kinase family, and is primarily involved in transcriptional regulation in lymphocytes, neurons and male germ cells.
Caffeine and REM sleep deprivation: Effect on basal levels of signaling molecules in area CA1.
New
Houston, United States. In Mol Cell Neurosci, Feb 2016
Western blot analysis of basal protein levels of plasticity- and memory-related signaling molecules in hippocampal area CA1 showed significant down regulation of the basal levels of phosphorylated- and total-CaMKII, phosphorylated- and total-CREB as well as those of BDNF and CaMKIV in sleep deprived rats.
Structure guided design of potential inhibitors of human calcium-calmodulin dependent protein kinase IV containing pyrimidine scaffold.
New
New Delhi, India. In Bioorg Med Chem Lett, Jan 2016
UNASSIGNED: Calmodulin dependent protein kinase IV (CAMKIV) belongs to the serine/threonine protein kinase family and considered as an encouraging target for the development of novel anticancer agents.
Comparison of the Effect of Exercise on Late-Phase LTP of the Dentate Gyrus and CA1 of Alzheimer's Disease Model.
New
Houston, United States. In Mol Neurobiol, Jan 2016
Immunoblot analysis revealed no increase in the levels of phosphorylated (p)-CREB, CaMKIV, and brain-derived neurotrophic factor (BDNF) in both CA1 and DG areas of sedentary Aβ rats during L-LTP, whereas the levels of these molecules were robustly increased in exercised Aβ rats.
Lupus nephritis IgG induces the expression of calcium/calmodulin-dependent kinase type IV in podocytes and alters their function.
New
Nagasaki, Japan. In Arthritis Rheumatol, Jan 2016
T cells from patients with systemic lupus erythematosus display increased expression of calcium/calmodulin kinase IV (CaMKIV).
A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation.
New
Suzhou, China. In Autophagy, Dec 2015
In addition, we demonstrated a critical role of intracellular Ca(2+) elevation, followed by the enhanced phosphorylation of CAMK4 (calcium/calmodulin-dependent protein kinase IV) and CREB (cAMP responsive element binding protein) in the increases of FOS expression and autophagy activity.
Evolutionary and functional perspectives on signaling from neuronal surface to nucleus.
Review
New
New York City, United States. In Biochem Biophys Res Commun, May 2015
This intricate pathway depends on a specific role for multiple Ca(2+)/CaM-dependent kinases and phosphatases: α/βCaMKII phosphorylates γCaMKII to trap CaM; CaN dephosphorylates γCaMKII to dispatch it to the nucleus; and PP2A induces CaM release from γCaMKII so that CaMKK and CaMKIV can trigger CREB phosphorylation.
γCaMKII shuttles Ca²⁺/CaM to the nucleus to trigger CREB phosphorylation and gene expression.
Impact
New York City, United States. In Cell, 2014
Upon arrival within the nucleus, Ca(2+)/CaM activates CaMKK and its substrate CaMKIV, the CREB kinase.
Calcium/calmodulin-dependent protein kinase kinase 2: roles in signaling and pathophysiology.
Review
Durham, United States. In J Biol Chem, 2012
CaMKK2 is one of the most versatile of the CaMKs and will phosphorylate and activate CaMKI, CaMKIV, and AMP-activated protein kinase.
Calcium/calmodulin-dependent protein kinase IV limits organ damage in hepatic ischemia-reperfusion injury through induction of autophagy.
GeneRIF
Pittsburgh, United States. In Am J Physiol Gastrointest Liver Physiol, 2012
the protective autophagic signaling pathway serves to reduce organ damage following ischemia-reperfusion and is regulated by activation of calcium-calmodulin-dependent protein kinase type 4 signaling in hepatocytes.
Mouse models of genetic effects on cognition: relevance to schizophrenia.
Review
Genova, Italy. In Neuropharmacology, 2012
Based on functional hypotheses, gene modifications within five model systems are described: 1) dopamine (D1, D2, D3, D4, D5, DAT, COMT, MAO); 2) glutamate (GluR-A, NR1, NR2A, NR2B, GRM2, GRM3, GLAST); 3) GABA (α(5), γ(2), α(4), δGABA(A), GABA(B(1)), GAT1); 4) acetylcholine (nAChRβ2, α7, CHRM1); and 5) calcium (CaMKII-α, neurogranin, CaMKKβ, CaMKIV).
Calcium/calmodulin-dependent protein kinase IV mediates distinct features of basal and activity-dependent dendrite complexity.
GeneRIF
Augusta, United States. In Neuroscience, 2012
CaMKIV contributes to the diversity of dendrite arbors via restricted expression and regulation of distinct modes of dendrite elaboration.
Cutting edge: Calcium/Calmodulin-dependent protein kinase type IV is essential for mesangial cell proliferation and lupus nephritis.
GeneRIF
Boston, United States. In J Immunol, 2012
we demonstrated that calcium/calmodulin-dependent protein kinase type IV spontaneous and platelet-derived growth factor-stimulated mesangial cell proliferation
CaMK IV phosphorylates prohibitin 2 and regulates prohibitin 2-mediated repression of MEF2 transcription.
GeneRIF
Changchun, China. In Cell Signal, 2011
Calcium/Calmodulin-dependent kinase IV specifically binds to the C terminus of PHB2 and phosphorylates PHB2 at serine 91.
Targeting lymphocyte signaling pathways as a therapeutic approach to systemic lupus erythematosus.
Review
Boston, United States. In Curr Opin Rheumatol, 2011
Small molecules that block the kinases CaMKIV (calcium and calmodulin dependent kinase IV) and Bruton Tyrosine kinase (Btk) and the phosphatase calcineurin were shown to be effective in treating murine lupus.
NR2B-containing NMDA receptors promote neural progenitor cell proliferation through CaMKIV/CREB pathway.
GeneRIF
Xuzhou, China. In Biochem Biophys Res Commun, 2011
These results suggest that NR2B-containing NMDARs have a positive role in regulating neural progenitor cell proliferation, which may be mediated through CaMKIV phosphorylation and subsequent induction of CREB activation.
Systems biology of vaccination for seasonal influenza in humans.
Impact
Atlanta, United States. In Nat Immunol, 2011
Notably, expression of the kinase CaMKIV at day 3 was inversely correlated with later antibody titers.
Regulation of osteoclast differentiation and function by the CaMK-CREB pathway.
Impact
Tokyo, Japan. In Nat Med, 2006
Here we show that the CaMKIV-CREB pathway is crucial for osteoclast differentiation and function.
Regulation of mitochondrial biogenesis in skeletal muscle by CaMK.
Impact
GeneRIF
Dallas, United States. In Science, 2002
data suggest it mediates contractile activity-dependent gene regulation in muscle tissues and promotes mitochondrial biogenesis
An important role of neural activity-dependent CaMKIV signaling in the consolidation of long-term memory.
Impact
New Haven, United States. In Cell, 2001
Calcium/calmodulin-dependent protein kinase IV (CaMKIV) has been implicated in the regulation of CRE-dependent transcription.
