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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Calumenin

Calu, RCA1
The product of this gene is a calcium-binding protein localized in the endoplasmic reticulum (ER) and it is involved in such ER functions as protein folding and sorting. This protein belongs to a family of multiple EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008] (from NCBI)
Top mentioned proteins: CAN, Cystic Fibrosis Transmembrane Conductance Regulator, V1a, ACID, HAD
Papers using Calu antibodies
Pre-processing Agilent microarray data
Supplier
Ciardiello F et al., In British Journal of Cancer, 2006
... The human NSCLC CALU-3 cell line was provided by the American Type Culture Collection (Manassas, VA, USA) and maintained in RPMI 1640 supplemented with 10% fetal bovine serum (FBS; Life Technologies, Gaithersburg, MD, USA) in ...
Papers on Calu
Phloretin exhibits an anticancer effect and enhances the anticancer ability of cisplatin on non-small cell lung cancer cell lines by regulating expression of apoptotic pathways and matrix metalloproteinases.
New
Jin et al., Xi'an, China. In Int J Oncol, Feb 2016
It was evaluated and confirmed, in the present study, that phloretin inhibited proliferation and induced apoptosis in A549, Calu-1, H838 and H520 cells in a dose-dependent manner, phloretin also suppressed the invasion and migration of NSCLC cells.
Cannabinoid receptor-2 agonist inhibits macrophage induced EMT in non-small cell lung cancer by downregulation of EGFR pathway.
New
Ganju et al., Columbus, United States. In Mol Carcinog, Feb 2016
JWH-015 inhibited EMT in NSCLC cells A549 and also reversed the mesenchymal nature of CALU-1 cells by downregulation of EGFR signaling targets like ERK and STAT3.
Ciprofloxacin-Loaded Inorganic-Organic Composite Microparticles To Treat Bacterial Lung Infection.
New
Healy et al., Poitiers, France. In Mol Pharm, Feb 2016
Transport studies of CIP across Calu-3 cell monolayers, in the presence of various calcium concentrations, showed a decrease of up to 84% in CIP apparent permeability.
Thyroid hormone (levothyroxine) replacement via the respiratory route by inhalation: in vitro exploratory studies.
New
Imran et al., Halifax, Canada. In Expert Opin Drug Deliv, Jan 2016
Calu-3 cell line was used for permeation studies.
Mechanosensitivity of wild-type and G551D cystic fibrosis transmembrane conductance regulator (CFTR) controls regulatory volume decrease in simple epithelia.
New
Huang et al., Hong Kong, Hong Kong. In Faseb J, Jan 2016
Hypotonicity activated CFTR single channels in cell-attached membrane patches and WT-CFTR-mediated short-circuit current (Isc) in Calu-3 cells, and this was independent of Ca(2+) and cAMP/PKA signaling.
Metformin increases antitumor activity of MEK inhibitors through GLI1 downregulation in LKB1 positive human NSCLC cancer cells.
New
Morgillo et al., Napoli, Italy. In Oncotarget, Jan 2016
RESULTS: The combination of metformin with MEK-I showed a strong anti-proliferative and proapoptotic effect in Calu-3, H1299, H358 and H1975 human NSCLC cell lines, independently from the KRAS mutational status.
Human cathelicidin, LL-37, inhibits respiratory syncytial virus infection in polarized airway epithelial cells.
New
Haynes et al., Atlanta, United States. In Bmc Res Notes, Dec 2015
An air-liquid interface (ALI) Calu-3 model that more closely mimics the human airway epithelium was established.
Pharmaceutical applications of the Calu-3 lung epithelia cell line.
Review
Young et al., Australia. In Expert Opin Drug Deliv, 2013
INTRODUCTION: The Calu-3 lung cell line has been shown to be a promising in vitro model of airway epithelia due to its similarity to in vivo physiology.
Control of sleep by cyclin A and its regulator.
