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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.


Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Calnexin, HAD, fibrillin-1, V1a
Papers using calreticulin antibodies
Regulated motion of glycoproteins revealed by direct visualization of a single cargo in the endoplasmic reticulum
Wada Ikuo et al., In The Journal of Cell Biology, 2005
... The vector pEYFP-ER expresses the YFP variant protein YE, which contains an N-terminal cleavable calreticulin signal sequence and a C-terminal KDEL ER retention signal and was purchased from Clontech Laboratories, Inc ...
Surfactant protein C biosynthesis and its emerging role in conformational lung disease
Roemer Klaus, In PLoS ONE, 2004
... Anti-V5 mouse mAb (R960-25) was obtained from Invitrogen, anti-calreticulin (H-170) from Santa Cruz Biotechnology (Santa Cruz, CA); and ...
Calreticulin: one protein, one gene, many functions
Mangge Harald et al., In Biologics : Targets & Therapy, 1998
... LifeSpan Biosciences, Seattle, WA; goat antimouse antibodies, Santa Cruz, CA), as well as a sheep antimouse calreticulin antibody (Abcam, Cambridge, UK) ...
Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1
Hetzer Martin W. et al., In The Journal of Cell Biology, 1995
... [Invitrogen] and rabbit [Novus Biologicals]), BAF (Novus Biologicals), Sun1 (Abcam), tubulin (Sigma-Aldrich), LBR (Abcam), and calreticulin (Novus Biologicals) are commercially available ...
Papers on calreticulin
Identification of the murine H-2D(b) and human HLA-A*0201 MHC class I-restricted HPV6 E7-specific cytotoxic T lymphocyte epitopes.
Pai et al., Baltimore, United States. In Cancer Immunol Immunother, Feb 2016
In order to enhance the host immune responses against the HPV E7 antigen, we linked calreticulin (CRT) to HPV-6b E7 and found that vaccinating C57BL/6 mice with the HPV-6b CRT/E7 DNA vaccine is able to induce a CD8(+) T cell response that recognizes an H-2D(b)-restricted E7aa21-29 epitope.
Thrombocytosis and STAT5 activation in chronic myelogenous leukaemia are not associated with JAK2 V617F or calreticulin mutations.
Theil et al., Cleveland, United States. In J Clin Pathol, Feb 2016
AIMS: Marked thrombocytosis is uncommon in chronic myelogenous leukaemia (CML) but may be associated with mutation of JAK2 V617F, calreticulin (CALR) and/or phospho-STAT5 (p-STAT5) activation in other myeloproliferative neoplasms (MPNs), particularly essential thrombocythaemia (ET).
Comparative proteomic analysis of Litopenaeus vannamei gills after vaccination with two WSSV structural proteins.
Tsai et al., Kao-hsiung, Taiwan. In Fish Shellfish Immunol, Feb 2016
The list of up-regulated protein spots found exclusively in rVP28-vaccinated shrimp include calreticulin and heat shock protein 70 with chaperone properties, ubiquitin, and others.
N-glycan based ER molecular chaperone and protein quality control system: the calnexin binding cycle.
Hebert et al., Amherst Center, United States. In Traffic, Jan 2016
UNASSIGNED: Helenius and colleagues proposed over twenty-years ago a paradigm-shifting model for how chaperone binding in the endoplasmic reticulum was mediated and controlled for a new type of molecular chaperone- the carbohydrate binding chaperones, calnexin and calreticulin.
Isolation and Characterization of Pepper Genes Interacting with the CMV-P1 Helicase Domain.
Kang et al., Seoul, South Korea. In Plos One, Dec 2015
Silencing formate dehydrogenase and calreticulin-3 precursor led to reduced virus accumulation.
Proteomics-Based Identification and Analysis of Proteins Associated with Helicobacter pylori in Gastric Cancer.
Guan et al., Guiyang, China. In Plos One, Dec 2015
We detected 135 differently expressed proteins from the three cell lines using proteome technology, and 10 differential proteins common to the three cell lines were selected and identified by LC-MS/MS as well as verified by western blot: β-actin, L-lactate dehydrogenase (LDH), dihydrolipoamide dehydrogenase (DLD), pre-mRNA-processing factor 19 homolog (PRPF19), ATP synthase, calmodulin (CaM), p64 CLCP, Ran-specific GTPase-activating protein (RanGAP), P43 and calreticulin.
Myeloproliferative neoplasms: Current molecular biology and genetics.
Saeidi, Kermān, Iran. In Crit Rev Oncol Hematol, Dec 2015
Somatic mutations in an endoplasmic reticulum chaperone, named calreticulin (CALR), is the second most common mutation in patients with ET and PMF after JAK2 V617F mutation.
