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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Cadherin 6, type 2, K-cadherin

cadherin-6, CDH6, K-cadherin, cad6
This gene encodes a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. The encoded protein is a type II cadherin and may play a role in kidney development as well as endometrium and placenta formation. Decreased expression of this gene may be associated with tumor growth and metastasis. [provided by RefSeq, May 2011] (from NCBI)
Top mentioned proteins: E-cadherin, cadherin-11, CAN, N-cadherin, XRCC1
Papers using cadherin-6 antibodies
Plakoglobin and β-catenin: protein interactions, regulation and biological roles
Rossini G P et al., In British Journal of Cancer, 1999
... The anti-K-cadherin antibody was purchased from Santa Cruz Biotechnology.
Papers on cadherin-6
Molecular features distinguish ten neuronal types in the mouse superficial superior colliculus.
Kim et al., New Haven, United States. In J Comp Neurol, Jan 2016
Our analysis revealed 12 molecules with distinct expression patterns in mouse sSC: cadherin 7, contactin 3, netrin G2, cadherin 6, protocadherin 20, retinoid-related orphan receptor β, brain-specific homeobox/POU domain protein 3b, Ets variant gene 1, substance P, somatostatin, vasoactive intestinal polypeptide and parvalbumin.
Classic cadherin expressions balance postnatal neuronal positioning and dendrite dynamics to elaborate the specific cytoarchitecture of the mouse cortical area.
Inoue et al., Kodaira, Japan. In Neurosci Res, Nov 2015
Here we map expression profiles of classic cadherins in the postnatal mouse barrel field of the primary somatosensory area (S1BF) and generate a novel bacterial artificial chromosome transgenic (BAC-Tg) mouse line selectively illuminating nuclei of cadherin-6 (Cdh6)-expressing layer IV barrel neurons to confirm that tangential cellular assemblage of S1BF is established by postnatal day 5 (P5).
Concomitant high expression of BRAFV600E, P-cadherin and cadherin 6 is associated with High TNM stage and lymph node metastasis in conventional papillary thyroid carcinoma.
Liu et al., Chongqing, China. In Clin Endocrinol (oxf), Sep 2015
P-cadherin and cadherin 6 have been shown to be mesenchymal-associated cadherins and promote cancer cell invasion and metastasis.
Differential expression of protocadherin-19, protocadherin-17, and cadherin-6 in adult zebrafish brain.
Sochacka-Marlowe et al., Akron, United States. In J Comp Neurol, Jul 2015
In this study we used in situ hybridization to examine mRNA expression of three cadherins, protocadherin-19, protocadherin-17, and cadherin-6 in adult zebrafish brain.
Homozygous NOTCH3 null mutation and impaired NOTCH3 signaling in recessive early-onset arteriopathy and cavitating leukoencephalopathy.
Seri et al., Bologna, Italy. In Embo Mol Med, Jun 2015
NOTCH3 targets acting in the regulation of arterial tone (KCNA5) or expressed in the vasculature (CDH6) were downregulated.
Involvement of orphan nuclear receptor COUP-TFII in cadherin-6 and cadherin-11 regulation: implications in development and cancer.
Giroldi et al., Villeurbanne, France. In Mech Dev, May 2015
Kidney development is characterized by a mesenchymal-epithelial transition underlain by a cadherin-11 to cadherin-6 switch, the regulation mechanisms of which are presently unexplained.
Whole exome sequencing in females with autism implicates novel and candidate genes.
Manzardo et al., Kansas City, United States. In Int J Mol Sci, 2014
Five females presented with functional variants of X-linked genes (IL1RAPL1, PIR, GABRQ, GPRASP2, SYTL4) with cadherin, protocadherin and ankyrin repeat gene families most commonly altered (e.g., CDH6, FAT2, PCDH8, CTNNA3, ANKRD11).
Epithelial DLD-1 Cells with Disrupted E-cadherin Gene Retain the Ability to Form Cell Junctions and Apico-basal Polarity.
T Suzuki et al., In Cell Struct Funct, 2014
Double-knockout MDCK cells for the E-cadherin and cadherin-6 genes showed similar results, suggesting that the above properties were general.
Cadherin 6 has a functional role in platelet aggregation and thrombus formation.
Kenny et al., Dublin, Ireland. In Arterioscler Thromb Vasc Biol, 2012
role of cadherin 6 as a novel ligand for alpha(IIb)beta(3) and highlights its function in thrombus formation.
