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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 21 Mar 2014.

Calnexin

Calnexin, GPAT
This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, STEP, Insulin, CAN, HAD
Papers using Calnexin antibodies
The matrix protein of Marburg virus is transported to the plasma membrane along cellular membranes: exploiting the retrograde late endosomal pathway.
Supplier
Pekosz Andrew, In PLoS Pathogens, 2003
... Rabbit antiserum against Calnexin (Sigma Aldrich, France), mouse anti-ADRP (clone ...
Egr1 is activated by 17beta-estradiol in MCF-7 cells by mitogen-activated protein kinase-dependent phosphorylation of ELK-1
Supplier
Andre Frederic, In PLoS ONE, 2003
... Anti-Met (C-28) sc-161, anti-ERK1 (C-16) sc-93, MT1-MMP (H-72) sc-30074 anti-Calnexin (H-70) sc-11397 antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA USA) ...
Papers on Calnexin
Antioxidant activity of penta-oligogalacturonide, isolated from haw pectin, suppresses triglyceride synthesis in mice fed with a high-fat diet.
New
Liu et al., Shenyang, China. In Food Chem, 15 Mar 2014
Furthermore, HPPS significantly decreased the TG levels, the activity and the mRNA and protein levels of glycerol 3-phosphate acyltransferase (GPAT) and phosphatidate phosphohydrolase (PAP) in mice livers.
Effect of Carbamates on mRNA Encoding Lipid Enzymes in Hamster Flank Organs.
New
Bratoeff et al., Bogotá, Colombia. In Arch Pharm (weinheim), 03 Mar 2014
Treatments with T, P, and 7-10 increased the mRNA expression for glycerol 3-phosphate acyl transferase (GPAT), β-hydroxy-β-methylglutaryl-CoA synthase (HMG-CoA-S), β-hydroxy-β-methylglutaryl-CoA reductase (HMG-CoA-R), phosphatidylinositol synthase (PI-S), and squalene-synthase (SQ-S).
Commentary on "age-related alterations in T-lymphocytes modulate key pathways in prostate tumorigenesis." De Angulo A, Faris R, Cavazos D, Jolly C, Daniel B, DeGraffenried L, Department of Nutritional Sciences, Dell Pediatric Research Institute, University of Texas, Austin, TX, USA.: Prostate 2013;73(8):855-64 [Epub 2013 Mar 26].
New
Olumi, In Urol Oncol, 28 Feb 2014
METHODS: T-cell function of the young (<6 month-old) glycerol-3-phosphate acyltransferase-1 (GPAT-1) knock-out mouse mimics many of the hallmarks observed in an aged (>22-month-old) mouse.
Glycerol-3-phosphate Acyltransferase contributes to triacylglycerol biosynthesis, lipid droplet formation, and host invasion in Metarhizium robertsii.
New
Wang et al., Shanghai, China. In Appl Environ Microbiol, Dec 2013
Among these, the isoforms of glycerol-3-phosphate acyltransferase (GPAT) redundantly catalyze the first and rate-limiting step in glycerolipid synthesis.
[Sn-glycerol-3-phosphate acyltransferases (GPATs) in plants].
New
Xiong et al., In Yi Chuan, Dec 2013
Sn-glycerol-3-phosphate acyltransferase (GPAT) catalyzes the acylation at sn-1 position of glycerol-3-phosphate to produce lysophosphatidic acid (LPA) in an acyl-CoA or acyl-ACP-dependent manner, which is the initial and rate-determining step of TAG biosynthetic pathway.
Aralia cordata inhibits triacylglycerol biosynthesis in HepG2 cells.
New
Lee et al., South Korea. In J Med Food, Dec 2013
Glycerol-3-phosphate acyltransferase (GPAT) catalyzes the first committed step in triacylglycerol (TAG) and phospholipid biosynthesis, and has been considered as one of the drug targets for treating hepatic steatosis, insulin resistance, and other metabolic disorders.
Oleate rescues INS-1E β-cells from palmitate-induced apoptosis by preventing activation of the unfolded protein response.
New
Kiess et al., Leipzig, Germany. In Biochem Biophys Res Commun, Dec 2013
Interestingly, mRNA expression of the chaperones Bip, Pdi, Calnexin and Grp94 was not altered by FFA treatment.
RAM1 and RAM2 function and expression during arbuscular mycorrhizal symbiosis and Aphanomyces euteiches colonization.
New
Oldroyd et al., Norwich, United Kingdom. In Plant Signal Behav, Oct 2013
Among them we identified RAM (Reduced Arbuscular Mycorrhization)1 and RAM2, a GRAS transcription factor and a GPAT respectively, which are critical for the induction of hyphopodia formation in AM fungi.
