Functional Analysis of the Adrenomedullin Pathway in Malignant Pleural Mesothelioma.
Marseille, France. In J Thorac Oncol, Jan 2016
Adrenomedullin (AM) is a multifunctional peptide that is highly expressed in several tumors and plays an important role in angiogenesis and tumor growth after binding to its receptors, calcitonin receptor-like receptor/receptor activity-modifying protein 2 (CLR/RAMP2) and calcitonin receptor-like receptor/receptor activity-modifying protein 3 (CLR/RAMP3).
Endogenous VMH amylin signaling is required for full leptin signaling and protection from diet-induced obesity.
Zürich, Switzerland. In Am J Physiol Regul Integr Comp Physiol, Jan 2016
Since DIO (125)I-amylin dorsomedial nucleus (DMN)-dorsomedial VMN (VMNdm) binding was reduced, we postulated that this contributed to DIO VMH leptin resistance and that impairing ventromedial hypothalamic (VMH: ARC + VMN) CTR-mediated signaling by injecting adeno-associated virus (AAV) expressing a short hairpin calcitonin receptor (CTR) would predispose diet-resistant (DR) rats to obesity on high fat (45%) diet (HFD).
Bench-to-bedside pharmacology of adrenomedullin.
Miyazaki, Japan. In Eur J Pharmacol, Nov 2015
These activities are assumed to be mediated via the specific receptor formed by calcitonin receptor-like receptor and receptor activity-modifying protein 2 or 3, while some questions remain to be answered about the molecular mechanisms of this signal transduction system.
Roles of CLR/RAMP receptor signaling in reproduction and development.
Taiwan. In Curr Protein Pept Sci, 2013
Recent research into their functions in reproduction has illuminated the role of these peptides and their cognate receptors (calcitonin receptor-like receptor/receptor activity-modifying protein (CLR/RAMP) receptors) in fetal-maternal blood circulation, fetoplacental development, female gamete development, and gamete movement in the oviduct.