gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Cadherin 20

cadherin-7, CDH7, CDH20, cadherin20
This gene is a type II classical cadherin from the cadherin superfamily. The encoded membrane protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Cadherins mediate cell-cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types and the maintenance of orderly structures. Alternative splicing in the 5' UTR of this gene yields variant transcripts encoding the same protein. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: R-cadherin, N-cadherin, TUBE, CAN, CDH19
Papers on cadherin-7
Pax3 and Pax7 interact reciprocally and regulate the expression of cadherin-7 through inducing neuron differentiation in the developing chicken spinal cord.
Redies et al., Jena, Germany. In J Comp Neurol, Sep 2015
Overexpression of Pax3 and Pax7 represses the endogenous expression of cadherin-7, a member of the cadherin family of morphogenetic genes, and induces its ectopic expression.
Next-Generation Sequencing of Pulmonary Sarcomatoid Carcinoma Reveals High Frequency of Actionable MET Gene Mutations.
Borczuk et al., Guangzhou, China. In J Clin Oncol, Aug 2015
RESULTS: In addition to confirming mutations in known cancer-associated genes (TP53, KRAS, PIK3CA, MET, NOTCH, STK11, and RB1), several novel mutations in additional genes, including RASA1, CDH4, CDH7, LAMB4, SCAF1, and LMTK2, were identified and validated.
Cadherin-7 regulates mossy fiber connectivity in the cerebellum.
Okano et al., Tokyo, Japan. In Cell Rep, 2014
Here, we demonstrate that cadherin-7 (Cdh7) plays a dual role in axonal growth termination and specific synapse formation during the development of the cerebellar mossy fiber circuit.
Common variants in the CDH7 gene are associated with major depressive disorder in the Han Chinese population.
Shi et al., Shanghai, China. In Behav Genet, 2014
Cadherin-7 (CDH7) gene encodes a calcium dependent cell-cell adhesion glycoprotein.
Recurrent pre-existing and acquired DNA copy number alterations, including focal TERT gains, in neuroblastoma central nervous system metastases.
Cheung et al., New York City, United States. In Genes Chromosomes Cancer, 2013
Based on minimal common regions, gene expression, and biological properties, TERT (5p), NR2F2 (15q), ALDH1A3 (15q), CDKN2A (9p), and possibly CDH7 and CDH19 (18q) were candidate genes associated with the CNS metastatic process.
Genetic factors in nonsmokers with age-related macular degeneration revealed through genome-wide gene-environment interaction analysis.
Pericak-Vance et al., Philadelphia, United States. In Ann Hum Genet, 2013
Analyses stratified by smoking found genetic associations largely restricted to nonsmokers, with one notable exception: the chromosome 18q22.1 intergenic SNP rs17073641 (between SERPINB8 and CDH7), more strongly associated in nonsmokers (OR = 0.57, P = 2.73 × 10(-5) ), with an inverse association among smokers (OR = 1.42, P = 0.00228), suggesting that smoking modifies the effect of some genetic polymorphisms on AMD risk.
MicroRNA-375, a new regulator of cadherin-7, suppresses the migration of chondrogenic progenitors.
Jin et al., Iksan, South Korea. In Cell Signal, 2013
Blockade of miR-375 via peptide nucleic acid (PNA)-based antisense oligonucleotides (ASOs) increased the migration of chondrogenic progenitors, the formation of precartilage condensations and the expression level of cadherin-7.
8q12 microduplication including CHD7: clinical report on a new patient with Duane retraction syndrome type 3.
Bonaglia et al., Monza, Italy. In Mol Cytogenet, 2012
BACKGROUND: A novel multiple congenital anomalies syndrome has been recently identified in four patients carrying a 8q12 microduplication sharing the smallest region of overlap (SRO, size 1.6 Mb) including five genes CA8, ASPH, RAB2B, CLVS1 and CDH7.
