Calpain restrains the stem cells compartment in breast cancer.
Trieste, Italy. In Cell Cycle, Feb 2016
Calpain modulates by proteolytic cleavage many cellular substrates and its activity is often deregulated in cancer cells, therefore calpain inhibition has been proposed as a therapeutical strategy for a number of malignancies.
Calpains and Coronary Vascular Disease.
Warren, United States. In Circ J, Jan 2016
Uncontrolled activation of calpain has been found to be involved in the pathogenesis of myocardial reperfusion injury, cardiac hypertrophy, myocardial stunning and cardiac ischemia.
The calpain system and cancer.
Nottingham, United Kingdom. In Nat Rev Cancer, 2011
Calpain activity is implicated in several fundamental physiological processes, including cytoskeletal remodelling, cellular signalling, apoptosis and cell survival.