GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Calnexin
Calnexin, GPAT
This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008] (from
NCBI)
Sponsored links
Papers using
Calnexin
antibodies
The matrix protein of Marburg virus is transported to the plasma membrane along cellular membranes: exploiting the retrograde late endosomal pathway.
Supplier
In PLoS Pathogens, 2003
... Rabbit antiserum against Calnexin (Sigma Aldrich, France), mouse anti-ADRP (clone ...
Egr1 is activated by 17beta-estradiol in MCF-7 cells by mitogen-activated protein kinase-dependent phosphorylation of ELK-1
Supplier
In PLoS ONE, 2003
... Anti-Met (C-28) sc-161, anti-ERK1 (C-16) sc-93, MT1-MMP (H-72) sc-30074 anti-Calnexin (H-70) sc-11397 antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA USA) ...
Papers on
Calnexin
Alteration of proteomic profiles in PBMC isolated from patients with Fabry disease: preliminary findings.
New
Palermo, Italy. In Mol Biosyst, 05 Mar 2013
In FD patients we identified, among the down-regulated proteins, Calnexin, Rho GDP-dissociation inhibitor 2, Rho GDP-dissociation inhibitor 1, Chloride intracellular channel protein 1; on the other hand γ-enolase, 14-3-3 protein theta, 14-3-3 protein zeta/delta, and galectin-1 were identified as up-regulated proteins.
Glycerol-3-phosphate acyltransferase-1 gene ablation results in altered thymocyte lipid content and reduces thymic T cell production in mice.
New
Austin, United States. In Lipids, Jan 2013
Glycerol 3-phosphate acyltransferase-1 (GPAT-1) catalyzes the initial and rate-limiting step in de novo glycerophospholipid and triacylglycerol (TAG) biosynthesis.
A common signaling process that promotes mycorrhizal and oomycete colonization of plants.
New
Norwich, United Kingdom. In Curr Biol, Jan 2013
RAM2 encodes a glycerol-3-phosphate acyl transferase (GPAT) and is involved in the production of cutin monomers.
Apocynin administration prevents the changes induced by a fructose-rich diet on rat liver metabolism and the antioxidant system.
New
La Plata, Argentina. In Clin Sci (lond), Dec 2012
In the liver, we measured (i) NADPH oxidase activity, and gene and protein expression; (ii) protein carbonyl groups, GSH and TBARSs (thiobarbituric acid-reactive substances); (iii) catalase, CuZn-SOD (superoxide dismutase) and Mn-SOD expression; (iv) liver glycogen and lipid content; (v) GK (glucokinase), G6Pase (glucose-6-phosphatase) and G6PDH (glucose-6-phosphate dehydrogenase) activities; (vi) FAS (fatty acid synthase), GPAT (glycerol-3-phosphate acyltransferase), G6Pase and G6PDH, IL-1β (interleukin-1β), PAI-1 (plasminogen-activator inhibitor-1) and TNFα (tumour necrosis factor α) gene expression; and (vii) IκBα (inhibitor of nuclear factor κB α) protein expression.
Analysis of the enzymatic properties of a broad family of alanine aminotransferases.
New
Edmonton, Canada. In Plos One, Dec 2012
In this study we present a direct kinetic comparison of glutamate:pyruvate aminotransferase (GPAT) activity for seven AlaATs and two glutamate:glyoxylate aminotransferases (GGAT), measuring the K(M) values for the enzymes analyzed.
Inherited genetic variants in autism-related CNTNAP2 show perturbed trafficking and ATF6 activation.
New
San Diego, United States. In Hum Mol Genet, Dec 2012
BiP/Grp78, Calnexin and ERp57, key ER chaperones, appear to be responsible for retention of this mutant and activation of one signaling pathway of the unfolded protein response (UPR).
A Brucella abortus cstA mutant is defective for association with endoplasmic reticulum exit sites and displays altered trafficking in HeLa cells.
New
Namur, Belgium. In Microbiology, Oct 2012
The B. abortus cstA mutant displayed peculiar trafficking, with reduced association with LAMP1 and Calnexin 12 h post-infection in HeLa cells.
Expression of CIP2A in renal cell carcinomas correlates with tumour invasion, metastasis and patients' survival.
