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Calcitonin-related polypeptide alpha

Calcitonin, Calcitonin Gene-Related Peptide, CGRP
This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009] (from NCBI)
Top mentioned proteins: CAN, Neuropeptide, HAD, V1a, TRPV1
Papers using Calcitonin antibodies
Structure of an agonist-bound human A2A adenosine receptor
Supplier
Poyner David R. et al., In Biochimica et Biophysica Acta, 2010
... histidyl-human αCGRP was from PerkinElmer Life and Analytical Sciences ...
Ab initio folding of terminal segments with secondary structures reveals the fine difference between two closely related all-atom statistical energy functions
Supplier
Poyner David R. et al., In Peptides, 2007
... histidyl-human αCGRP was from PerkinElmer Life and Analytical Sciences ...
Protein–protein interaction and not glycosylation determines the binding selectivity of heterodimers between the calcitonin receptor-like receptor and the receptor activity-modifying proteins
Supplier
Donnelly Dan et al., In Biochemical and Biophysical Research Communications, 2000
... Human α-CGRP (herein referred to as CGRP) was purchased from Bachem (Saffron Walden, UK) ...
Central poststroke pain and Wallenberg's lateral medullary infarction: Frequency, character, and determinants in 63 patients.
Supplier
Premkumar Louis S., In PLoS ONE, 1996
... Corp.), substance P receptor (rabbit NK-1; 1∶7,500; Chemicon, Temecula, CA, USA), calcitonin gene-related peptide (guinea pig anti-CGRP; 1∶5,000; Peninsula Laboratories [now Bachem AG; Torrance, CA, USA]), ...
Structure and energetics of ligand binding to proteins: Escherichia coli dihydrofolate reductase-trimethoprim, a drug-receptor system
Supplier
Porter James E et al., In BMC Pharmacology, 1987
... -CGRP(8–37) was a gift from Phoenix Pharmaceuticals (Belmont, CA) ...
Papers on Calcitonin
Laboratory tests of headache disorders - dawn of a new era?
Review
New
Olesen et al., Glostrup, Denmark. In Cephalalgia, Feb 2016
Provocation tests with glyceryl trinitrate (GTN) and calcitonin gene-related peptide (CGRP) may be valuable in subclassification of migraine and cluster headache.
Effect of cannabinoids on CGRP release in the isolated rat lumbar spinal cord.
New
Ashton et al., Dunedin, New Zealand. In Neurosci Lett, Feb 2016
It has been proposed that one mechanism is by modulating the release of CGRP in the spinal cord pain pathways.
Challenges in developing drugs for primary headache.
Review
New
Ashina et al., Copenhagen, Denmark. In Prog Neurobiol, Feb 2016
The development of the triptan class of serotonin 5-HT1B/1D/1F receptor agonists has advanced our understanding of the neurobiology of migraine pain, which subsequently resulted in the development of calcitonin gene related peptide (CGRP) modulators that are now showing promise as acute and preventative anti-migraine agents.
The nuclear molecular imaging of protein brain receptors in chronic pain.
Review
New
Huang et al., Changsha, China. In Curr Protein Pept Sci, Feb 2016
Brain receptors, such as the opioid receptors, dopamine receptors, NK-1 receptors, 5-HT receptors, NMDA receptors and CGRP receptors, are effector sites of neurotransmission and have prominent roles in pain generation and modulation.
Endomorphin Analog Analgesics with Reduced Abuse Liability, Respiratory Depression, Motor Impairment, Tolerance, and Glial Activation.
New
Fasold et al., New Orleans, United States. In Neuropharmacology, Jan 2016
At doses providing equal or greater antinociception than morphine in the rat, the analogs showed reduced a) respiratory depression, b) impairment of motor coordination, c) tolerance and hyperalgesia, d) glial p38/CGRP/P2X7 receptor signaling, and e) reward/abuse potential in both conditioned place preference and self-administration tests.
Alterations of neurochemical expression of the coeliac-superior mesenteric ganglion complex (CSMG) neurons supplying the prepyloric region of the porcine stomach following partial stomach resection.
New
Całka et al., Olsztyn, Poland. In J Chem Neuroanat, Jan 2016
Furthermore, FB-positive neurons in all pigs were surrounded by a network of cocaine- and amphetamine-regulated transcript peptide (CART)-, calcitonin gene-related peptide (CGRP)-, and substance P (SP)-, vasoactive intestinal peptide (VIP)-, LENK- and nNOS- immunoreactive nerve fibers.
Environmental cold exposure increases blood flow and affects pain sensitivity in the knee joints of CFA-induced arthritic mice in a TRPA1-dependent manner.
New
Brain et al., São Luís, Brazil. In Arthritis Res Ther, Dec 2015
Blood flow was assessed after pretreatment with antagonists of either TRPA1 (HC-030031), substance P neurokinin 1 (NK1) receptors (SR140333) or calcitonin gene-related peptide (CGRP) (CGRP8-37).