Exome capture sequencing of adenoma reveals genetic alterations in multiple cellular pathways at the early stage of colorectal tumorigenesis.
Zheng et al., Hangzhou, China. In Plos One, 2012
Most of these mutations including OR6X1, SLC15A3, KRTHB4, RBFOX1, LAMA3, CDH20, BIRC6, NMBR, GLCCI1, EFR3A, and FTHL17 were newly reported in colorectal adenomas.
Homozygous deletions of cadherin genes in chondrosarcoma-an array comparative genomic hybridization study.
Knuutila et al., Helsinki, Finland. In Cancer Genet, 2012
Deletions were also found to affect genes of the cadherin family, including CDH4 and CDH7, each of which had a targeted homozygous loss in one case, and CDH19, which had a targeted homozygous loss in two cases.
Cadherins and neuropsychiatric disorders.
Hübner et al., Jena, Germany. In Brain Res, 2012
For example, CDH15 and PCDH19 are associated with cognitive impairment; CDH5, CDH8, CDH9, CDH10, CDH13, CDH15, PCDH10, PCDH19 and PCDHb4 with autism; CDH7, CDH12, CDH18, PCDH12 and FAT with bipolar disease and schizophrenia; and CDH11, CDH12 and CDH13 with methamphetamine and alcohol dependency.
Catenin-dependent cadherin function drives divisional segregation of spinal motor neurons.
Price et al., London, United Kingdom. In J Neurosci, 2012
Additionally, reduction of the expression of cadherin-7, a cadherin predominantly expressed in motor neurons only during their migration, also perturbs divisional segregation.
CHD7 mutations and CHARGE syndrome: the clinical implications of an expanding phenotype.
van Ravenswaaij-Arts et al., Groningen, Netherlands. In J Med Genet, 2011
CHD7 mutations and CHARGE syndrome (Review)
Dynamic expression of cadherins regulates vocal development in a songbird.
Okanoya et al., Wako, Japan. In Plos One, 2010
Previously, we found that type-II cadherin expressions are switched in the robust nucleus of arcopallium from cadherin-7-positive to cadherin-6B-positive during the phase from sensory to sensorimotor learning stage in a songbird, the Bengalese finch.
Cadherin-7 interacts with melanoma inhibitory activity protein and negatively modulates melanoma cell migration.
Bosserhoff et al., Regensburg, Germany. In Cancer Sci, 2009
Cadherin-7 interacts with melanoma inhibitory activity protein and negatively modulates melanoma cell migration.
Cadherin-7 function in zebrafish development.
Wilson et al., Akron, United States. In Cell Tissue Res, 2008
cadherin-7 plays an important role in the normal development of the zebrafish notochord.
Expression study of cadherin7 and cadherin20 in the embryonic and adult rat central nervous system.
Osumi et al., Sendai, Japan. In Bmc Dev Biol, 2007
Expression of cad7 and cad20 demarcates the compartments, boundaries, progenitor domains, specific nuclei and specific neural circuits during mammalian brain development.
Cloning and expression analysis of cadherin7 in the central nervous system of the embryonic zebrafish.
Liu et al., Akron, United States. In Gene Expr Patterns, 2007
cloning and spatial and temporal regulation in embryonic CNS
Genome duplications of early vertebrates as a possible chronicle of the evolutionary history of the neural crest.
Makabe et al., Tsukuba, Japan. In Int J Biol Sci, 2005
By contrast, the epithelial-mesenchymal transition of neural crest cells is controlled by genes that evolved after the genome duplications, such as cadherin6, cadherin7, cadherin11, and rhoB.
Patch/matrix patterns of gray matter differentiation in the telencephalon of chicken and mouse.
Puelles et al., Essen, Germany. In Brain Res Bull, 2002
In the avian neostriatum, cadherin-7-positive cell clusters ("islands") are surrounded by a matrix of cells that express R-cadherin.
share on facebooktweetadd +1mail to friends