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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Calcium channel, voltage-dependent, T type, alpha 1G subunit

CACNA1G, Cav3.1
Voltage-sensitive calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death. This gene encodes a T-type, low-voltage activated calcium channel. The T-type channels generate currents that are both transient, owing to fast inactivation, and tiny, owing to small conductance. T-type channels are thought to be involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance, and rebound burst firing. Many alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: caveolin-3, Cav3.3, CAN, RUNX3, p16
Papers on CACNA1G
Cannabinoid receptor agonists modulate calcium channels in rat retinal müller cells.
Wang et al., Shanghai, China. In Neuroscience, Feb 2016
In the present work we show that three subunits of T-type Ca(2+) channels, CaV3.1, CaV3.2 and CaV3.3, as well as one subunit of L-type Ca(2+) channels, CaV1.2, were expressed in rat Müller cells by immunofluorescent staining.
Compensatory reduction of Cav3.1 expression in thalamocortical neurons of juvenile rats of WAG/Rij model of absence epilepsy.
Shuba et al., Kiev, Ukraine. In Epilepsy Res, Jan 2016
The expression level of G isoform (Cav3.1)
No apparent role for T-type Ca(2+) channels in renal autoregulation.
Sorensen et al., Copenhagen, Denmark. In Pflugers Arch, Jan 2016
The role of T- and L-type calcium channels in the response to acute increases in RPP in T-type channel knockout mice (CaV3.1)
In vitro synergistic anticancer activity of the combination of T-type calcium channel blocker and chemotherapeutic agent in A549 cells.
Lee et al., Seoul, South Korea. In Bioorg Med Chem Lett, Jan 2016
UNASSIGNED: As a result of our continuous research, new 3,4-dihydroquinazoline derivative containing ureido group, KCP10043F was synthesized and evaluated for T-type Ca(2+) channel (Cav3.1)
Evaluation of CpG Island Methylator Phenotype as a Biomarker in Colorectal Cancer Treated With Adjuvant Oxaliplatin.
Grady et al., Seattle, United States. In Clin Colorectal Cancer, Dec 2015
CIMP status was determined using the DNA methylation status of CACNA1G, IGF2, NEUROG1, RUNX3, and SOCS1.
Anatomical Localization of CaV3.1 Calcium Channels and Electrophysiological Effects of T-type Calcium Channel Blockade in the Thalamus of MPTP-Treated Monkeys.
Wichmann et al., München, Germany. In J Neurophysiol, Dec 2015
At the electron microscopic level, dendrites accounted for more than 90% of all tissue elements that were immunoreactive for Cav3.1-containing
Functional importance of T-type voltage-gated calcium channels in the cardiovascular and renal system: news from the world of knockout mice.
Hansen, Odense, Denmark. In Am J Physiol Regul Integr Comp Physiol, Mar 2015
Two types of T-type channels, Cav3.1 and Cav3.2, are expressed in blood vessels, the kidney, and the heart.
[Cognitive Function and Calcium. Cognitive improvement through T type calcium channel stimulation].
Fukunaga, Japan. In Clin Calcium, Feb 2015
Three subtypes of T-type Ca2+ channels Cav3.1 (α1G), Cav3.2 (α1H), Cav3.3 (α1I) encoding by CACNA1G, CACNA1H, CACNA1I genes have been cloned.
Functional role of voltage gated Ca(2+) channels in heart automaticity.
Mangoni et al., Montpellier, France. In Front Physiol, 2014
or T-type Cav3.1 (Cav3.1(-/-))
Ca-α1T, a fly T-type Ca(2+) channel, negatively modulates sleep.
Jones et al., Taejŏn, South Korea. In Sci Rep, 2014
Mammalian T-type Ca(2+) channels are encoded by three separate genes (Cav3.1, 3.2, 3.3).
A mutation in the low voltage-gated calcium channel CACNA1G alters the physiological properties of the channel, causing spinocerebellar ataxia.
