CaMKII inhibitory protein
CaMKII and stress mix it up in mitochondria.
Iowa City, United States. In Front Pharmacol, 2013
A study using the inhibitor of CaMKII, CaMKIIN, with expression delimited to myocardial mitochondria, indicates that an underlying cause of heart disease results from the opening of the mitochondrial permeability transition pore (mPTP).
CaMKII determines mitochondrial stress responses in heart.
Iowa City, United States. In Nature, 2012
Mitochondrial-targeted CaMKII inhibitory protein or cyclosporin A, an mPTP antagonist with clinical efficacy in ischaemia reperfusion injury, equivalently prevent mPTP opening, ΔΨm deterioration and diminish mitochondrial disruption and programmed cell death in response to ischaemia reperfusion injury.