Identification and functional characterization of human glycerol-3-phosphate acyltransferase 1 gene promoters.
GeneRIF
Nakaya et al., Tokushima, Japan. In Biochem Biophys Res Commun, 2012
two transcriptional initiation sites and two promoters (promoter I and II) required for expression of the human GPAT1 (hGPAT1) gene were identified.
Palmitoylated calnexin is a key component of the ribosome-translocon complex.
GeneRIF
van der Goot et al., Lausanne, Switzerland. In Embo J, 2012
The findings showed that calnexin is a stable component of the ribosome-translocon complex in a manner that is exquisitely dependent on calnexin's palmitoylation status.
Bortezomib enhances radiation-induced apoptosis in solid tumors by inhibiting CIP2A.
GeneRIF
Chen et al., Taipei, Taiwan. In Cancer Lett, 2012
Bortezomib sensitized solid tumor cells to radiation-induced apoptosis through the inhibition of CIP2A.
Mice deficient in glycerol-3-phosphate acyltransferase-1 have a reduced susceptibility to liver cancer.
GeneRIF
Coleman et al., Chapel Hill, United States. In Toxicol Pathol, 2012
It was hypothesized that GPAT isoform GPAT1 might influence liver susceptibility to tumorigenesis. Data show that alterations in the formation of complex lipids catalyzed by Gpat1 reduce susceptibility to DEN-induced liver tumorigenesis.
CIP2A overexpression is associated with c-Myc expression in colorectal cancer.
GeneRIF
Haglund et al., Helsinki, Finland. In Cancer Biol Ther, 2012
Overexpression of CIP2A in colorectal cancer patients may be an important step in colorectal carcinogenesis. Based on findings, CIP2A shows no association with patient prognosis in colorectal cancer, but is associated with nuclear c-Myc.
Glycerol-3-phosphate acyltransferases: rate limiting enzymes of triacylglycerol biosynthesis.
Review
Coleman et al., Chapel Hill, United States. In Biochim Biophys Acta, 2009
Four homologous isoforms of glycerol-3-phosphate acyltransferase (GPAT), each the product of a separate gene, catalyze the synthesis of lysophosphatidic acid from glycerol-3-phosphate and long-chain acyl-CoA.
Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis.
Review
Reue et al., Los Angeles, United States. In Am J Physiol Endocrinol Metab, 2009
The molecular identification of genes encoding enzymes that catalyze steps in TAG biosynthesis from glycerol 3-phosphate has revealed an unexpected number of protein isoforms of the glycerol phosphate acyltransferase (GPAT), acylglycerolphosphate acyltransferase (AGPAT), and lipin (phosphatidate phosphatase) families that appear to catalyze similar biochemical reactions.
Thematic review series: glycerolipids. Mammalian glycerol-3-phosphate acyltransferases: new genes for an old activity.
Review
Cao et al., Cambridge, United States. In J Lipid Res, 2008
GPAT1 is the major mitochondrial GPAT isoform and is characterized by its resistance to sulfhydryl-modifying reagents, such as N-ethylmaleimide (NEM).
[Some factors, with an impact on the outcome of the Hungarian Liver Transplant Program, with special consideration of the hepatitis C virus].
Review
Nemes, Budapest, Hungary. In Magy Seb, 2008
All chaperones (XBP1, ATF6, HSP70, GRP98, GP96, Calnexin and Calreticulin) were upregulated in the graft biopsies of HCV positive patients, irrespectively of the serum HCV-RNA titer.
Regulation of Triglyceride Metabolism. II. Function of mitochondrial GPAT1 in the regulation of triacylglycerol biosynthesis and insulin action.
Review
Coleman et al., La Plata, Argentina. In Am J Physiol Gastrointest Liver Physiol, 2007
GPAT1, one of four known glycerol-3-phosphate acyltransferase isoforms, is located on the mitochondrial outer membrane, allowing reciprocal regulation with carnitine palmitoyltransferase-1.
How do I fatten thee? Let me count the ways...
Impact
Coleman, Chapel Hill, United States. In Cell Metab, 2007
Glycerol-3-phosphate acyltransferase (GPAT) initiates the synthesis of triacylglycerol and phospholipids and, in the process, regulates the formation of several lipid metabolites known to be intracellular signaling molecules.
Roles for calreticulin and a novel glycoprotein, tapasin, in the interaction of MHC class I molecules with TAP.
Impact
Cresswell et al., New Haven, United States. In Immunity, 1996
Calnexin has previously been shown to interact with free class I heavy chains.
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