The lung-specific proteome defined by integration of transcriptomics and antibody-based profiling.
Uppsala, Sweden. In Faseb J, 2014
Transcript levels of 10 genes (SFTPB, SFTPC, SFTPD, SLC34A2, LAMP3, CACNA2D2, AGER, EMP2, NKX2-1, and NAPSA) were significantly associated with survival in the adenocarcinoma subgroup, thus qualifying as promising biomarker candidates.
A review of the role of genetic testing in pain medicine.
Indianapolis, United States. In Pain Physician, 2014
METHODS: This article discusses the specific pain implications of genetic variations in CYP1A2, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4, CYP3A7, OPRM1, OPRK1, OPRD1, COMT, GABA, UGT, MC1R, GCH1, ABCB1, P-glycoprotein, 5HTR1A, 5HTR2A, MTHFR, CACNA2D2, and 5-HTTLPR.
Validation and target gene screening of hsa-miR-205 in lung squamous cell carcinoma.
Shanghai, China. In Chin Med J (engl), 2013
Ten target genes (ACSL1, AXIN2, CACNA2D2, FOXO3, PPP1R3A, PRKAG3, RUNX1, SMAD4, STK3 and TBL1XR1) were significantly down-regulated in SQ and had a strong negative correlation with miR-205, while one target gene (CDH3) was up-regulated in SQ and exhibited a strong positive correlation with miR-205.
Cerebellar ataxia, seizures, premature death, and cardiac abnormalities in mice with targeted disruption of the Cacna2d2 gene.
Frederick, United States. In Am J Pathol, 2004
In mice, targeted disruption of Cacna2d2 led to growth retardation, reduced life span, ataxia, enhanced susceptibility to seizures, and cardiac abnormalities. Cacna2d2 may be involved in hereditary cerebellar ataxias and epileptic disorders in humans.
A reexamination of the diploidlike meiotic behavior of polyploid cotton.
Tucson, United States. In Theor Appl Genet, 1976
Chromosome associations at pachytene, diakinesis, and metaphase I were analyzed in haploids of the allotetraploid G.hirsutwn, in the F1 hybrid between G.arboreum (A2) and G. raimondii (D5), and in the doubled hybrid 2(A2D2) in an effort to define more clearly the mechanism responsible for the diploidlike behavior of the natural allotetraploids.