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Filamin binding LIM protein 1

Cal, S100A11
This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple C-terminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. This protein may be involved in the assembly and stabilization of actin-filaments and likely plays a role in modulating cell adhesion, cell morphology and cell motility. This protein also localizes to the nucleus and may affect cardiomyocyte differentiation after binding with the CSX/NKX2-5 transcription factor. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Papers using Cal antibodies
Elevation of human α-defensins and S100 calcium binding protein A8 and A9 in tear fluid of pterygium patients.
Tong Louis et al., In Molecular Vision, 2008
... Mouse monoclonal antibodies against S100A4, S100A6, S100A9, and S100A11 were purchased from Abnova (Taipei, Taiwan), and mouse ...
A novel LIM protein Cal promotes cardiac differentiation by association with CSX/NKX2-5
Komuro Issei et al., In The Journal of Cell Biology, 1998
... Molecular cloning of CalWe performed a yeast two-hybrid screening using the MATCHMAKER Two-Hybrid System (CLONTECH Laboratories, Inc.) as described ...
Protein measurement with the Folin phenol reagent.
Hartl Dominik, In PLoS ONE, 1950
... Monoclonal anti-Cal-1 (9A4H8D3, ab3589) and polyclonal anti-Cal-2 (2539) were purchased from abcam and Cell Signaling, respectively ...
Papers on Cal
Critical role of filamin-binding LIM protein 1 (FBLP-1)/migfilin in regulation of bone remodeling.
Wu et al., Pittsburgh, United States. In J Biol Chem, 2012
results identify FBLP-1 as a key regulator of bone homeostasis and suggest that FBLP-1 functions in this process through modulating both the intrinsic properties of OB/BMSCs (i.e., BMSC-extracellular matrix adhesion and migration
Filamin a regulates neural progenitor proliferation and cortical size through Wee1-dependent Cdk1 phosphorylation.
Sheen et al., Boston, United States. In J Neurosci, 2012
This study demonistrated that a molecular mechanism whereby FlnA loss impaired G2 to M phase entry, leading to cell cycle prolongation, compromised neural progenitor proliferation, and reduced brain size.
Involvement of S100A14 protein in cell invasion by affecting expression and function of matrix metalloproteinase (MMP)-2 via p53-dependent transcriptional regulation.
Liu et al., Beijing, China. In J Biol Chem, 2012
that S100A14 promotes cell motility and invasiveness by regulating the expression and function of MMP2 in a p53-dependent manner.
Migfilin regulates esophageal cancer cell motility through promoting GSK-3β-mediated degradation of β-catenin.
Liu et al., Beijing, China. In Mol Cancer Res, 2012
Migfilin promoted beta-catenin degradation by reinforcing the association between beta-catenin and GSK-3beta.
The gene expression analysis of blood reveals S100A11 and AQP9 as potential biomarkers of infective endocarditis.
Mege et al., Marseille, France. In Plos One, 2011
Using transcriptional signatures of blood samples,identified S100A11 as a potential diagnostic marker of infective endocarditis, and AQP9 as a potential prognostic factor.
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