Kawakami et al., Hiroshima, Japan. In Mol Brain, 2014
RESULTS: In this study, we analyzed a Japanese family with autosomal dominant SCA using linkage analysis and exome sequencing, and identified CACNA1G, which encodes the calcium channel CaV3.1, as a new causative gene.
T-type channel-mediated neurotransmitter release.
Vandael et al., Torino, Italy. In Pflugers Arch, 2014
Growing evidence over the last 10 years suggests a key role of Cav3.2 and Cav3.1 channels in controlling basal neurosecretion near resting conditions and sustained release during mild stimulations.
Cardiac functions of voltage-gated Ca(2+) channels: role of the pharmacoresistant type (E-/R-Type) in cardiac modulation and putative implication in sudden unexpected death in epilepsy (SUDEP).
Schneider et al., Köln, Germany. In Rev Physiol Biochem Pharmacol, 2013
In the myocardium, the Cav1 subfamily (L-type: Cav1.2 and Cav1.3) is the main contributor to excitation-contraction coupling and/or pacemaking, whereas the Cav3 subfamily (T-type: Cav3.1 and Cav3.2) is important in rhythmically firing of the cardiac nodal cells.
ZnT-1 enhances the activity and surface expression of T-type calcium channels through activation of Ras-ERK signaling.
Etzion et al., Beersheba, Israel. In Am J Physiol Cell Physiol, 2012
Augmentation of CaV3.1 currents by Ras-ERK activation is associated with enhanced trafficking of channels to the plasma membrane.
T-type voltage-activated calcium channel Cav3.1, but not Cav3.2, is involved in the inhibition of proliferation and apoptosis in MCF-7 human breast cancer cells.
Yamazaki et al., Fukuoka, Japan. In Int J Oncol, 2012
Cav3.1 channels may contribute to the repression of tumor proliferation and the promotion of apoptosis mediated via Cav3.1-specific calcium signals
Functional importance of L- and P/Q-type voltage-gated calcium channels in human renal vasculature.
Jensen et al., Odense, Denmark. In Hypertension, 2011
Data showed expression of L-type (Ca(v) 1.2), P/Q-type (Ca(v) 2.1), and T-type subtype (Ca(v) 3.1 and Ca(v) 3.2) voltage-gated calcium channels (Ca(v)s) in renal artery and dissected intrarenal blood vessels from nephrectomies.
Blockade of T-type Ca(2+) channels inhibits human ovarian cancer cell proliferation.
Li et al., Shenyang, China. In Cancer Invest, 2011
The function of T-type Ca(2+) channels is important for the proliferation of human ovarian cancer cells.
Regulation and function of Cav3.1 T-type calcium channels in IGF-I-stimulated pulmonary artery smooth muscle cells.
Cribbs et al., Maywood, United States. In Am J Physiol Cell Physiol, 2011
Cav3.1 T-type channels interact with divalent calcium ion-dependent steps of the mitogenic signaling cascade as a central component of vascular remodeling in disease.
The role of voltage-gated calcium channels in pancreatic beta-cell physiology and pathophysiology.
Berggren et al., Stockholm, Sweden. In Endocr Rev, 2006
At least six CaValpha1 subunits, including CaV1.2, CaV1.3, CaV2.1, CaV2.2, CaV2.3, and CaV3.1, have been identified in pancreatic beta-cells.
Colorectal cancer with mutation in BRAF, KRAS, and wild-type with respect to both oncogenes showing different patterns of DNA methylation.
Matsubara et al., Okayama, Japan. In J Clin Oncol, 2004
PATIENTS AND METHODS: Activating mutations of BRAF and KRAS were identified and correlated with promoter methylation of 11 loci, including MINT1, MINT2, MINT31, CACNA1G, p16(INK4a), p14(ARF), COX2, DAPK, MGMT, and the two regions in hMLH1 in 468 CRCs and matched normal mucosa.
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