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Kv channel interacting protein 4

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Kv1.4, CAN, Kv4.2, KChIP1, SM22alpha
Papers using CALP antibodies
Recurrent breakpoints at 9q31 and 22q12.2 in extraskeletal myxoid chondrsarcoma
Mentzel Thomas et al., In Virchows Archiv, 1987
... CALP1:400DAKO, Glostrup, Denmark ...
Papers on CALP
Identification of lung cancer histology-specific variants applying Bayesian framework variant prioritization approaches within the TRICL and ILCCO consortia.
Hung et al., Calgary, Canada. In Carcinogenesis, Nov 2015
Three novel loci in the suggestive range were identified based on our Bayesian framework analyses: KCNIP4 at 4p15.2 (rs6448050, P = 4.6×10(-7)) and MTMR2 at 11q21 (rs10501831, P = 3.1×10(-6)) with SCC, as well as GAREM at 18q12.1 (rs11662168, P = 3.4×10(-7)) with AC.
A genome-wide association study identifies variants in KCNIP4 associated with ACE inhibitor-induced cough.
Roden et al., Nashville, United States. In Pharmacogenomics J, Aug 2015
A GWAS (1595 cases and 5485 controls) identified associations on chromosome 4 in an intron of KCNIP4.
Different KChIPs compete for heteromultimeric assembly with pore-forming Kv4 subunits.
Wang et al., Beijing, China. In Biophys J, Jul 2015
Further analysis of channel gating kinetics from different Kv4-KChIP4 subunit compositions confirms that both KChIP4a and KChIP4bl can modulate the channel complex function upon coassembly.
Informed genome-wide association analysis with family history as a secondary phenotype identifies novel loci of lung cancer.
Hung et al., Toronto, Canada. In Genet Epidemiol, Mar 2015
When combining the two stages of the study, the strongest association was found in rs1158970 at Ch4p15.2 encoding KCNIP4 with an OR of 0.89 (95% CI=0.85, 0.94, P=9.64×10(-6)).
A genome-wide association study of growth trait-related single nucleotide polymorphisms in Chinese Yancheng chickens.
Chen et al., Yancheng, China. In Genet Mol Res, 2014
Four genes (FAM184B, KCNIP4, MIR15A, and GLI3) were closely associated with body weight.
Structural differences among subfamilies of EF-hand proteins--a view from the pseudo two-fold symmetry axis.
Kretsinger et al., Yokohama, Japan. In Proteins, 2014
We describe and compare values of dE(ø) and of δdF(ø) for EF-hand proteins of five subfamilies--CTER, CPV, S100, PARV, CALP--in calci- and apo- forms, with and without bound target proteins.
The novel Aryl hydrocarbon receptor inhibitor biseugenol inhibits gastric tumor growth and peritoneal dissemination.
Sheu et al., T'ai-chung-shih, Taiwan. In Oncotarget, 2014
Moreover, Biseugenol enhanced Calpain-10 (Calp-10) and AhR interaction results in Snail downregulation.
The tetramerization domain potentiates Kv4 channel function by suppressing closed-state inactivation.
Wang et al., Beijing, China. In Biophys J, 2014
We recently showed that the auxiliary KChIP4a subunit contains an N-terminal Kv4 inhibitory domain (KID) that directly interacts with Kv4.3 channels to enhance CSI.
The dog as a natural animal model for study of the mammary myoepithelial basal cell lineage and its role in mammary carcinogenesis.
Zappulli et al., Philadelphia, United States. In J Comp Pathol, 2014
Single and double immunohistochemistry was performed on serial sections of 10 normal canine mammary glands and 65 CMCs to evaluate expression of cytokeratin (CK) 8/18, CK5, CK14, α-smooth muscle actin (SMA), calponin (CALP), p63 and vimentin (VIM).
The stoichiometry and biophysical properties of the Kv4 potassium channel complex with K+ channel-interacting protein (KChIP) subunits are variable, depending on the relative expression level.
