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Caldesmon 1

Caldesmon, DFF40, caspase-activated deoxyribonuclease
This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Actin, PrP, ICAD, TM3, CAN
Papers using Caldesmon antibodies
Follicular dendritic cell sarcoma in the lymph nodes of the neck
Supplier
Adam Patrick et al., In Diagnostic Pathology, 2006
... CaldesmonDAKO ...
Papers on Caldesmon
An intrinsic DFF40/CAD endonuclease deficiency impairs oligonucleosomal DNA hydrolysis during caspase-dependent cell death: a common trait in human glioblastoma cells.
New
Yuste et al., Barcelona, Spain. In Neuro Oncol, Feb 2016
The loss of DFF40/CAD, the key endonuclease that triggers oligonucleosomal DNA fragmentation during apoptosis, has been linked to genomic instability and cell survival after radiation.
Sensitization of breast cancer cells to doxorubicin via stable cell line generation and overexpression of DFF40.
New
Sheibani et al., Tehrān, Iran. In Biochem Cell Biol, Dec 2015
There are a number of reports demonstrating a relationship between the alterations in DFF40 expression and development of some cancers.
Evolution of Flow-Diverter Endothelialization and Thrombus Organization in Giant Fusiform Aneurysms after Flow Diversion: A Histopathologic Study.
New
Marosfoi et al., Budapest, Hungary. In Ajnr Am J Neuroradiol, Sep 2015
Formaldehyde-fixed paraffin-embedded sections were stained by using H&E, Van Gieson elastic, CD34, h-Caldesmon, and Picrosirius stains and studied by light microscopy.
Primary malignant myopericytoma of the left atrium--a tumor of aggressive biological behavior: report of the first case and review of literature.
Review
New
Iwenofu et al., Columbus, United States. In Appl Immunohistochem Mol Morphol, Jul 2015
By immunohistochemistry, the cells were positive for smooth muscle actin and negative for desmin, H-Caldesmon, S-100, HMB-45, and Melan-A.
Obesity and ischemic stroke modulate the methylation levels of KCNQ1 in white blood cells.
New
Campión et al., Pamplona, Spain. In Hum Mol Genet, Apr 2015
One CpG site at Caldesmon 1 (CALD1) gene showed an interaction between stroke and obesity.
Structural insight into CIDE domains: the Janus face of CIDEs.
Review
New
Park, Kyŏngsan, South Korea. In Apoptosis, Feb 2015
Cell-death inducing DFF45-like effect domain (CIDE domain) is a protein interaction module that was initially found in DNA fragmentation factor (DFF) proteins DFF40 and DFF45.
Neuroprotective effect of water extract of Panax ginseng on corticosterone-induced apoptosis in PC12 cells and its underlying molecule mechanisms.
New
Pan et al., Beijing, China. In J Ethnopharmacol, Feb 2015
Then, mitochondrial permeability transition pore (mPTP), mitochondrial membrane potential (MMP), intracellular Ca(2+) ([Ca(2+)]i), reactive oxygen species (ROS) concentration, and the expression level of glucocorticoid receptor (GR), heat shock protein 90 (Hsp90), histone deactylase 6 (HDAC6), glucose-regulated protein 78 (GRP78), growth arrest and DNA damage inducible protein 153 (GADD153), X-box DNA-binding protein-1 (XBP-1), caspase-12, cytochrome C, inhibitor of caspase-activated deoxyribonuclease (ICAD), caspase-3 and caspase-9 were assessed by Western Blot analysis to understand the molecule mechanisms of neuroprotection of WEG.
New insights into pathophysiological mechanisms regulating conventional aqueous humor outflow.
Review
Janulevičienė et al., Kaunas, Lithuania. In Medicina (kaunas), 2012
Caldesmon negatively regulates actin-myosin interactions and thus increases outflow.
Human papillomavirus type 16 E6 protein inhibits DNA fragmentation via interaction with DNA fragmentation factor 40.
