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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

S100 calcium binding protein A8

CagA, SUR1, Calgranulin A, S100A8, MRP8
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Calgranulin B, CAN, HAD, V1a, AGE
Papers using CagA antibodies
Elevation of human α-defensins and S100 calcium binding protein A8 and A9 in tear fluid of pterygium patients.
Supplier
Tong Louis et al., In Molecular Vision, 2008
... S100A6, S100A9, and S100A11 were purchased from Abnova (Taipei, Taiwan), and mouse monoclonal antibody against S100A8 from Acris Antibodies (Hiddenhausen, Germany) was ...
Papers on CagA
Molecular mechanisms of gastric cancer initiation and progression by Helicobacter pylori.
New
Merrell et al., Bethesda, United States. In Curr Opin Infect Dis, Feb 2016
In addition to utilizing the oncogenic CagA toxin to alter host cell signaling pathways, H. pylori also induces host DNA damage and alters DNA methylation to perturb downstream signaling.
Calprotectin (S100A8/A9) and S100A12 are associated with measures of disease activity in a longitudinal study of patients with rheumatoid arthritis treated with infliximab.
New
Halse et al., Bergen, Norway. In Scand J Rheumatol, Feb 2016
OBJECTIVES: The pro-inflammatory proteins calprotectin (a heterocomplex of S100A8/A9) and S100A12 have been associated with disease activity in rheumatoid arthritis (RA).
Osteoarthritis year in review 2015: biology.
Review
New
Malfait, Chicago, United States. In Osteoarthritis Cartilage, Jan 2016
Highlights include a homeostatic role for CXC chemokines in cartilage, identification of the zinc-ZIP8-MTF1 axis as an essential regulator of cartilage catabolism, and the discovery that a small aggrecan fragment can have catabolic and pro-inflammatory effects through Toll-like receptor 2. Synovitis can promote joint damage, partly through alarmins such as S100A8.
The Nucleotide-Binding Sites of SUR1: A Mechanistic Model.
Review
New
Puljung et al., Oxford, United Kingdom. In Biophys J, Jan 2016
ATP-sensitive potassium (KATP) channels comprise four pore-forming Kir6.2 subunits and four modulatory sulfonylurea receptor (SUR) subunits.
Beyond Cholesterol - New Cardiovascular Biomarkers.
New
Mangge, In Nestle Nutr Inst Workshop Ser, Dec 2015
New biomarkers in these mechanisms include pentraxin 3, calprotectins S100A8/S100A9, myeloperoxidase, adiponectin, interleukins, and chemokines.
Helicobacter pylori strains harboring babA2 from Indian sub population are associated with increased virulence in ex vivo study.
New
Mukhopadhyay et al., Calcutta, India. In Gut Pathog, Dec 2015
BACKGROUND: The babA2 gene along with the cagA and vacA of Helicobacter pylori has been considered as a risk factor for the disease outcome in certain populations.
S100A12 and the S100/Calgranulins: Emerging Biomarkers for Atherosclerosis and Possibly Therapeutic Targets.
Review
New
Hofmann Bowman et al., Chicago, United States. In Arterioscler Thromb Vasc Biol, Dec 2015
This review focuses on S100/calgranulin proteins (S100A8, S100A9, and S100A12) and their receptor RAGE in mediating vascular inflammation.
Correlation between myeloid-derived suppressor cells and S100A8/A9 in tumor and autoimmune diseases.
Review
New
Chen et al., Shantou, China. In Int Immunopharmacol, Dec 2015
Two calcium-binding proteins S100A8 and S100A9 act as important mediators in acute and chronic inflammation.
Modelling human development and disease in pluripotent stem-cell-derived gastric organoids.
Impact
Wells et al., Cincinnati, United States. In Nature, 2015
Using hGOs to model pathogenesis of human disease, we found that H. pylori infection resulted in rapid association of the virulence factor CagA with the c-Met receptor, activation of signalling and induction of epithelial proliferation.
Hypertension in Type 2 Diabetes Mellitus: Do We Need to Redefine the Role of Sulfonylureas?
Sehra et al., New Delhi, India. In Recent Pat Cardiovasc Drug Discov, 2014
RESULTS: Sulfonylureas due to their action on SUR1 in pituitary gland may release growth hormone and anti-diuretic hormone; action on SUR2B acting upon smooth muscle may interfere with vasodilatation, thereby causing hypertension.
Target-selective protein S-nitrosylation by sequence motif recognition.
Impact
Fox et al., Cleveland, United States. In Cell, 2014
Here, we describe a stimulus-inducible, heterotrimeric S-nitrosylase complex consisting of inducible NOS (iNOS), S100A8, and S100A9.
Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity.
Impact
Murphy et al., New York City, United States. In Cell Metab, 2014
Adipose S100A8/A9 induced ATM TLR4/MyD88 and NLRP3 inflammasome-dependent IL-1β production.
Obesity corrupts myelopoiesis.
Impact
Murray, Memphis, United States. In Cell Metab, 2014
(2014) show that adipose cells locally activate IL-1β in macrophages in part through the alarmin S100A8/A9, which stimulates bone marrow myelopoiesis to perpetuate nonresolving inflammation.
S100A8-S100A9 protein complex mediates psoriasis by regulating the expression of complement factor C3.
Impact
Wagner et al., Madrid, Spain. In Immunity, 2014
Here we performed proteomic analyses of human psoriatic epidermis and found S100A8-S100A9, also called calprotectin, as the most upregulated proteins, followed by the complement component C3.
Biomarkers in Exhaled Breath Condensate and Serum of Chronic Obstructive Pulmonary Disease and Non-Small-Cell Lung Cancer.
Review
Thomas et al., Sydney, Australia. In Int J Chronic Dis, 2012
In the serum, S100A8, S100A9, and S100A12 of the S100 proteins are proinflammatory markers.
S100A8 and S100A9 are messengers in the crosstalk between epidermis and dermis modulating a psoriatic milieu in human skin.
GeneRIF
Lee et al., Taejŏn, South Korea. In Biochem Biophys Res Commun, 2012
the upregulated production of S100A8 and S100A9 by psoriatic epidermal keratinocytes activated adjacent keratinocytes to produce several cytokines.
Oncogenic Kras expression in postmitotic neurons leads to S100A8-S100A9 protein overexpression and gliosis.
GeneRIF
Zhang et al., Madison, United States. In J Biol Chem, 2012
Our results identify overexpression of S100A8-S100A9 in neurons as an early step in oncogenic Kras-induced gliosis.
The role of myofibroblasts in upregulation of S100A8 and S100A9 and the differentiation of myeloid cells in the colorectal cancer microenvironment.
GeneRIF
Kim et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2012
The upregulation of S100A8/A9 in tumor-infiltrated myeloid cells could be triggered by IL-6 and IL-8 released from myofibroblasts.
Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis.
GeneRIF
Iovanna et al., Marseille, France. In J Clin Invest, 2012
a NUPR1/RELB/IER3 stress-related pathway that is required for oncogenic Kras(G12D)-dependent transformation of the pancreas.
Variant of Helicobacter pylori CagA proteins induce different magnitude of morphological changes in gastric epithelial cells.
GeneRIF
Ramelah et al., Kuala Lumpur, Malaysia. In Malays J Pathol, 2012
Variant of Helicobacter pylori CagA proteins induce different magnitude of morphological changes in gastric epithelial cells.
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