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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Mucin 16, cell surface associated

CA-125
The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential, but the function of this protein is unknown. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, AGE, CAN, fibrillin-1, CEA
Papers using CA-125 antibodies
Relaxing the rule of ten events per variable in logistic and Cox regression
Supplier
Amant F et al., In British Journal of Cancer, 2006
... CA-125 levels were available, although the decision on response was based on RECIST only.Second, at the time of IDS, response was assessed according ...
Papers on CA-125
Metabolic tumor burden predicts prognosis of ovarian cancer patients who receive platinum-based adjuvant chemotherapy.
New
Yoshida et al., Fukui, Japan. In Cancer Sci, Feb 2016
Metabolic tumor burden in terms of metabolic tumor volume (MTV) and total lesion glycolysis (TLG), clinical stage, histological type, residual tumor after primary cytoreductive surgery, baseline serum carbohydrate antigen 125 (CA125) level, and the maximum standardized uptake value (SUVmax ) were determined, and compared for their performance in predicting progression-free survival (PFS).
Prognostic value of measuring the diameter and inspiratory collapse of the inferior vena cava in acute heart failure.
New
Pérez-Calvo et al., Zaragoza, Spain. In Rev Clin Esp, Feb 2016
NT-proBNP (P=.009) and CA125 (P=.005).
Diagnostic significance of soluble human leukocyte antigen-G for gastric cancer.
New
Yan et al., Linhai, China. In Hum Immunol, Feb 2016
The serum levels of alpha feroprotein (AFP), carcinoembryonic antigen (CEA), cancer antigen 125 (CA125), cancer antigen 19-9 (CA19-9) and cancer antigen 72-4 (CA72-4) were also determined.
Ovarian cancer screening and mortality in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial.
New
Impact
Skates et al., London, United Kingdom. In Lancet, Jan 2016
The trial management system confirmed eligibility and randomly allocated participants in blocks of 32 using computer-generated random numbers to annual multimodal screening (MMS) with serum CA125 interpreted with use of the risk of ovarian cancer algorithm, annual transvaginal ultrasound screening (USS), or no screening, in a 1:1:2 ratio.
The lack of clinical value of peritoneal washing cytology in high risk patients undergoing risk-reducing salpingo-oophorectomy: a retrospective study and review.
New
van Beekhuizen et al., Rotterdam, Netherlands. In Bmc Cancer, Dec 2015
Patients with an elevated risk of malignancy prior to the procedure were excluded from primary analysis (elevated CA-125, an ovarian mass, abdominal pain or another gynecological malignancy).
Understanding the Unique Attributes of MUC16 (CA125): Potential Implications in Targeted Therapy.
Review
New
Batra et al., Omaha, United States. In Cancer Res, Dec 2015
Since the identification of CA125 to be MUC16, it is hypothesized to undergo proteolytic cleavage, a process that is considered to be critical in determining the kinetics of MUC16 shedding as well as generation of a cell-associated carboxyl-terminal fragment with potential oncogenic functions.
Diagnostic values of osteopontin combined with CA125 for ovarian cancer: a meta-analysis.
Review
New
Xi et al., Chengdu, China. In Fam Cancer, Nov 2015
This meta-analysis aims to ascertain whether OPN is a useful diagnostic biomarker for OC and determine the overall diagnostic accuracy of OPN measurement when combined with cancer antigen 125 (CA125).
Risk Algorithm Using Serial Biomarker Measurements Doubles the Number of Screen-Detected Cancers Compared With a Single-Threshold Rule in the United Kingdom Collaborative Trial of Ovarian Cancer Screening.
New
Impact
Jacobs et al., Middlesbrough, United Kingdom. In J Clin Oncol, Jul 2015
PATIENTS AND METHODS: In the United Kingdom Collaborative Trial of Ovarian Cancer Screening, 46,237 women, age 50 years or older underwent incidence screening by using the multimodal strategy (MMS) in which annual serum cancer antigen 125 (CA-125) was interpreted with the risk of ovarian cancer algorithm (ROCA).
The Role of CA 125 as Tumor Marker: Biochemical and Clinical Aspects.
