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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Cadherin 11

cadherin-11, OB-cadherin, CDH11, cad11
This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: N-cadherin, CAN, E-cadherin, V1a, Actin
Papers using cadherin-11 antibodies
Rapid and simple comparison of messenger RNA levels using real-time PCR.
Supplier
Klefstrom Juha, In PLoS ONE, 2005
... were obtained from Sigma-Aldrich (Germany), meBIO (361556) and BIO (361550) from Calbiochem (San Diego, CA), anti-cadherin-11 (5B2H5) from Invitrogen (32-1700, Carlsbad, CA), anti-β-catenin antibody from BD Biosciences (610154, San Jose, CA), ...
Papers on cadherin-11
High-definition CpG methylation of novel genes in gastric carcinogenesis identified by next-generation sequencing.
New
Sepulveda et al., New York City, United States. In Mod Pathol, Feb 2016
Overall, 13 genes had significantly increased CpG methylation in gastric cancer vs non-metaplastic mucosa (BRINP1, CDH11, CHFR, EPHA5, EPHA7, FGF2, FLI1, GALR1, HS3ST2, PDGFRA, SEZ6L, SGCE, and SNRPN).
Trend of Cadherin-11 expression and its impact on cartilage degradation in the temporomandibular joints of guinea pigs with spontaneous osteoarthritis.
New
Zhou et al., Hangzhou, China. In J Oral Pathol Med, Jan 2016
BACKGROUND: This study aims to investigate spatial and temporal changes in cadherin-11 (CAD-11) expression and their effects on cartilage degeneration in the temporomandibular joint (TMJ) of guinea pigs with spontaneous osteoarthritis (OA).
miR-27b is upregulated in cervical carcinogenesis and promotes cell growth and invasion by regulating CDH11 and epithelial-mesenchymal transition.
New
Guo et al., Shenyang, China. In Oncol Rep, Jan 2016
In the present study, we observed that miR-27b was significantly increased in cervical cancer cells and tissues, and upregulation of miR-27b was negatively associated with its direct target, cadherin 11 (CDH11).
Cadherin-11 endocytosis through binding to clathrin promotes cadherin-11-mediated migration in prostate cancer cells.
New
Lin et al., Houston, United States. In J Cell Sci, Jan 2016
Cadherin-11 (Cad11) cell adhesion molecule plays a role in prostate cancer cell migration.
Cadherin 11 Involved in Basement Membrane Damage and Dermal Changes in Melasma.
New
Lee et al., South Korea. In Acta Derm Venereol, Jan 2016
Cadherin 11 (CDH11), which is upregulated in some melasma patients, has previously been shown to stimulate melanogenesis.
Tasquinimod inhibits prostate cancer growth in bone through alterations in the bone microenvironment.
New
Welén et al., Göteborg, Sweden. In Prostate, Jan 2016
Tasquinimod treatment also affected expression of factors involved in the pre-metastatic niche in the bone microenvironment (Lox, Cdh2, Cdh11, and Cxcl12).
Cell-cell and cell-matrix adhesion in survival and metastasis: Stat3 versus Akt.
New
Raptis et al., In Biomol Concepts, Jan 2016
While the epithelial (E)-cadherin is required for cells to remain tightly associated within differentiated epithelial tissues, cadherin-11 promotes invasion and metastasis, preferentially to the bone.
Cadherin-11 mRNA and protein expression in ovarian tumors of different malignancy: No evidence of oncogenic or tumor-suppressive function.
New
Milde-Langosch et al., Hamburg, Germany. In Mol Clin Oncol, Sep 2015
UNASSIGNED: Cadherin-11 (CDH11, OB-cadherin) is a mesenchymal cadherin found to be upregulated in various types of tumors and implicated in tumor progression and metastasis.
Aberrant methylation of CDH11 predicts a poor outcome for patients with bladder cancer.
