Osteoarthritis year in review 2015: biology.
Chicago, United States. In Osteoarthritis Cartilage, Jan 2016
Highlights include a homeostatic role for CXC chemokines in cartilage, identification of the zinc-ZIP8-MTF1 axis as an essential regulator of cartilage catabolism, and the discovery that a small aggrecan fragment can have catabolic and pro-inflammatory effects through Toll-like receptor 2. Synovitis can promote joint damage, partly through alarmins such as S100A8.
Obesity corrupts myelopoiesis.
Memphis, United States. In Cell Metab, 2014
(2014) show that adipose cells locally activate IL-1β in macrophages in part through the alarmin S100A8/A9, which stimulates bone marrow myelopoiesis to perpetuate nonresolving inflammation.