GeneRIF
Jinan, China. In Br J Cancer, 2012
Higher-CIP2A expression positively correlates with the aggressive phenotype of RCCs, and predicts poor prognosis for patients
Glycerol-3-phosphate acyltransferase-2 is expressed in spermatic germ cells and incorporates arachidonic acid into triacylglycerols.
La Plata, Argentina. In Plos One, 2011
BACKGROUND: De novo glycerolipid synthesis begins with the acylation of glycerol-3 phosphate catalyzed by glycerol-3-phosphate acyltransferase (GPAT).
Specialization of endoplasmic reticulum chaperones for the folding and function of myelin glycoproteins P0 and PMP22.
GeneRIF
Edmonton, Canada. In Faseb J, 2011
calnexin and ERp57, but not calreticulin, play an important role in the biology of peripheral myelin proteins PMP22 and P0, and, consequently, these chaperones may contribute to the pathogenesis of peripheral neuropathies
Prognostic role of CIP2A expression in serous ovarian cancer.
GeneRIF
Helsinki, Finland. In Br J Cancer, 2011
High Cancerous inhibitor of protein phosphatase 2A is associated with serous ovarian cancer.
Overexpression and small molecule-triggered downregulation of CIP2A in lung cancer.
GeneRIF
Beijing, China. In Plos One, 2010
Silencing CIP2A by siRNA inhibited the proliferation and clonogenic activity of lung cancer cells.
Enhanced clathrin-dependent endocytosis in the absence of calnexin.
GeneRIF
Edmonton, Canada. In Plos One, 2010
Enhanced clathrin-dependent endocytosis in the absence of calnexin may contribute to the neurological phenotype of calnexin-deficient mice
Glycerol-3-phosphate acyltransferases: rate limiting enzymes of triacylglycerol biosynthesis.
Review
Chapel Hill, United States. In Biochim Biophys Acta, 2009
Four homologous isoforms of glycerol-3-phosphate acyltransferase (GPAT), each the product of a separate gene, catalyze the synthesis of lysophosphatidic acid from glycerol-3-phosphate and long-chain acyl-CoA.
Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis.
Review
Los Angeles, United States. In Am J Physiol Endocrinol Metab, 2009
The molecular identification of genes encoding enzymes that catalyze steps in TAG biosynthesis from glycerol 3-phosphate has revealed an unexpected number of protein isoforms of the glycerol phosphate acyltransferase (GPAT), acylglycerolphosphate acyltransferase (AGPAT), and lipin (phosphatidate phosphatase) families that appear to catalyze similar biochemical reactions.
Thematic review series: glycerolipids. Mammalian glycerol-3-phosphate acyltransferases: new genes for an old activity.
Review
Cambridge, United States. In J Lipid Res, 2008
GPAT1 is the major mitochondrial GPAT isoform and is characterized by its resistance to sulfhydryl-modifying reagents, such as N-ethylmaleimide (NEM).
[Some factors, with an impact on the outcome of the Hungarian Liver Transplant Program, with special consideration of the hepatitis C virus].
Review
Budapest, Hungary. In Magy Seb, 2008
All chaperones (XBP1, ATF6, HSP70, GRP98, GP96, Calnexin and Calreticulin) were upregulated in the graft biopsies of HCV positive patients, irrespectively of the serum HCV-RNA titer.
Regulation of Triglyceride Metabolism. II. Function of mitochondrial GPAT1 in the regulation of triacylglycerol biosynthesis and insulin action.
Review
La Plata, Argentina. In Am J Physiol Gastrointest Liver Physiol, 2007
GPAT1, one of four known glycerol-3-phosphate acyltransferase isoforms, is located on the mitochondrial outer membrane, allowing reciprocal regulation with carnitine palmitoyltransferase-1.
How do I fatten thee? Let me count the ways...
Impact
Chapel Hill, United States. In Cell Metab, 2007
Glycerol-3-phosphate acyltransferase (GPAT) initiates the synthesis of triacylglycerol and phospholipids and, in the process, regulates the formation of several lipid metabolites known to be intracellular signaling molecules.
Roles for calreticulin and a novel glycoprotein, tapasin, in the interaction of MHC class I molecules with TAP.
Impact
New Haven, United States. In Immunity, 1996
Calnexin has previously been shown to interact with free class I heavy chains.