Impact
GeneRIF
Young et al., New York City, United States. In Science, 2012
findings show that cyclin A (CycA) and regulator of cyclin A1, essential cell cycle factors, function in postmitotic neurons to promote sleep
Copy number variation and warfarin dosing: evaluation of CYP2C9, VKORC1, CYP4F2, GGCX and CALU.
GeneRIF
Desnick et al., New York City, United States. In Pharmacogenomics, 2012
Quantitative PCR assays for VKORC1, CYP4F2, GGCX and CALU identified two copies in all populations.
Spatio-temporal expression analysis of the calcium-binding protein calumenin in the rodent brain.
GeneRIF
Sieghart et al., Vienna, Austria. In Neuroscience, 2012
This study points to a possible important role of calumenin in migration and differentiation of neurons
The bZIP transcription factor Rca1p is a central regulator of a novel CO₂ sensing pathway in yeast.
GeneRIF
Mühlschlegel et al., Canterbury, United Kingdom. In Plos Pathog, 2012
Rca1p appears to regulate cellular metabolism in response to CO(2) availability in environments as diverse as the phagosome, yeast communities or liquid culture.
The intracellular transport and secretion of calumenin-1/2 in living cells.
GeneRIF
Teng et al., Beijing, China. In Plos One, 2011
Study found the secretion of calu-1/2-EGFP required microtubule integrity, and that calu-1/2-EGFP-containing vesicles were transported by the motor proteins Kif5b and cytoplasmic dynein.
Mechanisms of bicarbonate secretion: lessons from the airways.
Review
Bridges, North Chicago, United States. In Cold Spring Harb Perspect Med, 2011
Studies with Calu-3 cells, an airway serous model with high expression of CFTR, also show the secretion of HCO(3)(-) when cells are stimulated with cAMP-mediated agonists.
Anion secretion by a model epithelium: more lessons from Calu-3.
Review
Hanrahan et al., Montréal, Canada. In Acta Physiol (oxf), 2011
The Calu-3 human lung adenocarcinoma cell line has become a popular model for studying airway secretion because it can be cultured as a flat sheet, expresses the cystic fibrosis transmembrane conductance regulator and several acinar cell markers, forms polarized monolayers with tight junctions, has robust cAMP-stimulated anion transport, and responds to secretagogues that regulate the glands in vivo.
Mechanosensitive gating of CFTR.
Impact
Huang et al., Hong Kong, Hong Kong. In Nat Cell Biol, 2010
CFTR stretch-mediated activation resulted in chloride transport in Calu-3 human airway epithelial cells and mouse intestinal tissues.
The rapidly expanding CREC protein family: members, localization, function, and role in disease.
Review
Honoré, Århus, Denmark. In Bioessays, 2009
The CREC family of low affinity, Ca2+-binding, multiple EF-hand proteins are encoded by five genes, RCN1, RCN2, RCN3, SDF4, and CALU, resulting in reticulocalbin, ER Ca2+-binding protein of 55 kDa (ERC-55), reticulocalbin-3, Ca2+-binding protein of 45 kDa (Cab45), and calumenin.
Connexins induce and maintain tight junctions in epithelial cells.
Review
Sawada et al., Sapporo, Japan. In J Membr Biol, 2007
We introduced the human Cx26 gene into the human airway epithelial cell line Calu-3 and used a model of tight junction disruption by the Na(+)/K(+)-ATPase inhibitor ouabain.
Spastic paraplegia and OXPHOS impairment caused by mutations in paraplegin, a nuclear-encoded mitochondrial metalloprotease.
Impact
Ballabio et al., Milano, Italy. In Cell, 1998
Paraplegin is highly homologous to the yeast mitochondrial ATPases, AFG3, RCA1, and YME1, which have both proteolytic and chaperon-like activities at the inner mitochondrial membrane.
Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1.
Impact
Wigler et al., In Nature, 1983
The homologue of the viral Kirsten ras (v-Ki-ras) gene found in the human lung carcinoma cell line, Calu-1, has an intron-exon structure similar to that of the human homologue of the viral Harvey ras (v-Ha-ras) gene.
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