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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

S100 calcium binding protein A9

Calgranulin B, S100A9, MRP14, MAC387
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and altered expression of this protein is associated with the disease cystic fibrosis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CagA, S-100, CAN, HAD, fibrillin-1
Papers using Calgranulin B antibodies
The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells
Supplier
Bobé Pierre, In PLoS ONE, 2009
... Murine S100A9 monoclonal antibody (mAb) was generated using the ClonaCell® – H hybridoma cloning kit (Stemcell Technologies) according to the manufacturer’s ...
Papers on Calgranulin B
Basigin (CD147), a multifunctional transmembrane glycoprotein with various binding partners.
Review
New
Muramatsu, Nagoya, Japan. In J Biochem, Jan 2016
Basigin has isoforms; the common form (basigin or basigin-2) has 2 immunoglobulin domains, and the extended form (basigin-1) has 3. Basigin is the receptor for cyclophilins, S100A9, and platelet GPVI, while basigin-1 serves as the receptor for the rod-derived cone viability factor.
Comparative Proteomic Analysis of Two Uveitis Models in Lewis Rats.
New
Van Gelder et al., In Invest Ophthalmol Vis Sci, Jan 2016
Calprotectin, a heterodimer of S100A8 and S100A9, was increased in the aqueous in both PMU and EAU.
Enhancement of radiosensitivity of lung adenocarcinoma using a decoction from the Fuzhengzengxiao formula.
New
Huang et al., In J Tradit Chin Med, Dec 2015
OBJECTIVE: To study the effects of a decoction of Fuzhengzengxiao formula on lung adenocarcinoma regarding the inflammatory protein S100A9 known to enhance cancer cell sensitivity.
S100A12 and the S100/Calgranulins: Emerging Biomarkers for Atherosclerosis and Possibly Therapeutic Targets.
Review
New
Hofmann Bowman et al., Chicago, United States. In Arterioscler Thromb Vasc Biol, Dec 2015
This review focuses on S100/calgranulin proteins (S100A8, S100A9, and S100A12) and their receptor RAGE in mediating vascular inflammation.
Correlation between myeloid-derived suppressor cells and S100A8/A9 in tumor and autoimmune diseases.
Review
New
Chen et al., Shantou, China. In Int Immunopharmacol, Dec 2015
Two calcium-binding proteins S100A8 and S100A9 act as important mediators in acute and chronic inflammation.
Beyond Cholesterol - New Cardiovascular Biomarkers.
New
Mangge, In Nestle Nutr Inst Workshop Ser, Dec 2015
New biomarkers in these mechanisms include pentraxin 3, calprotectins S100A8/S100A9, myeloperoxidase, adiponectin, interleukins, and chemokines.
Serum S100A8 and S100A9 Enhance Innate Immune Responses in the Pathogenesis of Baker's Asthma.
Park et al., Suwŏn, South Korea. In Int Arch Allergy Immunol, 2014
BACKGROUND: S100A8 and S100A9 can be produced by lipopolysaccharide-stimulated granulocytes and provoke an innate immune-mediated airway inflammation.
S100A9 as a Pharmacological Target Molecule in Inflammation and Cancer.
Review
Ivars et al., Lund, Sweden. In Endocr Metab Immune Disord Drug Targets, 2014
Our laboratory is interested in the S100A9 protein, a bona fide DAMP protein.
Downregulation of S100 Calcium Binding Protein A9 in Esophageal Squamous Cell Carcinoma.
Kumar et al., Bengaluru, India. In Scientificworldjournal, 2014
A total of 238 differentially expressed proteins were identified in that study including S100 calcium binding protein A9 (S100A9) as one of the major downregulated proteins.
Target-selective protein S-nitrosylation by sequence motif recognition.
Impact
Fox et al., Cleveland, United States. In Cell, 2014
Here, we describe a stimulus-inducible, heterotrimeric S-nitrosylase complex consisting of inducible NOS (iNOS), S100A8, and S100A9.
S100A8-S100A9 protein complex mediates psoriasis by regulating the expression of complement factor C3.
Impact
Wagner et al., Madrid, Spain. In Immunity, 2014
Here we performed proteomic analyses of human psoriatic epidermis and found S100A8-S100A9, also called calprotectin, as the most upregulated proteins, followed by the complement component C3.
Hyperglycemia promotes myelopoiesis and impairs the resolution of atherosclerosis.
Impact
Goldberg et al., New York City, United States. In Cell Metab, 2013
Increased neutrophil production of S100A8/S100A9, and its subsequent interaction with the receptor for advanced glycation end products on common myeloid progenitor cells, leads to enhanced myelopoiesis.
Tumor necrosis factor-α blocks differentiation and enhances suppressive activity of immature myeloid cells during chronic inflammation.
Impact
Baniyash et al., Canada. In Immunity, 2013
Here we showed that TNF-α exhibited a dual function during chronic inflammation: arresting differentiation of immature myeloid-derived suppressor cells (MDSCs) primarily via the S100A8 and S100A9 inflammatory proteins and their corresponding receptor (RAGE) and augmenting MDSC suppressive activity.
Biomarkers in Exhaled Breath Condensate and Serum of Chronic Obstructive Pulmonary Disease and Non-Small-Cell Lung Cancer.
Review
Thomas et al., Sydney, Australia. In Int J Chronic Dis, 2012
In the serum, S100A8, S100A9, and S100A12 of the S100 proteins are proinflammatory markers.
Induction of nuclear factor-κB responses by the S100A9 protein is Toll-like receptor-4-dependent.
GeneRIF
Leanderson et al., Lund, Sweden. In Immunology, 2012
S100A9 induced stronger NF-kappaB activation albeit weaker cytokine secretion than LPS, suggesting that S100A9 and LPS activated NF-kappaB in a qualitatively distinct manner
Identification of the up-regulation of TP-alpha, collagen alpha-1(VI) chain, and S100A9 in esophageal squamous cell carcinoma by a proteomic method.
GeneRIF
Meng et al., Luoyang, China. In J Proteomics, 2012
TP-alpha, collagen alpha-1(VI) chain and S100A9 are potential biomarkers of esophageal squamous cell carcinoma, and may play an important role in tumorigenesis and development of ESCC.
S100A8 and S100A9 are messengers in the crosstalk between epidermis and dermis modulating a psoriatic milieu in human skin.
GeneRIF
Lee et al., Taejŏn, South Korea. In Biochem Biophys Res Commun, 2012
the upregulated production of S100A8 and S100A9 by psoriatic epidermal keratinocytes activated adjacent keratinocytes to produce several cytokines.
Oncogenic Kras expression in postmitotic neurons leads to S100A8-S100A9 protein overexpression and gliosis.
GeneRIF
Zhang et al., Madison, United States. In J Biol Chem, 2012
Our results identify overexpression of S100A8-S100A9 in neurons as an early step in oncogenic Kras-induced gliosis.
The role of myofibroblasts in upregulation of S100A8 and S100A9 and the differentiation of myeloid cells in the colorectal cancer microenvironment.
GeneRIF
Kim et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2012
The upregulation of S100A8/A9 in tumor-infiltrated myeloid cells could be triggered by IL-6 and IL-8 released from myofibroblasts.
Phase II randomized, double-blind, placebo-controlled study of tasquinimod in men with minimally symptomatic metastatic castrate-resistant prostate cancer.
Impact
Armstrong et al., Buffalo, United States. In J Clin Oncol, 2011
PURPOSE: The activity of the novel antitumor agent tasquinimod (TASQ) with S100A9 as a molecular target was investigated in men with metastatic castration-resistant prostate cancer (CRPC) and minimal symptoms.
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