[Relationship between Calreticulin Gene Mutation and JAK2/MPL Negative Myeloproliferative Neoplasms].
Wei et al., Taiyuan, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, Oct 2015
In 2013 two research teams demonstrated that whole genome sequencing technology (WGS) was used to detect calreticulin gene mutation in essential thrombocythaemia (ET) and primary myelofibrosis (PMF) patients with JAK2V617F⁻ and MPL⁻ mutations.
Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding.
Kwon et al., South Korea. In Nat Cell Biol, Jul 2015
N-terminal arginylation of BiP (also known as GRP78), protein disulphide isomerase and calreticulin is co-induced with autophagy during innate immune responses to cytosolic foreign DNA or proteasomal inhibition, associated with increased ubiquitylation.
[The Concept of Immunogenic Cell Death in Antitumor Immunity].
Špíšek et al., In Klin Onkol, 2014
The immunogenic characteristics of immunogenic cell death are mainly mediated by damage-associated molecular patterns represented by preapoptotic exposure of calreticulin and heat shock proteins (HSP70 and HSP90) from endoplasmic reticulum at the cell surface and active secretion of adenosintriphospate.
Association between Genetic Variants and Diabetes Mellitus in Iranian Populations: A Systematic Review of Observational Studies.
Amoli et al., Tehrān, Iran. In J Diabetes Res, 2014
We found significant association between CTLA-4, IL-18, VDR, TAP2, IL-12, and CD4 genes and T1DM, HNFα and MODY, haptoglobin, paraoxonase, leptin, TCF7L2, calreticulin, ERα, PPAR-γ2, CXCL5, calpain-10, IRS-1 and 2, GSTM1, KCNJ11, eNOS, VDR, INSR, ACE, apoA-I, apo E, adiponectin, PTPN1, CETP, AT1R, resistin, MMP-3, BChE K, AT2R, SUMO4, IL-10, VEGF, MTHFR, and GSTM1 with T2DM or its complications.
Somatic mutations of calreticulin in myeloproliferative neoplasms.
Kralovics et al., Pavia, Italy. In N Engl J Med, 2014
Resequencing of CALR, encoding calreticulin, was then performed in cohorts of patients with myeloid neoplasms.
Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2.
Green et al., Aş Şanamayn, Syria. In N Engl J Med, 2014
The mutation status of the gene encoding calreticulin (CALR) was assessed in an additional 1345 hematologic cancers, 1517 other cancers, and 550 controls.
Immunogenic cell death and DAMPs in cancer therapy.
Vandenabeele et al., Gent, Belgium. In Nat Rev Cancer, 2012
The immunogenic characteristics of ICD are mainly mediated by damage-associated molecular patterns (DAMPs), which include surface-exposed calreticulin (CRT), secreted ATP and released high mobility group protein B1 (HMGB1).
An immunosurveillance mechanism controls cancer cell ploidy.
Kroemer et al., Villejuif, France. In Science, 2012
We report that hyperploid cancer cells become immunogenic because of a constitutive endoplasmic reticulum stress response resulting in the aberrant cell surface exposure of calreticulin.
Proteinase 3, the autoantigen in granulomatosis with polyangiitis, associates with calreticulin on apoptotic neutrophils, impairs macrophage phagocytosis, and promotes inflammation.
Witko-Sarsat et al., Paris, France. In J Immunol, 2012
Proteinase 3 externalized at the membrane of apoptotic neutrophils can bind and possibly interfere with CRT function, thus impairing phagocytosis of apoptotic neutrophils and promoting inflammation.
Umbilical cord blood levels of maternal antibodies reactive with p200 and full-length Ro 52 in the assessment of risk for cardiac manifestations of neonatal lupus.
Buyon et al., New York City, United States. In Arthritis Care Res (hoboken), 2012
Maternal reactivity to p200 does not confer an added risk to fetal conduction defects over full-length Ro 52 or Ro 60 autoantibodies.
Hepatitis B virus-induced calreticulin protein is involved in IFN resistance.
Zhu et al., Wuhan, China. In J Immunol, 2012
CRT enhances hepatitis B virus replication by suppressing endogenous interferon (IFN)-alpha production and inhibiting the downstream antiviral effectors of IFN-alpha.
Arginylated calreticulin at plasma membrane increases susceptibility of cells to apoptosis.
Hallak et al., Córdoba, Argentina. In J Biol Chem, 2012
post-translational arginylation of CRT can regulate its intracellular localization, cell function, and survival
Novel evidence of the involvement of calreticulin in major psychiatric disorders.
Darvish et al., Tehrān, Iran. In Prog Neuropsychopharmacol Biol Psychiatry, 2012
we introduce a novel mutation in a case of substance-induced psychosis in the first intron of CALR.
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