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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 23 Nov 2014.

Calnexin

Calnexin, GPAT
This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, STEP, Insulin, CAN, HAD
Papers using Calnexin antibodies
The matrix protein of Marburg virus is transported to the plasma membrane along cellular membranes: exploiting the retrograde late endosomal pathway.
Supplier
Pekosz Andrew, In PLoS Pathogens, 2003
... Rabbit antiserum against Calnexin (Sigma Aldrich, France), mouse anti-ADRP (clone ...
Egr1 is activated by 17beta-estradiol in MCF-7 cells by mitogen-activated protein kinase-dependent phosphorylation of ELK-1
Supplier
Andre Frederic, In PLoS ONE, 2003
... Anti-Met (C-28) sc-161, anti-ERK1 (C-16) sc-93, MT1-MMP (H-72) sc-30074 anti-Calnexin (H-70) sc-11397 antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA USA) ...
Papers on Calnexin
Calnexin functions in antibacterial immunity of Marsupenaeus japonicus.
New
Wang et al., Jinan, China. In Dev Comp Immunol, 31 Oct 2014
Calnexin (Cnx) is an endoplasmic reticulum membrane-bound lectin chaperone that comprises a dedicated maturation system with another lectin chaperone calreticulin (Crt).
Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential for murine CD4(+) T cell metabolic activation.
New
Jolly et al., Austin, United States. In Biochim Biophys Acta, 31 Oct 2014
We have previously demonstrated that GPAT-1 deletion can significantly alter T cell function resulting in a T cell phenotype similar to that seen in aging.
Asiatic acid induces endoplasmic reticulum stress and apoptotic death in glioblastoma multiforme cells both in vitro and in vivo.
New
Deep et al., Aurora, United States. In Mol Carcinog, 22 Oct 2014
Furthermore, AsA induced ER stress (increased GRP78 and Calpain, and decreased Calnexin and IRE1α expression), enhanced free intra-cellular calcium, and damaged cellular organization in GBM cells.
Microarray analysis of laser-microdissected tissues indicates the biosynthesis of suberin in the outer part of roots during formation of a barrier to radial oxygen loss in rice (Oryza sativa).
New
Nakazono et al., Fukui, Japan. In J Exp Bot, Sep 2014
A semiquantitative reverse-transcription PCR analysis of genes associated with suberin biosynthesis (WRKY, CYP, and GPAT) confirmed that they were highly expressed during ROL barrier formation.
Glycerol-3-phosphate acyltransferase-4-deficient mice are protected from diet-induced insulin resistance by the enhanced association of mTOR and rictor.
New
Coleman et al., Chapel Hill, United States. In Am J Physiol Endocrinol Metab, Sep 2014
Glycerol-3-phosphate acyltransferase (GPAT) activity is highly induced in obese individuals with insulin resistance, suggesting a correlation between GPAT function, triacylglycerol accumulation, and insulin resistance.
Design, Synthesis, and Evaluation of 4- and 5-Substituted o-(Octanesulfonamido)benzoic Acids as Inhibitors of Glycerol-3-Phosphate Acyltransferase.
New
Townsend et al., Baltimore, United States. In Medchemcomm, Jul 2014
Moderate inhibition of mammalian glycerol-3-phosphate acyltransferase (GPAT) with 2-(alkanesulfonamido)benzoic acids has recently been described in vitro, accompanied by promising weight loss in vivo.
[Sn-glycerol-3-phosphate acyltransferases (GPATs) in plants].
Review
New
Xiong et al., In Yi Chuan, Dec 2013
Sn-glycerol-3-phosphate acyltransferase (GPAT) catalyzes the acylation at sn-1 position of glycerol-3-phosphate to produce lysophosphatidic acid (LPA) in an acyl-CoA or acyl-ACP-dependent manner, which is the initial and rate-determining step of TAG biosynthetic pathway.
Glycerol-3-phosphate acyltranferase-2 behaves as a cancer testis gene and promotes growth and tumorigenicity of the breast cancer MDA-MB-231 cell line.
New
Gonzalez-Baro et al., La Plata, Argentina. In Plos One, Dec 2013
The de novo synthesis of glycerolipids in mammalian cells begins with the acylation of glycerol-3-phosphate, catalyzed by glycerol-3-phosphate acyltransferase (GPAT).
