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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Jan 2016.

Calnexin

Calnexin, GPAT
This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, STEP, Insulin, CAN, HAD
Papers using Calnexin antibodies
The matrix protein of Marburg virus is transported to the plasma membrane along cellular membranes: exploiting the retrograde late endosomal pathway.
Supplier
Pekosz Andrew, In PLoS Pathogens, 2003
... Rabbit antiserum against Calnexin (Sigma Aldrich, France), mouse anti-ADRP (clone ...
Egr1 is activated by 17beta-estradiol in MCF-7 cells by mitogen-activated protein kinase-dependent phosphorylation of ELK-1
Supplier
Andre Frederic, In PLoS ONE, 2003
... Anti-Met (C-28) sc-161, anti-ERK1 (C-16) sc-93, MT1-MMP (H-72) sc-30074 anti-Calnexin (H-70) sc-11397 antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA USA) ...
Papers on Calnexin
Identification of Arabidopsis GPAT9 (At5g60620) as an Essential Gene Involved in Triacylglycerol Biosynthesis.
New
Bates et al., Pullman, United States. In Plant Physiol, 31 Jan 2016
The first step in the biosynthesis of nearly all plant membrane phospholipids and storage triacylglycerols is catalyzed by a glycerol-3-phosphate acyltransferase (GPAT).
Effects of bisphenol A on lipid metabolism in rare minnow Gobiocypris rarus.
New
Wang et al., China. In Comp Biochem Physiol C Toxicol Pharmacol, 31 Jan 2016
To evaluate the effects of BPA on lipid metabolism, we determine the hepato-somatic index, triglyceride contents in the liver and serum, the activities of acetyl-CoA carboxylase (ACC), fatty acid synthase (FASN), carnitine palmitoyltransferase (CPT1), and glycerol-3-phosphate acyltransferase (GPAT) enzymes and the mRNA expression of acaca, acacb, fasn, gpat1 and cpt1α in Gobiocypris rarus after exposure to BPA for 28days.
Arginine-induced insulin secretion in endoplasmic reticulum.
New
Imai et al., Ōbu, Japan. In Biochem Biophys Res Commun, Nov 2015
Among theses factors, Calnexin (CNX) was the only one factor, which belonged to both groups, suggesting that CNX might play a key role in arginine-induced insulin secretion in ER.
Synthesis of four (4"-, 2"-, 2'-, and 6-) monodeoxy analogs of the trisaccharide α-D-Glcp-(1 → 3)-α-D-Manp-(1 → 2)-α-D-ManpOMe recognized by Calreticulin/Calnexin.
New
Oscarson et al., Dublin, Ireland. In Carbohydr Res, Oct 2015
Routes for efficient synthesis of four (4"-, 2"-, 2'-, and 6-) monodeoxy analogs of the trisaccharide α-D-Glcp-(1 → 3)-α-D-Manp-(1 → 2)-α-D-ManpOMe have been developed.
Fermented Rhus verniciflua Stokes Extract Exerts an Antihepatic Lipogenic Effect in Oleic-Acid-Induced HepG2 Cells via Upregulation of AMP-Activated Protein Kinase.
New
Lee et al., Seoul, South Korea. In J Agric Food Chem, Sep 2015
Additionally, FRVE decreased both mRNA and protein levels of lipid-synthesis- and cholesterol-metabolism-related factors, such as sterol regulatory element-binding protein-1 (SREBP-1), fatty acid synthase (FAS), glycerol-3-phosphate acyltransferase (GPAT), and 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), in OA-induced HepG2 cells.
bZIP17 and bZIP60 Regulate the Expression of BiP3 and Other Salt Stress Responsive Genes in an UPR-Independent Manner in Arabidopsis thaliana.
New
Orellana et al., Santiago, Chile. In J Cell Biochem, Aug 2015
Here, by using insertional mutant plants on bZIP17 and bZIP60, we show that bZIP17 regulate the accumulation of the transcript for the chaperone BiP3 under salt stress conditions, but does not lead to the accumulation of UPR-responding genes such as the chaperones Calnexin, Calreticulin, and PDIL under salt treatments.
Glycerol-3-phosphate Acyltransferase Isoform-4 (GPAT4) Limits Oxidation of Exogenous Fatty Acids in Brown Adipocytes.
New
Coleman et al., Chapel Hill, United States. In J Biol Chem, Jul 2015
Glycerol-3-phosphate acyltransferase-4 (GPAT4) null pups grew poorly during the suckling period and, as adults, were protected from high fat diet-induced obesity.
Sex and depot differences in ex vivo adipose tissue fatty acid storage and glycerol-3-phosphate acyltransferase activity.
