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Calcitonin receptor-like

calcitonin receptor-like receptor, CRLR
G-protein coupled receptor for either calcitonin gene-related peptide or adrenomedullin that may play a role in vascular tone [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Calcitonin, adrenomedullin, RAMP1, V1a, CAN
Papers on calcitonin receptor-like receptor
Synovial macrophage-derived IL-1β regulates the calcitonin receptor in osteoarthritic mice.
New
Takaso et al., Sagamihara, Japan. In Clin Exp Immunol, Jan 2016
Real-time polymerase chain reaction (PCR) was used to evaluate the expression of interleukin (IL)-1β, CGRP, calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 1 (RAMP1) in F4/80(+) and F4/80(-) cells.
Functional Analysis of the Adrenomedullin Pathway in Malignant Pleural Mesothelioma.
New
Ouafik et al., Marseille, France. In J Thorac Oncol, Jan 2016
Adrenomedullin (AM) is a multifunctional peptide that is highly expressed in several tumors and plays an important role in angiogenesis and tumor growth after binding to its receptors, calcitonin receptor-like receptor/receptor activity-modifying protein 2 (CLR/RAMP2) and calcitonin receptor-like receptor/receptor activity-modifying protein 3 (CLR/RAMP3).
Role of cerebellar adrenomedullin in blood pressure regulation.
New
Israel et al., Caracas, Venezuela. In Neuropeptides, Dec 2015
Adrenomedullin (AM) and their receptor components, calcitonin-receptor-like receptor (CRLR) and receptor activity-modifying protein (RAMP1, RMP2 and RAMP3) are widely expressed in the central nervous system, including cerebellum.
Pregnancy Increases Relaxation in Human Omental Arteries to the CGRP Family of Peptides.
New
Yallampalli et al., Houston, United States. In Biol Reprod, Dec 2015
By using resistance omental arteries collected from nonpregnant women (n = 15) during laparotomy and from term pregnant women (n = 15) at cesarean delivery, this study shows that the receptor components-calcitonin receptor-like receptor (CALCRL) and receptor activity-modifying proteins (RAMPs) 1, 2 and 3-are localized to endothelial and smooth muscle cells in omental arteries, with increased expressions of both mRNA and protein in pregnant compared with nonpregnant women.
Fluorescently labeled adrenomedullin allows real-time monitoring of adrenomedullin receptor trafficking in living cells.
New
Beck-Sickinger et al., Leipzig, Germany. In J Pept Sci, Dec 2015
For potential use in clinical applications, we aimed to investigate the fate of the peptide ligand after binding and activation of the adrenomedullin receptor (AM1 ), a heterodimer consisting of the calcitonin receptor-like receptor (CLR), a G protein-coupled receptor, associated with the receptor activity-modifying protein 2 (RAMP2).
Involvement of Receptor Activity-Modifying Protein 3 (RAMP3) in the Vascular Actions of Adrenomedullin in Rat Mesenteric Artery Smooth Muscle Cells.
New
Yallampalli et al., Houston, United States. In Biol Reprod, Nov 2015
CALCB, ADM, and ADM2 are potent vasodilators that share a seven-transmembrane GPCR, calcitonin receptor-like receptor (CALCRL), whose ligand specificity is dictated by the presence of one of the three receptor activity-modifying proteins (RAMPs).
Bench-to-bedside pharmacology of adrenomedullin.
Review
New
Kitamura et al., Miyazaki, Japan. In Eur J Pharmacol, Nov 2015
These activities are assumed to be mediated via the specific receptor formed by calcitonin receptor-like receptor and receptor activity-modifying protein 2 or 3, while some questions remain to be answered about the molecular mechanisms of this signal transduction system.
Kynurenic acid modulates experimentally induced inflammation in the trigeminal ganglion.
Warfvinge et al., Szeged, Hungary. In J Headache Pain, 2014
We investigated changes of mitogen-activated protein kinases (MAPKs as ERK1/2, p38 and SAPK/JNK), NF-κB, CaMKII and DREAM, in addition to calcitonin gene-related peptide (CGRP) and its receptor components calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 1 (RAMP1) in the TG, with immunohistochemistry and Western blot at 2 and 10 days post-CFA injection.
Calcitonin gene-related peptide: physiology and pathophysiology.
