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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.


Calpain, Calpain A, CalpA, EST C
Top mentioned proteins: PrP, calpastatin, CAN, calpain 2, V1a
Papers using Calpain antibodies
Synergistic apoptosis induction in leukemic cells by the phosphatase inhibitor salubrinal and proteasome inhibitors.
Hofmann Thomas G., In PLoS ONE, 2008
... CA, USA); Anti-ATF6 antibody was from Millipore (Billerica, MA, USA) and antibodies against phospho-IRE1, Calpain-1, Calpain-2 were from Abcam (Cambridge, MA, USA) ...
Platelet sarcoplasmic endoplasmic reticulum Ca2+-ATPase and mu-calpain activity are altered in type 2 diabetes mellitus and restored by rosiglitazone
Zou Ming-Hui et al., In Journal of Cellular and Molecular Medicine, 2007
... Calpain 1 antibody, calpain 1-specific siRNA and scrambled siRNA were purchased from Santa Cruz Biotechnology, Inc ...
Papers on Calpain
Retinoids and glucocorticoids have opposite effects on actin cytoskeleton rearrangement in hippocampal HT22 cells.
Jean-Benoît et al., Bordeaux, France. In Int J Biochem Cell Biol, Feb 2016
Calpain activity on spectrin was increased by retinoic acid and decreased by dexamethasone (26±14% and -57±5%); retinoic acid mildly but significantly modified the effect of dexamethasone (-44±7%).
E-Cadherin fragments as potential mediators for peritoneal metastasis in advanced epithelial ovarian cancer.
Mahner et al., Hamburg, Germany. In Br J Cancer, Feb 2016
METHODS: Tumour tissue of 105 advanced EOC patients was evaluated for protein expression of E-Cad, β-Catenin and Calpain by western blotting and immunohistochemistry. Expression patterns were compared between tumours with solely intraperitoneal (pT3c, pN0; n=41) and tumours with retroperitoneal metastases (pT1a-3c, pN1; n=64).
Targeting host calpain proteases decreases influenza A virus infection.
Si-Tahar et al., Hong Kong, Hong Kong. In Am J Physiol Lung Cell Mol Physiol, Feb 2016
Calpain expression and activity were found altered in IAV-infected bronchial epithelial cells.
Calpain restrains the stem cells compartment in breast cancer.
Demarchi et al., Trieste, Italy. In Cell Cycle, Feb 2016
Calpain modulates by proteolytic cleavage many cellular substrates and its activity is often deregulated in cancer cells, therefore calpain inhibition has been proposed as a therapeutical strategy for a number of malignancies.
Excess Nitric Oxide Activates TRPV1-Ca(2+)-Calpain Signaling and Promotes PEST-dependent Degradation of Liver X Receptor α.
Lee et al., Taipei, Taiwan. In Int J Biol Sci, Dec 2015
In addition, SNAP induced calcium (Ca(2+)) influx into cells, increased calpain activity and promoted the formation of calpain-LXRα complex.
Heart mitochondria and calpain 1: Location, function, and targets.
Lesnefsky et al., Richmond, United States. In Biochim Biophys Acta, Nov 2015
Calpain 1 is an ubiquitous Ca(2+)-dependent cysteine protease.
Calpain in Breast Cancer: Role in Disease Progression and Treatment Response.
Martin et al., Nottingham, United Kingdom. In Pathobiology, Sep 2015
The ubiquitously expressed micro (µ)-calpain and milli (m)-calpain are archetypal family members that require calcium for function and can be inhibited by their endogenous inhibitor calpastatin.
Role of the calpain on the development of diabetes mellitus and its chronic complications.
Su et al., Harbin, China. In Biomed Pharmacother, Aug 2015
Calpain is a ubiquitous calcium-sensitive protease that is essential for normal physiologic function.
CalpB modulates border cell migration in Drosophila egg chambers.
Ádám et al., Debrecen, Hungary. In Bmc Dev Biol, 2011
Study demonstrates that CalpB but not the structurally related CalpA has an important modulator function during in vivo cell migration.
Calpain dysregulation in Alzheimer's disease.
Ferreira, Chicago, United States. In Isrn Biochem, 2011
Alzheimer's disease (AD) is characterized by the presence of senile plaques and neurofibrillary tangles in the neocortex and hippocampus of AD patients.
The calpain system and cancer.
Martin et al., Nottingham, United Kingdom. In Nat Rev Cancer, 2011
Calpain activity is implicated in several fundamental physiological processes, including cytoskeletal remodelling, cellular signalling, apoptosis and cell survival.
Implicating calpain in tau-mediated toxicity in vivo.
Steinhilb et al., Mount Pleasant, United States. In Plos One, 2010
Data show that mutations that disrupted endogenous calpainA or calpainB activity in transgenic flies suppressed tau toxicity.
The Ca2+-dependent protease Calpain A regulates Cactus/I kappaB levels during Drosophila development in response to maternal Dpp signals.
Araujo et al., Rio de Janeiro, Brazil. In Mech Dev, 2009
Dpp signals increase Cactus levels through Calpain A inhibition, thereby interfering with Dorsal activation
Talin phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitylation and cell migration.
Ginsberg et al., Chapel Hill, United States. In Nat Cell Biol, 2009
Calpain-mediated cleavage of talin has a key role in focal adhesion turnover; however, the talin head domain, one of the two cleavage products, stimulates integrin activation, localizes to focal adhesions and maintains cell edge protrusions, suggesting that other steps, downstream of talin proteolysis, are required for focal adhesion disassembly.
Concerted multi-pronged attack by calpastatin to occlude the catalytic cleft of heterodimeric calpains.
Green et al., Memphis, United States. In Nature, 2008
Their endogenous inhibitor, calpastatin, consists of four inhibitory repeats, each of which neutralizes an activated calpain with exquisite specificity and potency.
Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis.
Simon et al., Bern, Switzerland. In Nat Cell Biol, 2006
Apoptosis was associated with calpain-mediated Atg5 cleavage, resulting in an amino-terminal cleavage product with a relative molecular mass of 24,000 (Mr 24K).
Calpain-mediated proteolysis of talin regulates adhesion dynamics.
Huttenlocher et al., Madison, United States. In Nat Cell Biol, 2004
Here, we show that proteolysis of talin by the intracellular calcium-dependent protease calpain is critical for focal adhesion disassembly.
Potential Use of Calpain Inhibitors as Brain Injury Therapy
Anagli et al., Boca Raton, United States. In Unknown Journal, 0001
One of the well understood molecular mechanism of TBI is the hyperactivation of the calpain enzyme.
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