Calpain restrains the stem cells compartment in breast cancer.
Trieste, Italy. In Cell Cycle, Feb 2016
Calpain modulates by proteolytic cleavage many cellular substrates and its activity is often deregulated in cancer cells, therefore calpain inhibition has been proposed as a therapeutical strategy for a number of malignancies.
Calpain dysregulation in Alzheimer's disease.
Chicago, United States. In Isrn Biochem, 2011
Alzheimer's disease (AD) is characterized by the presence of senile plaques and neurofibrillary tangles in the neocortex and hippocampus of AD patients.
The calpain system and cancer.
Nottingham, United Kingdom. In Nat Rev Cancer, 2011
Calpain activity is implicated in several fundamental physiological processes, including cytoskeletal remodelling, cellular signalling, apoptosis and cell survival.