New
Ma et al., Xuzhou, China. In Oncol Lett, Aug 2015
For example, hypermethylation of the promoter region of cadherin 11 (CDH11), a novel tumor suppressor gene, frequently occurs in human cancer.
CDH2 and CDH11 act as regulators of stem cell fate decisions.
Review
New
Andreadis et al., New York City, United States. In Stem Cell Res, May 2015
In this review, we focus on the role of cadherin mediated signaling in development and stem cell differentiation, with emphasis on two well-known cadherins, cadherin-2 (CDH2) (N-cadherin) and cadherin-11 (CDH11) (OB-cadherin).
Cadherin-mediated cell-cell adhesion and signaling in the skeleton.
Review
Civitelli et al., Paris, France. In Calcif Tissue Int, 2014
Partially overlapping, yet distinct roles of N-cadherin (cadherin-2) and cadherin-11 in the skeletal system have emerged from mouse genetics and in vitro studies.
Integrins and cadherins as therapeutic targets in fibrosis.
Review
Agarwal, Houston, United States. In Front Pharmacol, 2013
Adhesion molecules, in particular αvβ6 and α3β1 integrins and cadherin-11, have been demonstrated to be important mediators of tissue fibrosis.
Role of cadherin-11 in synovial joint formation and rheumatoid arthritis pathology.
Review
Dong et al., Chongqing, China. In Mod Rheumatol, 2013
Cadherin-11 is a classic cadherin adhesion molecule that mediates homophilic cell-to-cell adhesion.
Cadherins and neuropsychiatric disorders.
Review
Hübner et al., Jena, Germany. In Brain Res, 2012
For example, CDH15 and PCDH19 are associated with cognitive impairment; CDH5, CDH8, CDH9, CDH10, CDH13, CDH15, PCDH10, PCDH19 and PCDHb4 with autism; CDH7, CDH12, CDH18, PCDH12 and FAT with bipolar disease and schizophrenia; and CDH11, CDH12 and CDH13 with methamphetamine and alcohol dependency.
The human cadherin 11 is a pro-apoptotic tumor suppressor modulating cell stemness through Wnt/β-catenin signaling and silenced in common carcinomas.
GeneRIF
Tao et al., Hong Kong, Hong Kong. In Oncogene, 2012
Data indicate that CDH11 as a functional tumor suppressor and an important antagonist of Wnt/beta-catenin signaling, with frequent epigenetic inactivation in common carcinomas.
Zebrafish cadherin-11 participates in retinal differentiation and retinotectal axon projection during visual system development.
GeneRIF
Marrs et al., Indianapolis, United States. In Dev Dyn, 2012
Cdh11 expression in the developing visual system and Cdh11 loss-of-function phenotype illustrates the critical role for differential cadherin activity in visual system differentiation and organization.
Cadherin-11, a marker of the mesenchymal phenotype, regulates glioblastoma cell migration and survival in vivo.
GeneRIF
Brady-Kalnay et al., Cleveland, United States. In Mol Cancer Res, 2012
These results show the functional significance of cadherin-11 expression in glioblastoma multiforme.
Cadherin-11 contributes to pulmonary fibrosis: potential role in TGF-β production and epithelial to mesenchymal transition.
GeneRIF
Agarwal et al., Houston, United States. In Faseb J, 2012
CDH11 expression was assessed in lung tissue from idiopathic pulmonary fibrosis patients.
IL-17 increases cadherin-11 expression in a model of autoimmune experimental arthritis and in rheumatoid arthritis.
GeneRIF
Kim et al., Pusan, South Korea. In Immunol Lett, 2011
increased expression in patients with rheumatoid arthritis
Cadherin-11 in synovial lining formation and pathology in arthritis.
Impact
GeneRIF
Brenner et al., Boston, United States. In Science, 2007
synovial cadherin-11 determines the behavior of synovial cells in their proinflammatory and destructive tissue response in inflammatory arthritis
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