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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Calpain 6

calpain 6
human and mouse homologs lack the calmodulin-like domain present in other members of the calpain family of calcium-dependent, cysteine proteases and may be proteolytically inactive [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Calpain, CAN, doublecortin, Oct-1, Arylamine N-Acetyltransferase
Papers on calpain 6
Transcriptional sexual dimorphism in elongating bovine embryos: implications for XCI and sex determination genes.
Gutierrez-Adan et al., Madrid, Spain. In Reproduction, 2011
To determine the timing of XCI, we analyzed in day 14 bovine embryos the sexual dimorphic transcription of seven X-linked genes known to be upregulated in female blastocysts (X24112, brain-expressed X-linked 2 (BEX2), ubiquitin-conjugating enzyme E2A (UBE2A), glucose-6-phosphate dehydrogenase (G6PD), brain-expressed X-linked 1 (BEX1), calpain 6 (CAPN6), and spermidine/spermine N-acetyltransferase 1 (SAT1)).
The PI3K-Akt pathway regulates calpain 6 expression, proliferation, and apoptosis.
Zha et al., Shanghai, China. In Cell Signal, 2011
Calpain 6 (CAPN6), one member of the family, is unique in that it lacks the active-site cysteine residues for protease activity.
Calpain 6 supports tumorigenesis by inhibiting apoptosis and facilitating angiogenesis.
Chun et al., South Korea. In Cancer Lett, 2008
Since calpain 6 is overexpressed in uterine cervical cancer tissue compared to normal tissue, we sought to define the role of calpain 6 during tumorigenesis.
Increased expression of calpain 6 during the progression of uterine cervical neoplasia: immunohistochemical analysis.
Lee et al., Seoul, South Korea. In Oncol Rep, 2008
Calpain 6 (Capn6) is one of the calcium-dependent intracellular nonlysosomal proteases and is known for tissue-specific expression, primarily in the placenta.
Calpain 6 is involved in microtubule stabilization and cytoskeletal organization.
Kurihara et al., Tokyo, Japan. In Mol Cell Biol, 2007
In this family, calpain 6 (Capn6) is unique in that it lacks the active-site cysteine residues requisite for protease activity.
Increased expression of calpain 6 in uterine sarcomas and carcinosarcomas: an immunohistochemical analysis.
Lee et al., Seoul, South Korea. In Int J Gynecol Cancer, 2007
Calpain 6 (Capn6) is one of the calcium-dependent intracellular nonlysosomal proteases.
Down-regulation of calpain 9 is linked to hypertensive heart and kidney disease.
Wohlfart et al., Frankfurt am Main, Germany. In Cell Physiol Biochem, 2004
Using real-time PCR, we found calpain 6 and 9 down-regulated by more than 50% and the endogenous calpain inhibitor calpastatin up-regulated by 225%, respectively, in the hearts of Dahl salt-sensitive rats on a high salt (4% NaCl) compared to normal salt diet.
Differential gene expression in leiomyosarcoma.
Skubitz et al., Minneapolis, United States. In Cancer, 2003
RESULTS: A number of genes were found to be differentially expressed in these sample sets, and six genes including cyclin-dependent kinase inhibitor 2A, diaphanous (Drosophila homolog) 3, doublecortin, calpain 6, interleukin-17B, and proteolipid 1 were found to be overexpressed in LMS compared with normal myometrium and 18 other tissues.
Differential gene expression in uterine leiomyoma.
Skubitz et al., Minneapolis, United States. In J Lab Clin Med, 2003
Four genes--doublecortin, calpain 6, interleukin-17B, and proteolipid protein 1--were found to be overexpressed in leiomyomas compared with normal myometrium and eighteen other tissues.
Slug is a novel downstream target of MyoD. Temporal profiling in muscle regeneration.
Hoffman et al., Washington, D.C., United States. In J Biol Chem, 2002
Potential downstream targets of MyoD were identified by temporal expression, promoter data base mining, and gel shift assays; Slug and calpain 6 were identified as novel MyoD targets.
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