Nakajo et al., Hayama, Japan. In J Biol Chem, 2014
In this study, we expressed Kv4.2 and KChIP4 with various ratios in Xenopus oocytes and observed that the biophysical properties of Kv4.2 gradually changed with the increase in co-expressed KChIP4.
Axonal guidance signaling pathway interacting with smoking in modifying the risk of pancreatic cancer: a gene- and pathway-based interaction analysis of GWAS data.
Li et al., Houston, United States. In Carcinogenesis, 2014
Five intergenic region SNPs and two SNPs of the EVC and KCNIP4 genes had P interaction < 0.00003.
Interactions of KChIP4a and its mutants with Ca2+ or Kv4.3 N-terminus by affinity capillary electrophoresis.
Wang et al., Beijing, China. In Anal Biochem, 2014
Thus, affinity capillary electrophoresis (ACE) was employed to quantitatively evaluate the interactions between KChIPs and Kv4.3 N terminus (KvN) and between KChIP4a/related mutants and Ca(2+) for the first time.
Ischemia and reperfusion induce differential expression of calpastatin and its homologue high molecular weight calmodulin-binding protein in murine cardiomyocytes.
Sharma et al., Saskatoon, Canada. In Plos One, 2013
In the heart, calpastatin (Calp) and its homologue high molecular weight calmodulin-binding protein (HMWCaMBP) regulate calpains (Calpn) by inhibition.
Suicidal ideation during antidepressant treatment: do genetic predictors exist?
Perroud, Genève, Switzerland. In Cns Drugs, 2011
In this perspective, several genetic predictors have been highlighted, the majority of which relate to common mechanisms of antidepressant action: genes involved in the neurotrophic and synaptic plasticity systems (CREB1, and BDNF and its receptor NTRK2), noradrenergic system (ADRA2A), glutamatergic system (GRIA3, GRIK2 and GDA), inflammatory and hypothalamic-pituitary-adrenal (HPA) axis systems (IL28RA and FKBP5) and in other brain functions (PAPLN, APOO, KCNIP4 and ELP3).
RNA polymerase III drives alternative splicing of the potassium channel-interacting protein contributing to brain complexity and neurodegeneration.
Pagano et al., Genova, Italy. In J Cell Biol, 2011
The synthesis of the variant KCNIP4 isoform is also detrimental to brain physiology, as it results in the concomitant blockade of the fast kinetics of potassium channels.
Functional rescue of Kv4.3 channel tetramerization mutants by KChIP4a.
Wang et al., Beijing, China. In Biophys J, 2010
KChIP4a functions to promote tetrameric assembly and enhance surface expression of Kv4 channels.
KChIP4a regulates Kv4.2 channel trafficking through PKA phosphorylation.
Hoffman et al., Bethesda, United States. In Mol Cell Neurosci, 2010
These data demonstrate that PKA phosphorylation of Kv4.2 plays an important role in the trafficking of Kv4.2 through its specific interaction with KChIP4a.
Structural Insights into KChIP4a Modulation of Kv4.3 Inactivation.
Wang et al., Beijing, China. In J Biol Chem, 2009
N-terminal binding of Kv4.3 to the core of KChIP4a mobilizes the KChIP4a N terminus, which serves as the slow inactivation gate.
Multiple Kv channel-interacting proteins contain an N-terminal transmembrane domain that regulates Kv4 channel trafficking and gating.
Pfaffinger et al., Houston, United States. In J Biol Chem, 2009
KChIP4a, KChIP2x, and KChIP3x comprise a novel class of KChIP isoforms characterized by an unusual transmembrane domain at their N termini that modulates Kv4 channel gating and trafficking.
A role for calsenilin and related proteins in multiple aspects of neuronal function.
Buxbaum, New York City, United States. In Biochem Biophys Res Commun, 2004
For example, KChIP1, KChIP2, and CALP can all bind presenilins and can all modulate A-type potassium channels.
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