Review
Scatena et al., Roma, Italy. In Adv Exp Med Biol, 2014
CA 125 also known as mucin 16 or MUC16 is a large membrane glycoprotein belonging to the wide mucin family, encoded by the homonymous MUC16 gene.
Epithelioid Sarcoma: Opportunities for Biology-Driven Targeted Therapy.
Review
Keller et al., Fort Collins, United States. In Front Oncol, 2014
In this review, we will summarize clinically relevant biomarkers (e.g., SMARCB1, CA125, dysadherin, and others) with respect to targeted therapeutic opportunities.
microRNA and Ovarian Cancer.
Review
Langhe, Dublin, Ireland. In Adv Exp Med Biol, 2014
Current diagnostic tools include imaging and CA125 have their limitations in terms of accuracy.There is a strong need for prognostic and predictive markers to diagnose it early and to help optimize and personalize treatment.
Ovarian fibrosarcoma: case report and latest trends in diagnostic and therapeutic management.
Balbi et al., In Eur J Gynaecol Oncol, 2014
Diagnostic imaging revealed a solid- cystic inhomogeneous mass occupying the right adnexa and the CA125 level was elevated.
Pathologic findings at risk-reducing salpingo-oophorectomy: primary results from Gynecologic Oncology Group Trial GOG-0199.
Impact
Greene et al., Bethesda, United States. In J Clin Oncol, 2014
Women provided risk factor data and underwent preoperative cancer antigen 125 (CA-125) serum testing and transvaginal ultrasound (TVU).
Longitudinal screening algorithm that incorporates change over time in CA125 levels identifies ovarian cancer earlier than a single-threshold rule.
Impact
McIntosh et al., Seattle, United States. In J Clin Oncol, 2013
We demonstrated improvement in ovarian cancer early detection by using a longitudinal algorithm to monitor annual CA125 levels.
Results of annual screening in phase I of the United Kingdom familial ovarian cancer screening study highlight the need for strict adherence to screening schedule.
Impact
Jacobs et al., London, United Kingdom. In J Clin Oncol, 2013
PURPOSE: To establish the performance characteristics of annual transvaginal ultrasound and serum CA125 screening for women at high risk of ovarian/fallopian tube cancer (OC/FTC) and to investigate the impact of delayed screening interval and surgical intervention.
The mucin MUC16 (CA125) binds to NK cells and monocytes from peripheral blood of women with healthy pregnancy and preeclampsia.
GeneRIF
Patankar et al., Madison, United States. In Am J Reprod Immunol, 2012
MUC16 binding to NK cells and monocytes likely contributes to tolerance of the fetal allograft from maternal responses and may also serve as a novel biomarker for preeclampsia.
High serum carbohydrate antigen-125 (CA-125) level predicts poor outcome in patients with follicular lymphoma independently of the FLIPI score.
GeneRIF
Papajík et al., Olomouc, Czech Republic. In Int J Hematol, 2012
high CA-125 levels as a prognostic factor for overall and progression-free survival rates independent of Follicular Lymphoma International Prognostic Index score variables. CA-125 levels may help to refine risk assessment in the modern immunotherapy era.
Coexpression of MUC16 and mesothelin is related to the invasion process in pancreatic ductal adenocarcinoma.
GeneRIF
Yamaue et al., Wakayama, Japan. In Cancer Sci, 2012
we identified two specific genes, MUC16 and mesothelin, associated with the invasion process in patients with PDAC.
Carbohydrate antigen-125 and N-terminal pro-brain natriuretic peptide levels: compared in heart-failure prognostication.
GeneRIF
Kandis et al., Düzce, Turkey. In Tex Heart Inst J, 2011
Conclude that baseline CA-125 and NT-proBNP levels are comparably reliable as heart-failure markers, and that CA-125 can be used for prognosis prediction in heart failure.
The prognostic values of CA125, CA19.9, NSE, AND SCC for stage I NSCLC are limited.
GeneRIF
Chen et al., Beijing, China. In Cancer Biomark, 2010
Data show that the prognostic values of CA125, CA19.9, neuron-speci fi c enolase (NSE), and squamous cell carcinoma antigen (SCC) for stage I non-small-cell lung cancer NSCLC are limited.
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