Berberine induces hERG channel deficiency through trafficking inhibition.
New
Yang et al., Harbin, China. In Cell Physiol Biochem, Dec 2013
Calnexin and calreticulin, chaperones that are activated by ATF6 to assist channel folding, were also elevated and increasingly colocalized with hERG.
Identification and functional characterization of human glycerol-3-phosphate acyltransferase 1 gene promoters.
GeneRIF
Nakaya et al., Tokushima, Japan. In Biochem Biophys Res Commun, 2012
two transcriptional initiation sites and two promoters (promoter I and II) required for expression of the human GPAT1 (hGPAT1) gene were identified.
Palmitoylated calnexin is a key component of the ribosome-translocon complex.
GeneRIF
van der Goot et al., Lausanne, Switzerland. In Embo J, 2012
The findings showed that calnexin is a stable component of the ribosome-translocon complex in a manner that is exquisitely dependent on calnexin's palmitoylation status.
Bortezomib enhances radiation-induced apoptosis in solid tumors by inhibiting CIP2A.
GeneRIF
Chen et al., Taipei, Taiwan. In Cancer Lett, 2012
Bortezomib sensitized solid tumor cells to radiation-induced apoptosis through the inhibition of CIP2A.
Mice deficient in glycerol-3-phosphate acyltransferase-1 have a reduced susceptibility to liver cancer.
GeneRIF
Coleman et al., Chapel Hill, United States. In Toxicol Pathol, 2012
It was hypothesized that GPAT isoform GPAT1 might influence liver susceptibility to tumorigenesis. Data show that alterations in the formation of complex lipids catalyzed by Gpat1 reduce susceptibility to DEN-induced liver tumorigenesis.
CIP2A overexpression is associated with c-Myc expression in colorectal cancer.
GeneRIF
Haglund et al., Helsinki, Finland. In Cancer Biol Ther, 2012
Overexpression of CIP2A in colorectal cancer patients may be an important step in colorectal carcinogenesis. Based on findings, CIP2A shows no association with patient prognosis in colorectal cancer, but is associated with nuclear c-Myc.
Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis.
Review
Reue et al., Los Angeles, United States. In Am J Physiol Endocrinol Metab, 2009
The molecular identification of genes encoding enzymes that catalyze steps in TAG biosynthesis from glycerol 3-phosphate has revealed an unexpected number of protein isoforms of the glycerol phosphate acyltransferase (GPAT), acylglycerolphosphate acyltransferase (AGPAT), and lipin (phosphatidate phosphatase) families that appear to catalyze similar biochemical reactions.
Glycerol-3-phosphate acyltransferases: rate limiting enzymes of triacylglycerol biosynthesis.
Review
Coleman et al., Chapel Hill, United States. In Biochim Biophys Acta, 2009
Four homologous isoforms of glycerol-3-phosphate acyltransferase (GPAT), each the product of a separate gene, catalyze the synthesis of lysophosphatidic acid from glycerol-3-phosphate and long-chain acyl-CoA.
Thematic review series: glycerolipids. Mammalian glycerol-3-phosphate acyltransferases: new genes for an old activity.
Review
Cao et al., Cambridge, United States. In J Lipid Res, 2008
GPAT1 is the major mitochondrial GPAT isoform and is characterized by its resistance to sulfhydryl-modifying reagents, such as N-ethylmaleimide (NEM).
[Some factors, with an impact on the outcome of the Hungarian Liver Transplant Program, with special consideration of the hepatitis C virus].
Review
Nemes, Budapest, Hungary. In Magy Seb, 2008
All chaperones (XBP1, ATF6, HSP70, GRP98, GP96, Calnexin and Calreticulin) were upregulated in the graft biopsies of HCV positive patients, irrespectively of the serum HCV-RNA titer.
How do I fatten thee? Let me count the ways...
Impact
Coleman, Chapel Hill, United States. In Cell Metab, 2007
Glycerol-3-phosphate acyltransferase (GPAT) initiates the synthesis of triacylglycerol and phospholipids and, in the process, regulates the formation of several lipid metabolites known to be intracellular signaling molecules.
Roles for calreticulin and a novel glycoprotein, tapasin, in the interaction of MHC class I molecules with TAP.
Impact
Cresswell et al., New Haven, United States. In Immunity, 1996
Calnexin has previously been shown to interact with free class I heavy chains.
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