gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Eukaryotic translation initiation factor 6

CAB, eukaryotic translation initiation factor 3, eIF6, GCN
Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, CLOCK, V1a
Papers using CAB antibodies
ojoplano-mediated basal constriction is essential for optic cup morphogenesis.
Supplier
Callaerts Patrick, In PLoS ONE, 2008
... The following strains were used for medaka embryos: The Cab wild type strain, the Heino albino strain, and the transgenic lines Ath5::GFP and Rx2::H2B-RFP ...
Papers on CAB
Role of senescence marker p16(INK4a) measured in peripheral blood T-lymphocytes in predicting length of hospital stay after coronary artery bypass surgery in older adults.
New
Walston et al., Baltimore, United States. In Exp Gerontol, Feb 2016
Adults older than 65years undergo more than 120,000 coronary artery bypass (CAB) procedures each year in the United States.
Indoleamine 2,3‑dioxygenase downregulates T‑cell receptor complex ζ‑chain and c‑Myc, and reduces proliferation, lactate dehydrogenase levels and mitochondrial glutaminase in human T‑cells.
New
Stefanidis et al., Lárisa, Greece. In Mol Med Report, Jan 2016
Indoleamine 2,3‑dioxygenase (IDO), through L‑tryptophan depletion, activates general control non‑derepressible (GCN) 2 kinase and suppresses T‑cell proliferation, in addition to suppressing aerobic glycolysis and glutaminolysis, which are required for these rapidly proliferating cells.
Functional relationship between mTERF4 and GUN1 in retrograde signaling.
New
Leister et al., Martinsried, Germany. In J Exp Bot, Jan 2016
In this study, we isolated a mutant exhibiting up-regulation of CHLOROPHYLL A/B-BINDING PROTEIN (CAB) under normal growth conditions (named coe1 for CAB overexpression 1).
MYB96 shapes the circadian gating of ABA signaling in Arabidopsis.
New
Seo et al., Chŏnju, South Korea. In Sci Rep, Dec 2015
MYB96 directly binds to the TIMING OF CAB EXPRESSION 1 (TOC1) promoter to positively regulate its expression.
Deletion of the gene family of small chlorophyll-binding proteins (ScpABCDE) offsets C/N homeostasis in synechocystis PCC 6803.
New
Funk et al., Umeå, Sweden. In Biochim Biophys Acta, Dec 2015
UNASSIGNED: In the family of chlorophyll binding proteins, single helix small CAB-like proteins (SCPs) are found in all organisms performing oxygenic photosynthesis.
eIF6 anti-association activity is required for ribosome biogenesis, translational control and tumor progression.
Review
New
Biffo et al., Milano, Italy. In Biochim Biophys Acta, Jul 2015
Here we discuss the function of eukaryotic initiation factor 6 (eIF6; Tif6 in yeast).
The urothelium: anatomy, review of the literature, perspectives for veterinary medicine.
Review
New
Arrighi, Milano, Italy. In Ann Anat, Mar 2015
The review was prepared consulting the electronic databases PubMed and Cab Abstracts and retrieving all pertinent reports and the relative reference lists, in order to identify any potential additional studies that could be included.
A systematic review of the efficacy of prophylactic control measures for naturally-occurring canine leishmaniosis, part I: vaccinations.
Review
Solano-Gallego et al., Barcelona, Spain. In Prev Vet Med, 2014
Four bibliographic databases (CAB Direct 2011, Web of Science 2011, U.S. National Library of Medicine 2011 and Literatura Latino Americana e do Caribe em Ciências da Saúde) were searched along with eight sets of conference proceedings and the International Veterinary Information Service (IVIS) database, from 1980 to November 2012.
GnRH agonists and the rapidly increasing use of combined androgen blockade in prostate cancer.
Review
Labrie, Québec, Canada. In Endocr Relat Cancer, 2014
Taking into account these novel facts, combined androgen blockade (CAB) using a pure antiandrogen combined with castration in order to block the two sources of androgens was first published in 1982.
Leaf senescence and nitrogen remobilization efficiency in oilseed rape (Brassica napus L.).
Review
Etienne et al., Caen, France. In J Exp Bot, 2014
The development of a relevant molecular indicator (SAG12/Cab) of leaf senescence progression in combination with a (15)N-labelling method were used to decipher the N remobilization associated with sequential senescence and to determine modulation of this process by abiotic factors especially N deficiency.
Level of HER2 gene amplification predicts response and overall survival in HER2-positive advanced gastric cancer treated with trastuzumab.
Impact
Lopez-Rios et al., Oviedo, Spain. In J Clin Oncol, 2014
PURPOSE: Previous studies have highlighted the importance of an appropriate human epidermal growth factor receptor 2 (HER2) evaluation for the proper identification of patients eligible for treatment with anti-HER2 targeted therapies.
Deletion of chromosome 20 in bone marrow of patients with Shwachman-Diamond syndrome, loss of the EIF6 gene and benign prognosis.
GeneRIF
Maserati et al., In Br J Haematol, 2012
The benign prognosis of the Shwachman-Diamond syndrome patients with the int del (20)(q11.21q13.32) may be due to a gene/dosage effect for the EIF6 protein.
Identification of ITGB4BP as a new interaction protein of P311.
GeneRIF
Wu et al., China. In Life Sci, 2012
The interactions between P311 and ITGB4BP may be very important in the process of tumor cell differentiation and metastasis.
Mapping the core of the Arabidopsis circadian clock defines the network structure of the oscillator.
Impact
Mas et al., Barcelona, Spain. In Science, 2012
In Arabidopsis, oscillator coupling relies on a core loop in which the evening oscillator component TIMING OF CAB EXPRESSION 1 (TOC1) was proposed to activate a subset of morning-expressed oscillator genes.
Global landscape of HIV-human protein complexes.
Impact
Krogan et al., San Francisco, United States. In Nature, 2012
We uncovered a number of host complexes targeted by viral proteins, including the finding that HIV protease cleaves eIF3d, a subunit of eukaryotic translation initiation factor 3. This host protein is one of eleven identified in this analysis that act to inhibit HIV replication.
The translation factor eIF6 is a Notch-dependent regulator of cell migration and invasion.
GeneRIF
Londei et al., Roma, Italy. In Plos One, 2011
eIF6 is one of the downstream effectors of Notch-1 in the pathway that controls cell motility and invasiveness in tumor cell lines
Proteomic and protein interaction network analysis of human T lymphocytes during cell-cycle entry.
GeneRIF
Thomas et al., London, United Kingdom. In Mol Syst Biol, 2011
Inhibiting the induction of two proteins involved in two of the most significantly upregulated cellular processes, ribosome biogenesis (eIF6) and hnRNA splicing (SF3B2/SF3B4), showed that human T cells can enter the cell cycle without growing in size.
Crystal structure of the eukaryotic 60S ribosomal subunit in complex with initiation factor 6.
Impact
Ban et al., Zürich, Switzerland. In Science, 2011
We present the structure of the 60S ribosomal subunit from Tetrahymena thermophila in complex with eukaryotic initiation factor 6 (eIF6), cocrystallized with the antibiotic cycloheximide (a eukaryotic-specific inhibitor of protein synthesis), at a resolution of 3.5 angstroms.
Impairment of cytoplasmic eIF6 activity restricts lymphomagenesis and tumor progression without affecting normal growth.
Impact
GeneRIF
Biffo et al., Milano, Italy. In Cancer Cell, 2011
eIF6 is a rate-limiting controller of initiation of translation, able to affect tumorigenesis and tumor growth.
share on facebooktweetadd +1mail to friends