Safety, tolerability, and efficacy of TEV-48125 for preventive treatment of high-frequency episodic migraine: a multicentre, randomised, double-blind, placebo-controlled, phase 2b study.
New
Impact
Lipton et al., United States. In Lancet Neurol, Nov 2015
BACKGROUND: Calcitonin gene-related peptide (CGRP) is a validated target for the treatment of episodic migraine.
Safety, tolerability, and efficacy of TEV-48125 for preventive treatment of chronic migraine: a multicentre, randomised, double-blind, placebo-controlled, phase 2b study.
New
Impact
Silberstein et al., United States. In Lancet Neurol, Nov 2015
BACKGROUND: Benefits of calcitonin-gene related peptide (CGRP) inhibition have not been established in chronic migraine.
New therapeutic approaches for the prevention and treatment of migraine.
Review
New
Impact
Holle et al., Essen, Germany. In Lancet Neurol, Oct 2015
Successful new approaches for the treatment of acute migraine target calcitonin gene-related peptide (CGRP) and serotonin (5-hydroxytryptamine, 5-HT1F) receptors.
Elucidating an Affective Pain Circuit that Creates a Threat Memory.
New
Impact
Palmiter et al., Seattle, United States. In Cell, Aug 2015
Here, we show that neurons expressing calcitonin gene-related peptide (CGRP) in the parabrachial nucleus are critical for relaying pain signals to the central nucleus of amygdala and that this pathway may transduce the affective motivational aspects of pain.
[Effect of alcohol on vascular function].
Review
New
Hatake et al., In Nihon Arukoru Yakubutsu Igakkai Zasshi, Jun 2015
Furthermore, acute ethanol ingestion can also potentiate and suppress calcitonin gene-related peptide (CGRP)-induced nerve-mediated relaxation.
The Role of the Paratrigeminal Nucleus in Vagal Afferent Evoked Respiratory Reflexes: A Neuroanatomical and Functional Study in Guinea Pigs.
McGovern et al., Australia. In Front Physiol, 2014
Whereas, nodose neurons more often expressed 160 KD neurofilament proteins and the alpha3 subunit of Na(+)/K(+) ATPase, significantly more jugular neurons expressed the neuropeptides substance P (SP) and, especially, Calcitonin Gene-Related Peptide (CGRP).
New players in the preventive treatment of migraine.
Review
Rapoport et al., Athens, Greece. In Bmc Med, 2014
Recently, three monoclonal antibodies targeting the calcitonin gene-related peptide (CGRP) ligand (LY2951742, ALD403 and TEV-48125) and one targeting the CGRP receptor (AMG 334) have completed phase 2 trials, and the results have been reported.
Calcitonin gene-related peptide (CGRP): a new target for migraine.
Review
Impact
Russo, In Annu Rev Pharmacol Toxicol, 2014
The neuropeptide calcitonin gene-related peptide (CGRP) is now firmly established as a key player in migraine.
Procalcitonin and sepsis: recent data on diagnostic utility prognostic potential and therapeutic implications in critically ill patients.
GeneRIF
Tsangaris et al., Athens, Greece. In Minerva Anestesiol, 2012
Procalcitonin has emerged as the most specific biomarker for bacterial infection
Calcitonin gene-related peptide, heme oxygenase-1, endothelial progenitor cells and nitric oxide-dependent vasodilation relationships in a human model of angiotensin II type-1 receptor antagonism.
GeneRIF
Rossi et al., Padova, Italy. In J Hypertens, 2012
Using a human model opposite to hypertension, this study provides information on the relationships between CGRP, heme oxygenase-1, FMD, major clinical and biochemical factors involved in cardiovascular disease, and EPC-specific populations
Peptidomics approach to elucidate the proteolytic regulation of bioactive peptides.
GeneRIF
Saghatelian et al., Seoul, South Korea. In Proc Natl Acad Sci U S A, 2012
Data show that in the absence of insulin-degrading enzyme (IDE), full-length calcitonin gene-related peptide (CGRP) levels are elevated in vivo.
CGRPα-expressing sensory neurons respond to stimuli that evoke sensations of pain and itch.
GeneRIF
Zylka et al., Chapel Hill, United States. In Plos One, 2011
Data show that calcitonin gene-related peptide (CGRPalpha(+) dorsal root ganglia (DRG) neurons respond to agonists that evoke pain and itch and constitute a sensory circuit that is largely distinct from nonpeptidergic circuits.
Topographical organization of TRPV1-immunoreactive epithelium and CGRP-immunoreactive nerve terminals in rodent tongue.
GeneRIF
Sato et al., Tokyo, Japan. In Eur J Histochem, 2011
the TRPV1-expressing epithelium monitors the oral environment and acquired information may then be conducted to the adjacent CGRP-expressing terminals.
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