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S100 calcium binding protein A6

calcyclin, S100A6
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: S-100, S100A4, CAN, ACID, S100A2
Papers on calcyclin
Lipoaspirate fluid proteome: A preliminary investigation by LC-MS top-down/bottom-up integrated platform of a high potential biofluid in regenerative medicine.
New
Lattanzi et al., Roma, Italy. In Electrophoresis, Jan 2016
VV- and LVV-hemorphin-7), thymosins β4 and β10 peptides, ubiquitin and acyl-CoA binding protein; adipogenesis regulatory factor, perilipin-1 fragments, and S100A6, along with their PTMs.
Expression and regulation of CacyBP/SIP in chronic lymphocytic leukemia cell balances of cell proliferation with apoptosis.
New
Xu et al., Xuzhou, China. In J Cancer Res Clin Oncol, Dec 2015
The calcyclin-binding protein/Siah-1-interacting protein (CacyBP/SIP) plays a pivotal role in tumorigenicity and cell apoptosis.
Influence of doxazosin on biosynthesis of S100A6 and atrial natriuretic factor peptides in the heart of spontaneously hypertensive rats.
New
Majewski et al., Białystok, Poland. In Exp Biol Med (maywood), Nov 2015
To better understand the cellular processes and signaling pathways responsible for the proper functioning of the heart, we decided to check whether doxazosin affects the density of structures containing S100A6 and atrial natriuretic factor in the heart of spontaneously hypertensive rats.
Evaluation and screening of mRNA S100A genes as serological biomarkers in different stages of bladder cancer in Egypt.
New
Abozeed et al., Cairo, Egypt. In Tumour Biol, Nov 2015
Both S100A4 and S100A6 can be used to differentiate between different stages of bladder cancer.
S100A6 expression in cutaneous smooth muscle neoplasms.
New
Elston et al., New York City, United States. In Apmis, Oct 2015
The S100A6 protein is expressed in a variety of tissues and distinct staining patterns in S100A6 immunohistochemistry may be useful in the differential diagnosis of difficult lesions.
Diagnostic significance of S100A2 and S100A6 levels in sera of patients with non-small cell lung cancer.
New
Ren et al., Xi'an, China. In Tumour Biol, Oct 2015
Recent studies have demonstrated a link involving S100 Calcium Binding Proteins (S100A2, S100A6) and non-small cell lung cancer (NSCLC), but the expediency of their serum levels in NSCLC has not been established.
The Calcium-Binding Protein S100A6 Accelerates Human Osteosarcoma Growth by Promoting Cell Proliferation and Inhibiting Osteogenic Differentiation.
He et al., In Cell Physiol Biochem, 2014
We previously found the calcium-binding protein S100A6 was expressed in ∼80% of the analyzed OS primary and/or metastatic tumor samples.
Antigen-Antibody Affinity for Dry Eye Biomarkers by Label Free Biosensing. Comparison with the ELISA Technique.
Casquel et al., Madrid, Spain. In Sensors (basel), 2014
Different proteins involved with dry eye dysfunction: ANXA1, ANXA11, CST4, PRDX5, PLAA and S100A6; were validated as biomarkers.
Role of endoscopic ultrasound in the molecular diagnosis of pancreatic cancer.
Review
Buscail et al., Toulouse, France. In World J Gastroenterol, 2014
Similar approaches are conducted using analysis of miRNA expression as well as Mucin or markers of invasion (S100P, S100A6, PLAT or PLAU).
Joining S100 proteins and migration: for better or for worse, in sickness and in health.
Review
Rudland et al., Birmingham, United Kingdom. In Cell Mol Life Sci, 2014
This review summarises some of the reported regulatory functions of S100 proteins (namely S100A1, S100A2, S100A4, S100A6, S100A7, S100A8/S100A9, S100A10, S100A11, S100A12, S100B and S100P) on cellular migration and invasion, established in both culture and animal model systems and the possible mechanisms that have been proposed to be responsible.
Annexin A11 in disease.
Review
Greenaway et al., Dalian, China. In Clin Chim Acta, 2014
In a variety of diseases, Anxa11 is most commonly reported to function through interactions with apoptosis-linked gene-2 protein (ALG-2) and/or calcyclin (S100A6).
S100 family signaling network and related proteins in pancreatic cancer (Review).
Review
Xiao et al., Nantong, China. In Int J Mol Med, 2014
Recently, S100A2 has been suggested to be a negative prognostic biomarker in pancreatic cancer, and the expression of S100A6 may be an independent prognostic impact factor.
S100A6 is transcriptionally regulated by β-catenin and interacts with a novel target, lamin A/C, in colorectal cancer cells.
GeneRIF
Filipek et al., Warsaw, Poland. In Cell Calcium, 2012
S100A6 interacts with lamin A/C, a protein known to be implicated in colon carcinogenesis.
Expression and purification of bioactive high-purity human S100A6 in Escherichia coli.
GeneRIF
Yu et al., Shanghai, China. In Protein Expr Purif, 2012
Introduced a simple and efficient method for producing high-purity recombinant human S100A6 from Escherichia coli culture with low level of endotoxin. We further demonstrated its biological activities for triggering SH-SY5Y cells apoptosis in vitro.
S100-A10, thioredoxin, and S100-A6 as biomarkers of papillary thyroid carcinoma with lymph node metastasis identified by MALDI imaging.
GeneRIF
Zitzelsberger et al., München, Germany. In J Mol Med (berl), 2012
the overexpression of thioredoxin,S100-A10 and S100-A6 specifically distinguished metastatic from non-metastatic tumors
Matrix-assisted laser desorption/ionization mass spectrometry reveals decreased calcylcin expression in small cell lung cancer.
GeneRIF
Kim et al., South Korea. In Pathol Int, 2012
Calcyclin was identified to be underexpressed in small cell lung cancers, as compared with non-small cell lung cancers and normal lung tissue.
Calcium-binding protein S100P and cancer: mechanisms and clinical relevance.
Review
Zhang et al., Hangzhou, China. In J Cancer Res Clin Oncol, 2012
S100P has been shown to mediate tumor growth, metastasis and invasion through the binding of Ca(2+) ions, receptor for advanced glycation end products, cytoskeletal protein ezrin, calcyclin-binding protein/Siah-1-interacting protein and cathepsin D. S100P could potentially serve as diagnostic marker, prognostic/predictive indicator and therapy target for different carcinomas.
S100A6 protein negatively regulates CacyBP/SIP-mediated inhibition of gastric cancer cell proliferation and tumorigenesis.
GeneRIF
Wang et al., Xi'an, China. In Plos One, 2011
new insight into the interaction between S100 proteins and CacyBP/SIP
Comparative proteomic analysis of differentially expressed proteins in an in vitro cellular carcinogenesis model of oral squamous cell carcinoma.
Zhang et al., Shanghai, China. In Proteomics Clin Appl, 2009
Further validation of five identified proteins (ANXA1, ANXA2, CTSB, KRT17, and S100A6) in the cellular carcinogenesis model and cancerous tissues from OSCC patients confirmed the comparative proteomic results.
Ionomycin-regulated phosphorylation of the myeloid calcium-binding protein p14.
Impact
Hogg et al., Lincoln, United Kingdom. In Nature, 1989
These proteins are members of a family of CaBPs of low Mr, which include S-100 alpha and beta proteins, calcyclin (2A9), intestinal CaBP and p11.
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