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Calcium/calmodulin-dependent protein kinase II inhibitor 2

CaMKII inhibitory protein, CaM-KIIN, hCaMKIIN, CaM-KIINbeta
This gene encodes a protein that is highly similar to the rat CaM-KII inhibitory protein, an inhibitor of calcium/calmodulin-dependent protein kinase II (CAMKII). CAMKII regulates numerous physiological functions, including neuronal synaptic plasticity through the phosphorylation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate (AMPA) receptors. Studies of the similar protein in rat suggest that this protein may function as a negative regulator of CaM-KII and may act to inhibit the phosphorylation of AMPA receptors. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CaM, CAN, ACID, Angiotensin II, V1a
Papers on CaMKII inhibitory protein
Calcium/calmodulin-dependent kinase II inhibition in smooth muscle reduces angiotensin II-induced hypertension by controlling aortic remodeling and baroreceptor function.
New
Grumbach et al., Iowa City, United States. In J Am Heart Assoc, Jun 2015
METHODS AND RESULTS: Transgenic expression of a CaMKII peptide inhibitor in VSMCs (TG SM-CaMKIIN model) reduced the blood pressure response to chronic Ang II infusion.
[Inhibiting effect of CaMKIIN up-regulation on leukemia cells growth and its mechanism].
Meng et al., Shanghai, China. In Zhonghua Xue Ye Xue Za Zhi, 2013
OBJECTIVE: To investigate the inhibitory effects of CaMKIIN on acute myeloid leukemia cell line HL-60 to explore a novel therapeutic target of leukemia.
CaMKII and stress mix it up in mitochondria.
Review
Koval et al., Iowa City, United States. In Front Pharmacol, 2013
A study using the inhibitor of CaMKII, CaMKIIN, with expression delimited to myocardial mitochondria, indicates that an underlying cause of heart disease results from the opening of the mitochondrial permeability transition pore (mPTP).
Effects of CaMKII inhibitor tatCN21 on activity-dependent redistribution of CaMKII in hippocampal neurons.
Dosemeci et al., Bethesda, United States. In Neuroscience, 2013
TatCN21 is a membrane permeable calcium/calmodulin-dependent protein kinase II (CaMKII) inhibitor derived from the inhibitor protein CaMKIIN.
Differential control of calcium homeostasis and vascular reactivity by Ca2+/calmodulin-dependent kinase II.
Grumbach et al., Iowa City, United States. In Hypertension, 2013
Using novel transgenic mice that express the inhibitor peptide CaMKIIN in smooth muscle (TG SM-CaMKIIN), we investigated the effect of CaMKII inhibition on L-type Ca(2+) channel current (ICa), cytoplasmic and sarcoplasmic reticulum Ca(2+), and vasoconstriction in mesenteric arteries.
Ca2+-independent activation of Ca2+/calmodulin-dependent protein kinase II bound to the C-terminal domain of CaV2.1 calcium channels.
Catterall et al., Seattle, United States. In J Biol Chem, 2013
Facilitation and inactivation of Ca(V)2.1 channels by binding of Ca(2+)/CaM mediates short term synaptic plasticity in transfected superior cervical ganglion neurons, and these regulatory effects are prevented by a competing peptide and the endogenous brain inhibitor CaMKIIN, which blocks binding of CaMKII to Ca(V)2.1 channels.
CaMKII determines mitochondrial stress responses in heart.
Impact
Anderson et al., Iowa City, United States. In Nature, 2012
Mitochondrial-targeted CaMKII inhibitory protein or cyclosporin A, an mPTP antagonist with clinical efficacy in ischaemia reperfusion injury, equivalently prevent mPTP opening, ΔΨm deterioration and diminish mitochondrial disruption and programmed cell death in response to ischaemia reperfusion injury.
On the mechanism of synaptic depression induced by CaMKIIN, an endogenous inhibitor of CaMKII.
Sanhueza et al., Santiago, Chile. In Plos One, 2011
To unravel CaMKIIN function and to further understand CaMKII role in synaptic strength maintenance, here we more deeply investigated the mechanism of synaptic depression induced by CN peptides (CN-depression) in rat hippocampal slices.
Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylation.
Colbran et al., Nashville, United States. In J Biol Chem, 2011
The amino acid sequence of the densin-IN domain is similar to the CaMKII inhibitor protein, CaMKIIN, and a CaMKIIN peptide competitively blocks CaMKII binding to densin.
Improving a natural CaMKII inhibitor by random and rational design.
Bayer et al., Aurora, United States. In Plos One, 2010
BACKGROUND: CaM-KIIN has evolved to inhibit stimulated and autonomous activity of the Ca(2+)/calmodulin (CaM)-dependent protein kinase II (CaMKII) efficiently, selectively, and potently (IC50 ∼100 nM).
Differential regulation of CaMKII inhibitor beta protein expression after exposure to a novel context and during contextual fear memory formation.
GeneRIF
Giese et al., London, United Kingdom. In Genes Brain Behav, 2010
We show that CaMKII N beta expression is differentially regulated by novelty and contextual fear conditioning, providing further insight into molecular basis of fear LTM.
Calmodulin kinase II is required for angiotensin II-mediated vascular smooth muscle hypertrophy.
Grumbach et al., Iowa City, United States. In Am J Physiol Heart Circ Physiol, 2010
Adenoviral transduction with the CaMKII peptide inhibitor CaMKIIN abrogated ANG II-induced VSM hypertrophy in vitro, which was augmented by overexpression of CaMKII-delta2.
Endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest and apoptosis through down-regulation of the phosphatidylinositide 3-kinase/Akt/HDM2 pathway.
GeneRIF
Cao et al., Hangzhou, China. In J Biol Chem, 2009
hCaMKIINbeta may play an important role in the regulation of tumor cell growth
A novel endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest via p27 stabilization.
Cao et al., Shanghai, China. In J Biol Chem, 2008
Here we report the characterization of a novel human endogenous CaMKII inhibitor, human CaMKII inhibitory protein alpha (hCaMKIINalpha), which directly interacts with activated CaMKII and effectively inhibits CaMKII activity.
Dual mechanism of a natural CaMKII inhibitor.
Bayer et al., Aurora, United States. In Mol Biol Cell, 2007
CaM-KIIN is a natural, specific CaMKII inhibitor protein.
Regulation of Ca2+/calmodulin kinase II inhibitor alpha (CaMKIINalpha) in virus-infected mouse brain.
Rangarajan et al., Bengaluru, India. In Biochem Biophys Res Commun, 2006
The downregulation is specific for CaMKIINalpha but not CaMKIINbeta mRNA.
Characterization of a calmodulin kinase II inhibitor protein in brain.
GeneRIF
Soderling et al., Portland, United States. In Proc Natl Acad Sci U S A, 1998
Functional study of the rat homolog
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