GeneRIF
Seo et al., Seoul, South Korea. In Cancer Lett, 2012
Human papillomavirus type 16 E6 protein inhibits DNA fragmentation via interaction with DNA fragmentation factor 40
Apoptotic DNA degradation into oligonucleosomal fragments, but not apoptotic nuclear morphology, relies on a cytosolic pool of DFF40/CAD endonuclease.
GeneRIF
Yuste et al., Barcelona, Spain. In J Biol Chem, 2012
the cytosolic levels of DFF40/CAD are determinants in achieving a complete apoptotic phenotype, including oligonucleosomal DNA degradation.
Smooth muscle caldesmon modulates peristalsis in the wild type and non-innervated zebrafish intestine.
GeneRIF
Pack et al., Philadelphia, United States. In Neurogastroenterol Motil, 2012
Disruption of the normal inhibitory function of human caldesmon 1 enhances intestinal peristalsis in both wild-type zebrafish larvae and mutant larvae that lack enteric nerves
Early apoptotic reorganization of spliceosomal proteins involves caspases, CAD and rearrangement of NuMA.
GeneRIF
Muller et al., Strasbourg, France. In Traffic, 2012
During apoptotic rearrangement of interchromatin granule clusters, the nuclear matrix (NuMa rearrangement) and chromatin are closely associated. This process occurs in defined stages and depends on the activity of protein phosphatases, caspases and CAD.
Caldesmon regulates axon extension through interaction with myosin II.
GeneRIF
Sobue et al., Suita, Japan. In J Biol Chem, 2012
caldesmon is an important regulator of axon development.
Diversification of caldesmon-linked actin cytoskeleton in cell motility.
Review
GeneRIF
Sobue et al., Ōsaka, Japan. In Cell Adh Migr, 2011
Caldesmon binds and stabilizes actin filaments, as well as regulates actin-myosin interaction in a calcium (Ca2+)/calmodulin (CaM)- and/or phosphorylation-dependent manner. (Review)
Chapter 1: roles of caldesmon in cell motility and actin cytoskeleton remodeling.
Review
Jin et al., Iowa City, United States. In Int Rev Cell Mol Biol, 2008
A single gene (CALD1) encodes high molecular mass CaD (h-CaD) and low molecular mass CaD (l-CaD) by alternative splicings.
Endonuclease G is an apoptotic DNase when released from mitochondria.
Impact
Wang et al., Dallas, United States. In Nature, 2001
One such nuclease, DNA fragmentation factor (DFF, a caspase-activated deoxyribonuclease (CAD) and its inhibitor (ICAD)), is capable of inducing DNA fragmentation and chromatin condensation after cleavage by caspase-3 (refs 2,3,4).
DFF45/ICAD can be directly processed by granzyme B during the induction of apoptosis.
Impact
Ley et al., Saint Louis, United States. In Immunity, 2000
In this report, we demonstrate that GzmB can initiate apoptosis in the absence of caspase-3 activity by directly cleaving DFF45/ICAD to liberate activated DFF40/CAD.
Solution structure of the CIDE-N domain of CIDE-B and a model for CIDE-N/CIDE-N interactions in the DNA fragmentation pathway of apoptosis.
Impact
Wagner et al., Cambridge, United States. In Cell, 2000
Apoptotic DNA fragmentation and chromatin condensation are mediated by the caspase-activated DFF40/ CAD nuclease, which is chaperoned and inhibited by DFF45/ICAD.
Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation.
Impact
Tsujimoto et al., Suita, Japan. In Nature, 1999
These changes are triggered by the activation of a family of cysteine proteases called caspases, and caspase-activated DNase (CAD/DFF40) and lamin protease (caspase-6) have been implicated in some of these changes.
Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis.
Impact
Nagata et al., Suita, Japan. In Nature, 1998
In the accompanying Article, we have identified and molecularly cloned a caspase-activated deoxyribonuclease (CAD) and its inhibitor (ICAD).
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