New
Jensen et al., Beijing, China. In Am J Physiol Endocrinol Metab, Jun 2015
We examined whether differences in adipose tissue glycerol-3-phosphate acyltransferase (GPAT) might play a role in these variations.
Short communication: Effect of inhibition of fatty acid synthase on triglyceride accumulation and effect on lipid metabolism genes in goat mammary epithelial cells.
New
Loor et al., Urbana, United States. In J Dairy Sci, May 2015
Inhibition of FASN in mammary cells by C75-mediated interference, a synthetic inhibitor of FASN activity, and short hairpin RNA-mediated interference markedly reduced cellular triglyceride content at least in part by decreasing the expression of genes related to triglyceride synthesis (GPAT, AGPAT6, and DGAT2) and enhancing the expression of lipolysis-related genes (ATGL and HSL).
Effects of quercetin derivatives from mulberry leaves: Improved gene expression related hepatic lipid and glucose metabolism in short-term high-fat fed mice.
New
Shiwaku et al., Izumo, Japan. In Nutr Res Pract, Apr 2015
FAS and GPAT, involved in lipid metabolism, were significantly down-regulated, and Ehhadh was significantly up-regulated.
Glycerol-3-phosphate O-acyltransferase is required for PBAN-induced sex pheromone biosynthesis in Bombyx mori.
An et al., Zhengzhou, China. In Sci Rep, 2014
Most interestingly B. mori glycerol-3-phosphate O-acyltransferase (BmGPAT) was found to be expressed during the key periods of sex pheromone biosynthesis.
Calreticulin is required for development of the cumulus oocyte complex and female fertility.
Ikawa et al., Suita, Japan. In Sci Rep, 2014
Calnexin (CANX) and calreticulin (CALR) chaperones mediate nascent glycoprotein folding in the endoplasmic reticulum.
(-)-Epicatechin-3-O-β-D-allopyranoside from Davallia formosana, Prevents Diabetes and Hyperlipidemia by Regulation of Glucose Transporter 4 and AMP-Activated Protein Kinase Phosphorylation in High-Fat-Fed Mice.
Ho et al., Taiwan. In Int J Mol Sci, 2014
BB-exerted hypotriglyceridemic activity may be partly associated with increased mRNA levels of peroxisome proliferator activated receptor α (PPARα), and with reduced hepatic glycerol-3-phosphate acyltransferase (GPAT) mRNA levels in the liver, which decreased triacylglycerol synthesis.
Identification and functional characterization of human glycerol-3-phosphate acyltransferase 1 gene promoters.
GeneRIF
Nakaya et al., Tokushima, Japan. In Biochem Biophys Res Commun, 2012
two transcriptional initiation sites and two promoters (promoter I and II) required for expression of the human GPAT1 (hGPAT1) gene were identified.
Palmitoylated calnexin is a key component of the ribosome-translocon complex.
GeneRIF
van der Goot et al., Lausanne, Switzerland. In Embo J, 2012
The findings showed that calnexin is a stable component of the ribosome-translocon complex in a manner that is exquisitely dependent on calnexin's palmitoylation status.
Bortezomib enhances radiation-induced apoptosis in solid tumors by inhibiting CIP2A.
GeneRIF
Chen et al., Taipei, Taiwan. In Cancer Lett, 2012
Bortezomib sensitized solid tumor cells to radiation-induced apoptosis through the inhibition of CIP2A.
Mice deficient in glycerol-3-phosphate acyltransferase-1 have a reduced susceptibility to liver cancer.
GeneRIF
Coleman et al., Chapel Hill, United States. In Toxicol Pathol, 2012
It was hypothesized that GPAT isoform GPAT1 might influence liver susceptibility to tumorigenesis. Data show that alterations in the formation of complex lipids catalyzed by Gpat1 reduce susceptibility to DEN-induced liver tumorigenesis.
CIP2A overexpression is associated with c-Myc expression in colorectal cancer.
GeneRIF
Haglund et al., Helsinki, Finland. In Cancer Biol Ther, 2012
Overexpression of CIP2A in colorectal cancer patients may be an important step in colorectal carcinogenesis. Based on findings, CIP2A shows no association with patient prognosis in colorectal cancer, but is associated with nuclear c-Myc.
How do I fatten thee? Let me count the ways...
Impact
Coleman, Chapel Hill, United States. In Cell Metab, 2007
Glycerol-3-phosphate acyltransferase (GPAT) initiates the synthesis of triacylglycerol and phospholipids and, in the process, regulates the formation of several lipid metabolites known to be intracellular signaling molecules.
Roles for calreticulin and a novel glycoprotein, tapasin, in the interaction of MHC class I molecules with TAP.
Impact
Cresswell et al., New Haven, United States. In Immunity, 1996
Calnexin has previously been shown to interact with free class I heavy chains.
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