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Stromal cell derived factor 4

Cab45, SDF4, 45 kDa calcium-binding protein
This gene encodes a stromal cell derived factor that is a member of the CREC protein family. The encoded protein contains six EF-hand motifs and calcium-binding motifs. This protein localizes to the Golgi lumen and may be involved in regulating calcium dependent cellular activities. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: ACID, CAN, profilin, Calu, SDF-2
Papers on Cab45
Targeted identification of sialoglycoproteins in hypoxic endothelial cells and validation in zebrafish reveal roles for proteins in angiogenesis.
New
Bono et al., Saint-Pierre-des-Corps, France. In J Biol Chem, Mar 2015
Second, we identified several new proteins regulated by hypoxia and demonstrated for the first time the pivotal role of GLUT-1, TMEM16F, and SDF4 in angiogenesis.
Secretory cargo sorting at the trans-Golgi network.
Review
von Blume et al., Martinsried, Germany. In Trends Cell Biol, 2014
Recent discoveries have revealed a novel sorting mechanism that requires the linkage between the cytoplasmic actin cytoskeleton to the membrane-anchored Ca(2+) ATPase, SPCA1 (secretory pathway calcium ATPase 1), and the luminal 45 kDa Ca(2+)-binding protein, Cab45, for successful sorting of a subset of proteins at the TGN.
Stromal cell derived factor-2 (Sdf2): a novel protein expressed in mouse.
Bevilacqua et al., São Paulo, Brazil. In Int J Biochem Cell Biol, 2014
SDF1 and SDF4 are chemokines; SDF2 and SDF5 are not yet functionally and structurally defined.
[The effects of simulated microgravity on the pattern of gene expression in human bone marrow mesenchymal stem cells under osteogenic differentiation].
Buravkova et al., In Fiziol Cheloveka, 2013
Interestingly, some of the genes with down-regulated expression were related to the bone development and differentiation (COL15A1, CXCL12, DPTand WISP2) or participated in the cell-to-cell communications ofhMSCs with other cell types (CXCL12, SDF4).
Cab45 is required for Ca(2+)-dependent secretory cargo sorting at the trans-Golgi network.
Malhotra et al., Martinsried, Germany. In J Cell Biol, 2013
We show here that a soluble, lumenal Golgi resident protein, Cab45, is required for SPCA1-dependent Ca(2+) import into the TGN; it binds secretory cargo in a Ca(2+)-dependent reaction and is required for its sorting at the TGN.
Exome sequencing identifies a spectrum of mutation frequencies in advanced and lethal prostate cancers.
Shendure et al., Seattle, United States. In Proc Natl Acad Sci U S A, 2011
A subset of genes was recurrently altered across tumors derived from different individuals, including TP53, DLK2, GPC6, and SDF4.
A novel endoplasmic reticulum export signal: proline at the +2-position from the signal peptide cleavage site.
Tomida et al., Tokyo, Japan. In J Biol Chem, 2009
Interestingly, such a Pro(+2) has also been functionally conserved in other Golgi-localized soluble proteins, Cab45 (Ca(2+)-binding protein of 45 kDa), reticulocalbin 1, and calumenin.
Cab45b, a Munc18b-interacting partner, regulates exocytosis in pancreatic beta-cells.
GeneRIF
Gaisano et al., Toronto, Canada. In J Biol Chem, 2009
The results suggest a mechanism for Cab45b action that involves regulating the dynamic association of Munc18b with SNAREs to impact beta-cell granule exocytosis.
Transcript analyses of stromal cell derived factors (SDFs): SDF-2, SDF-4 and SDF-5 reveal a different pattern of expression and prognostic association in human breast cancer.
GeneRIF
Jiang et al., Cardiff, United Kingdom. In Int J Oncol, 2009
SDF-2, SDF-4 and SDF-5 are expressed in mammary tissues and cells and that a reduced level of SDF-2 and SDF-4 are associated with a poor clinical outcome.
Secretome-based proteomics reveals sulindac-modulated proteins released from colon cancer cells.
Simpson et al., Australia. In Proteomics Clin Appl, 2009
Our secretome-based proteomic studies have identified several secreted modulators of sulindac-induced apoptosis action (e.g., Mac-2 binding protein, Alix, 14-3-3 isoforms, profilin-1, calumenin/Cab45 precursors, and the angiogenic/tumor growth factors interleukin 8 (IL-8) and growth related oncogene (GRO-α)) that are likely to improve our understanding of the chemopreventitive action of this NSAID in CRC.
The rapidly expanding CREC protein family: members, localization, function, and role in disease.
Review
Honoré, Århus, Denmark. In Bioessays, 2009
The CREC family of low affinity, Ca2+-binding, multiple EF-hand proteins are encoded by five genes, RCN1, RCN2, RCN3, SDF4, and CALU, resulting in reticulocalbin, ER Ca2+-binding protein of 55 kDa (ERC-55), reticulocalbin-3, Ca2+-binding protein of 45 kDa (Cab45), and calumenin.
The ethanol response gene Cab45 can modulate the impairment elicited by ethanol and ultraviolet in PC12 cells.
Li et al., Beijing, China. In J Genet Genomics, 2008
As a member of new calcium binding protein family, the exact role of Cab45 still remains unclear.
MLPA as a screening method of aneuploidy and unbalanced chromosomal rearrangements in spontaneous miscarriages.
Lorda-Sanchez et al., Spain. In Prenat Diagn, 2007
Copy number variation was found for target sequences of P036B (CYFIP1, MRPL41, CAB45) and P070 (DECR2, TNFRSF18) probe mixes.
A cytosolic splice variant of Cab45 interacts with Munc18b and impacts on amylase secretion by pancreatic acini.
GeneRIF
Olkkonen et al., Toronto, Canada. In Mol Biol Cell, 2007
In a yeast two-hybrid screen the EF-hand Ca(2+)-binding protein Cab45 was identified as an interaction partner of Munc18b.
A proteomic approach reveals transient association of reticulocalbin-3, a novel member of the CREC family, with the precursor of subtilisin-like proprotein convertase, PACE4.
Matsuda et al., Tokushima, Japan. In Biochem J, 2006
RCN-3 is a member of the CREC (Cab45/reticulocalbin/ERC45/calumenin) family of multiple EF-hand Ca2+-binding proteins localized to the secretory pathway.
The CREC family, a novel family of multiple EF-hand, low-affinity Ca(2+)-binding proteins localised to the secretory pathway of mammalian cells.
Review
Vorum et al., Århus, Denmark. In Febs Lett, 2000
At present, the family includes reticulocalbin, ERC-55/TCBP-49/E6BP, Cab45, calumenin and crocalbin/CBP-50.
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