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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Cdk5 and Abl enzyme substrate 1

Cables, ik3-1, Cables1
This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127).Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] (from NCBI)
Top mentioned proteins: PCNA, CAN, ABL, Cyclin-Dependent Kinase 5, cdk3
Papers on Cables
From Wires to Cables: Attempted Synthesis of 1,3,5-Trifluorenylcyclohexane as a Platform for Molecular Cables.
New
Rathore et al., In J Org Chem, Feb 2016
As an example of the platform for constructing molecular cables, 1,3,5-trifluorenylcyclohexane (TFC) and its difluorenyl analogues (DFCs) were systematically investigated both experimentally (X-Ray crystallography) and theoretically (DFT calculations).
The Cables1 gene in glucocorticoid regulation of pituitary corticotrope growth and Cushing disease.
New
Drouin et al., Montréal, Canada. In J Clin Endocrinol Metab, Jan 2016
Surgery sections from CD patients were used to assess expression of CABLES1 in corticotrope adenomas.
Elastin Cables Define the Axial Connective Tissue System in the Murine Lung.
New
Mentzer et al., Mainz, Germany. In Anat Rec (hoboken), Nov 2015
The axial connective tissue system is a fiber continuum of the lung that maintains alveolar surface area during changes in lung volume.
Coil-Type Asymmetric Supercapacitor Electrical Cables.
New
Thomas et al., United States. In Small, Nov 2015
Cable-shaped supercapacitors (SCs) have recently aroused significant attention due to their attractive properties such as small size, lightweight, and bendability.
Tangential Bicortical Locked Fixation Improves Stability in Vancouver B1 Periprosthetic Femur Fractures: A Biomechanical Study.
New
Reid et al., Paraguay. In J Orthop Trauma, Oct 2015
The distal femur segment was osteotomized, and plates were fixed proximally with either (1) cerclage cables, (2) locked unicortical screws, (3) a composite of locked screws and cables, or tangentially directed bicortical locking screws using either (4) a stainless steel locking compression plate system with a Locking Attachment Plate (Synthes) or (5) a titanium alloy Non-Contact Bridging system (Zimmer).
Antenna Mechanism of Length Control of Actin Cables.
New
Kondev et al., Waltham, United States. In Plos Comput Biol, Jun 2015
Actin cables are linear cytoskeletal structures that serve as tracks for myosin-based intracellular transport of vesicles and organelles in both yeast and mammalian cells.
Cables1 controls p21/Cip1 protein stability by antagonizing proteasome subunit alpha type 3.
New
Khuri et al., Guangzhou, China. In Oncogene, Jun 2015
Here we report a novel regulatory mechanism that controls the dynamic status of p21 through its interaction with Cdk5 and Abl enzyme substrate 1 (Cables1).
Ex vivo evaluation of carpal flexion after partial carpal arthrodesis in horses.
New
Panizzi et al., Saskatoon, Canada. In Vet Surg, Apr 2015
Cables and deadweights were connected to limbs and each angle of flexion determined 3 times using a protractor and then averaged.
Cables1 complex couples survival signaling to the cell death machinery.
Khuri et al., Guangzhou, China. In Cancer Res, 2015
Cables1 is a candidate tumor suppressor that negatively regulates cell growth by inhibiting cyclin-dependent kinases.
Associations between menarche-related genetic variants and pubertal growth in male and female adolescents.
He et al., Indianapolis, United States. In J Adolesc Health, 2015
Among the nine menarche-timing and height-related SNPs, four (in or near genes ZBTB38, LOC728666, TBX2, and CABLES) were associated with changes in weight or height in EA and AA (p ≤ .0042).
Damping Estimation from Free Decay Responses of Cables with MR Dampers.
Distl et al., Dübendorf, Switzerland. In Scientificworldjournal, 2014
This paper discusses the damping measurements on cables with real-time controlled MR dampers that were performed on a laboratory scale single strand cable and on cables of the Sutong Bridge, China.
Exposure Assessment of a High-energy Tensile Test With Large Carbon Fiber Reinforced Polymer Cables.
Wang et al., Dübendorf, Switzerland. In J Occup Environ Hyg, 2014
This study investigated the particle and fiber release from two carbon fiber reinforced polymer cables that underwent high-energy tensile tests until rupture.
Smart monitoring system based on adaptive current control for superconducting cable test.
Svelto et al., Napoli, Italy. In Rev Sci Instrum, 2014
83, 095111 (2012)] of the Facility for the Research on Superconducting Cables, achieving a significant performance improvement: a reduction in the system overshoot by 50%, with a related attenuation of the corresponding dynamic residual error (both absolute and RMS) up to 52%.
No association of polymorphisms in the CDK5, NDEL1, and LIS1 with autism in Chinese Han population.
GeneRIF
Zhang et al., Beijing, China. In Psychiatry Res, 2012
The results did not detect a significant association. It indicated that common genetic variations in CDK5 genes might not play a role in the genetic predisposition to autism.
Cables1 protects p63 from proteasomal degradation to ensure deletion of cells after genotoxic stress.
GeneRIF
Tilly et al., Boston, United States. In Embo Rep, 2010
Data show that oocytes lacking Cables1 exhibit lower basal levels of TAp63alpha and reduced accumulation of phosphorylated TAp63alpha in response to genotoxic stress.
Mechanisms of Cables 1 gene inactivation in human ovarian cancer development.
GeneRIF
Rueda et al., Boston, United States. In Cancer Biol Ther, 2008
Mechanisms of CABLES1 gene inactivation in ovarian cancer development are reported.
Loss of CABLES1, a cyclin-dependent kinase-interacting protein that inhibits cell cycle progression, results in germline expansion at the expense of oocyte quality in adult female mice.
GeneRIF
Rueda et al., Boston, United States. In Cell Cycle, 2007
Cables1 null mice exhibit a significant expansion of oocyte numbers at the expense of oocyte quality throughout adulthood.
The Cables gene on chromosome 18q is silenced by promoter hypermethylation and allelic loss in human colorectal cancer.
GeneRIF
Zukerberg et al., Boston, United States. In Am J Pathol, 2007
Loss of Cables expression in 65% of CRCs suggests that it is a common event in colonic carcinogenesis, with promoter methylation and LOH appearing to be important mechanisms of Cables gene inactivation.
Cables links Robo-bound Abl kinase to N-cadherin-bound beta-catenin to mediate Slit-induced modulation of adhesion and transcription.
Impact
Balsamo et al., Iowa City, United States. In Nat Cell Biol, 2007
Here we show that on binding of Slit to Robo, the adaptor protein Cables is recruited to Robo-associated Abl and forms a multimeric complex by binding directly to N-cadherin-associated beta-catenin.
Cable plates and onlay allografts in periprosthetic femoral fractures after hip replacement: laboratory and clinical observations.
Review
Duncan et al., Vancouver, Canada. In Instr Course Lect, 2003
Cables rather than smooth wires should be used for fixation, and fixation strength increases with the number of cables used.
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