PP065. dNK and dNK-CM mediated alterations of DNA methylation in extravillous cytotrophoblasts (EVTS).
Robinson et al., Vancouver, Canada. In Pregnancy Hypertens, 2012
dNK-CM but not dNK reduced methylation of ITGAD and PCDH8 (protocadherin 8) and increased methylation of CDH4 and CDH6.
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
Kooner et al., London, United Kingdom. In Nat Genet, 2011
We identified 69 candidate genes, including genes involved in biliary transport (ATP8B1 and ABCB11), glucose, carbohydrate and lipid metabolism (FADS1, FADS2, GCKR, JMJD1C, HNF1A, MLXIPL, PNPLA3, PPP1R3B, SLC2A2 and TRIB1), glycoprotein biosynthesis and cell surface glycobiology (ABO, ASGR1, FUT2, GPLD1 and ST3GAL4), inflammation and immunity (CD276, CDH6, GCKR, HNF1A, HPR, ITGA1, RORA and STAT4) and glutathione metabolism (GSTT1, GSTT2 and GGT), as well as several genes of uncertain or unknown function (including ABHD12, EFHD1, EFNA1, EPHA2, MICAL3 and ZNF827).
Cadherin-6 mediates axon-target matching in a non-image-forming visual circuit.
Huberman et al., San Diego, United States. In Neuron, 2011
Data show that during development, the adhesion molecule cadherin-6 is expressed by a subset of retinal ganglion cells and also by their targets in the brain.
Cell adhesion molecule cadherin-6 function in zebrafish cranial and lateral line ganglia development.
Marrs et al., Akron, United States. In Dev Dyn, 2011
Data illustrate an important role for cdh6 in the formation of cranial ganglia and their nerves.
Polycomb target genes are silenced in multiple myeloma.
Jernberg-Wiklund et al., Uppsala, Sweden. In Plos One, 2009
The chromatin modifications were determined at five PRC2 targets commonly underexpressed in multiple myeloma (CIITA, CXCL12, GATA2, CDH6 and ICSBP/IRF8). The selected genes were confirmed to be underexpressed in MM compared to normal plasma cells.
Genetic labeling of mouse rhombomeres by Cadherin-6::EGFP-BAC transgenesis underscores the role of cadherins in hindbrain compartmentalization.
Inoue et al., Kodaira, Japan. In Neurosci Res, 2009
These results suggest the role of Cdh6 in coordinating mouse hindbrain compartments possibly under the control of Hox gene regulatory network.
[Molecular and cytometric analysis of renal cell carcinoma cells. Concepts, techniques and prospects].
Tostain et al., Saint-Étienne, France. In Prog Urol, 2003
Some of the antigens used for molecular diagnosis of clear cell RCC, such as cadherin-6, are present in the normal kidney, while others are newly formed antigens (TuM2PK, MN/CA9, CA12, calpain) or ectopic (PSMA, PSA, KLKI, cytokeratin 7 vimentin) or induce abnormal glycosylation (sialyl Lewis'X, galectins) indicating the malignant nature of the cells.
The role of adjuvant immunotherapy in renal cell carcinoma.
De Mulder et al., Nijmegen, Netherlands. In Curr Urol Rep, 2002
Other molecular markers, such as cadherin-6 and G250 antigen, may become important.
Classical cadherins in urological cancers.
Bringuier et al., Nijmegen, Netherlands. In Morphologie, 2000
In proximal kidney tubule and in its derived tumours cadherin-6 seems to take over E-cadherin function.
Cadherins in renal cell carcinoma.
Heicappell, Berlin, Germany. In Anticancer Res, 1999
Four major cadherins have been demonstrated in normal kidney and renal cell carcinoma: N-cadherin, E-cadherin, ksp-cadherin, and cadherin 6.
[Recent progress of prognostic factors in renal cell carcinoma].
Shimazui, Tsukuba, Japan. In Gan To Kagaku Ryoho, 1998
Recent studies have shown that nuclear morphometry, cell proliferation analyses, (Ki-67 and AgNOR), expression of cell adhesion molecule, (cadherin-6 and alpha-catenin), and protease expression, expression and serum level of growth factors (VEGF and bFGF), might be among the new candidates for a useful prognostic marker.
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