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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Protein phosphatase 3, catalytic subunit, beta isozyme

calcineurin Abeta, PPP3CB
Top mentioned proteins: APP, CAN, CNB, NFATC, CNA
Papers on calcineurin Abeta
MicroRNA-30 family members regulate calcium/calcineurin signaling in podocytes.
New
Liu et al., In J Clin Invest, Dec 2015
Here, we showed that critical components of calcium/calcineurin signaling, including TRPC6, PPP3CA, PPP3CB, PPP3R1, and NFATC3, are the targets of the microRNA-30 family (miR-30s).
A novel interaction between ATOH8 and PPP3CB.
New
Brand-Saberi et al., Bochum, Germany. In Histochem Cell Biol, Nov 2015
PPP3CB belongs to the catalytic subunit of the serine/threonine phosphatase, calcineurin, which can dephosphorylate its substrate proteins to regulate their physiological activities.
Cellular responses of novel human pancreatic β-cell line, 1.1B4 to hyperglycemia.
Flatt et al., Coleraine, United Kingdom. In Islets, 2013
Effects of hyperglycemia on secretory function were accompanied by decreased mRNA expression of INS, GCK, PCSK1, PCSK2, PPP3CB, GJA1, ABCC8, and KCNJ11.
[Expression profile of calcineurin pathway genes in myocardium tissues in relation to ischemic heart remodeling in humans].
Puzyrev et al., In Mol Biol (mosk), 2013
Results of quantitative expression profiling study of main calcineurin pathway genes PPP3CA, PPP3R1, PPP3CB, GATA4 and NFATC4 in myocardium of right atrium auricle of patients with a coronary heart disease, exposed to various types of surgical treatments depending on weight of a clinical finding (surgical reconstruction of the geometry of left ventricle (LV) (postinfarction aneurysm) or coronary artery bypass grafting in case of unaltered morphology of LV) are presented.
MicroRNA-384-5p regulates ischemia-induced cardioprotection by targeting phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta (PI3K p110δ).
Liu et al., Beijing, China. In Apoptosis, 2013
In addition, bioinformatics analyses, such as Gene ontology and Pathway assays, were applied to determine the apoptosis pathway, only regulated by miR-384-5p, and all the associated target genes (PIK3CD, PPP3CA, PPP3CB, PPP3R1, CASP3 and IL1A).
Pathogenesis of hypertrophic cardiomyopathy caused by myozenin 2 mutations is independent of calcineurin activity.
Marian et al., Houston, United States. In Cardiovasc Res, 2013
Likewise, lentiviral-mediated expression of the MYOZ2(I246M) did not affect RCAN1.4 and calcineurin (PPP3CB) protein levels.
Human molecular genetic and functional studies identify TRIM63, encoding Muscle RING Finger Protein 1, as a novel gene for human hypertrophic cardiomyopathy.
Marian et al., Houston, United States. In Circ Res, 2012
Expression of the mutant TRIM63 was associated with mislocalization of TRIM63 to sarcomere Z disks, impaired auto-ubiquitination, reduced ubiquitination and UPS-mediated degradation of myosin heavy chain 6, cardiac myosin binding protein C, calcineurin (PPP3CB), and p-MTOR in adult cardiac myocytes.
Calcineurin and Akt expression in hypertrophied bladder in STZ-induced diabetic rat.
GeneRIF
Daneshgari et al., Cleveland, United States. In Exp Mol Pathol, 2012
The expression levels of both the catalytic A and regulatory B subunits of calcineurin were increased at 1 and 2 weeks, but not at 9 weeks, after the induction of streptozotocin diabetes.
Profiling of differentially expressed genes using suppression subtractive hybridization in an equine model of chronic asthma.
Lussier et al., Saint-Hyacinthe, Canada. In Plos One, 2011
Genes of particular interest associated with asthmatic airway inflammation and remodeling included those related to PPP3CB/NFAT, RhoA, and LTB4/GPR44 signaling pathways.
P43-dependent mitochondrial activity regulates myoblast differentiation and slow myosin isoform expression by control of Calcineurin expression.
GeneRIF
Wrutniak-Cabello et al., Montpellier, France. In Exp Cell Res, 2011
The expression of a constitutively active Calcineurin stimulates myoblast differentiation, whereas a Calcineurin antisense has the opposite effect.
Are calcineurin genes associated with athletic status? A function, replication study.
GeneRIF
Lucia et al., Beijing, China. In Med Sci Sports Exerc, 2011
The C allele of protein phosphatase 3 subunit alpha rs3804358 polymorphism was overrepresented in athletes compared with controls, whereas the T allele of protein phosphatase 3 subunit beta rs3763679 polymorphism was underrepresented in athletes.
ANXA7, PPP3CB, DNAJC9, and ZMYND17 genes at chromosome 10q22 associated with the subgroup of schizophrenia with deficits in attention and executive function.
GeneRIF
Hwu et al., Yün-lin, Taiwan. In Biol Psychiatry, 2011
ANXA7, PPP3CB, DNAJC9, and ZMYND17 genes are potential candidate genes for schizophrenia, especially in patients with deficits in sustained attention and executive function.
Expression of a constitutively active calcineurin encoded by an intron-retaining mRNA in follicular keratinocytes.
GeneRIF
Tomizawa et al., Okayama, Japan. In Plos One, 2010
A novel-splicing variant of calcineurin Ass CnAss-FK, which is encoded by an intron-retaining mRNA and is deficient in the autoinhibitory domain, is predominantly expressed in mature follicular keratinocytes.
Long noncoding intronic RNAs are differentially expressed in primary and metastatic pancreatic cancer.
Reis et al., São Paulo, Brazil. In Mol Cancer, 2010
Differential expression of a subset of intronic lncRNAs (PPP3CB, MAP3K14 and DAPK1 loci) in metastatic samples was confirmed by Real-Time PCR.
Polymorphisms in the calcineurin genes are associated with the training responsiveness of cardiac phenotypes in Chinese young adults.
Lucia et al., Beijing, China. In Eur J Appl Physiol, 2010
We studied the association of 55 polymorphisms in the PPP3CA, PPP3CB, PPP3CC, PPP3R1 and PPP3R2 genes with both (1) the pre-training levels and (2) responsiveness to endurance training (18 weeks), of echocardiographic variables.
Transcriptional upregulation of calcineurin Abeta by endothelin-1 is partially mediated by calcium/calmodulin-dependent protein kinase IIdelta3 in rat cardiomyocytes.
Fukunaga et al., Sendai, Japan. In Biochim Biophys Acta, 2010
Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and calcineurin (CaN) are positive regulators of cardiac hypertrophy, but the nature of cross-talk between CaMKII and CaN signaling pathways in hypertrophic cardiomyocytes remains unclear.
Reciprocal repression between microRNA-133 and calcineurin regulates cardiac hypertrophy: a novel mechanism for progressive cardiac hypertrophy.
Yang et al., Harbin, China. In Hypertension, 2010
Moreover, the antisense oligodeoxynucleotides against the catalytic subunits of calcineurin Abeta and the decoy oligodeoxynucleotides targeting nuclear factor of activated T cells transcription factor, a calcineurin downstream effector, increased miR-133 expression in cultured primary cardiomyocytes.
Inhibition of the calcineurin-NFAT signalling cascade in the treatment of heart failure.
Review
GeneRIF
Ritter et al., Würzburg, Germany. In Recent Pat Cardiovasc Drug Discov, 2009
[review] The nuclear localization sequence, a region spanning amino acids 172-183 of calcineurin A beta, is essential for recognition and shuttling of calcineurin into the nucleus by importin beta.
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