Review
Impact
Brain et al., London, United Kingdom. In Physiol Rev, 2014
These receptors consist of calcitonin receptor-like receptor (CLR) linked to an essential receptor activity modifying protein (RAMP) that is necessary for full functionality.
Intermedin/adrenomedullin2: an autocrine/paracrine factor in vascular homeostasis and disease.
Review
Qi et al., Beijing, China. In Sci China Life Sci, 2014
Via calcitonin receptor-like receptor/receptor activity modifying proteins, the common receptor complexes of CGRP, IMD exerts a wide range of biological effects, especially regulation of cardiovascular homeostasis.
Roles of CLR/RAMP receptor signaling in reproduction and development.
Review
Hsu et al., Taiwan. In Curr Protein Pept Sci, 2013
Recent research into their functions in reproduction has illuminated the role of these peptides and their cognate receptors (calcitonin receptor-like receptor/receptor activity-modifying protein (CLR/RAMP) receptors) in fetal-maternal blood circulation, fetoplacental development, female gamete development, and gamete movement in the oviduct.
CGRP receptor antagonism and migraine therapy.
Review
Warfvinge et al., Lund, Sweden. In Curr Protein Pept Sci, 2013
The CGRP receptor consists of a complex of calcitonin receptor-like receptor (CLR), receptor activity-modifying protein 1 (RAMP1) and receptor component protein (RCP).
Hedgehog signaling via a calcitonin receptor-like receptor can induce arterial differentiation independently of VEGF signaling in zebrafish.
GeneRIF
van Eeden et al., Sheffield, United Kingdom. In Blood, 2012
Hh is able to bypass VEGF to induce arterial differentiation in ECs via the calcitonin receptor-like receptor, thus revealing a surprising complexity in the interplay between Hh and VEGF signaling during arteriovenous specification.
Localization of calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 1 (RAMP1) in human gastrointestinal tract.
GeneRIF
Bhargava et al., San Francisco, United States. In Peptides, 2012
CLR and RAMP1 co-localize in the enteric nervous system of the stomach, ileum and colon, and are in close proximity to their ligands CGRP and IMD
Direct interactions between calcitonin-like receptor (CLR) and CGRP-receptor component protein (RCP) regulate CGRP receptor signaling.
GeneRIF
Dickerson et al., Miami, United States. In Endocrinology, 2012
CGRP-receptor component protein has been found to interact only with calcitonin-like receptor and represents a novel neuroendocrine regulatory step in calcitonin gene-related peptide signaling.
Transient expression of the calcitonin receptor by enteric neurons of the embryonic and early post-natal mouse.
GeneRIF
Furness et al., Melbourne, Australia. In Cell Tissue Res, 2012
The perinatal expression of CTR within the ENS suggests that the calcitonin/CTR system may have a role in the maturation of enteric neurons
Intermedin stabilized endothelial barrier function and attenuated ventilator-induced lung injury in mice.
GeneRIF
Witzenrath et al., Berlin, Germany. In Plos One, 2011
Data show that mechanical ventilation reduced the expression of receptor activity-modifying protein RAMP3, but not of intermedin (IMD), calcitonin receptor-like receptor (CRLR), and RAMP1 and RAMP2.
International Union of Pharmacology. LXIX. Status of the calcitonin gene-related peptide subtype 2 receptor.
Impact
International Union of Pharmacology et al., Birmingham, United Kingdom. In Pharmacol Rev, 2008
After the cloning of calcitonin receptor-like receptor (CLR) and receptor activity-modifying proteins (RAMPs), it became clear that the CGRP(1) receptor was a complex between CLR and RAMP1.
Vascular actions of calcitonin gene-related peptide and adrenomedullin.
Review
Impact
Grant et al., London, United Kingdom. In Physiol Rev, 2004
All three peptides can act on a family of CGRP receptors that consist of calcitonin receptor-like receptor (CL) linked to one of three receptor activity-modifying proteins (RAMPs) that are essential for functional activity.
RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor.
Impact
Foord et al., Stevenage, United Kingdom. In Nature, 1998
Here we show that a receptor with seven transmembrane domains, the calcitonin-receptor-like receptor (CRLR), can function as either a CGRP receptor or an adrenomedullin receptor, depending on which members of a new family of single-transmembrane-domain proteins, which we have called receptor-activity-modifying proteins or RAMPs, are expressed.
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