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Carbonic anhydrase XII

CA XII, CA12, carbonic anhydrase XII
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Two transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: carbonic anhydrase IX, CAN, ACID, HAD, SET
Papers on CA XII
Fluorescent sulfonamide carbonic anhydrase inhibitors incorporating 1,2,3-triazole moieties: Kinetic and X-ray crystallographic studies.
New
Supuran et al., Sesto Fiorentino, Italy. In Bioorg Med Chem, Feb 2016
CA XII (KIs of 4.1-20.5nM)
Inhibition of carbonic anhydrase potentiates bevacizumab treatment in cholangiocarcinoma.
New
Okada et al., Kumamoto, Japan. In Tumour Biol, Feb 2016
VEGF neutralization by bevacizumab effectively reduced tumor growth, mainly through the suppression of angiogenesis; however, increases in the expression of hypoxia-inducible factor 1α (HIF1α) and HIF1α-responsive genes (such as VEGF, VEGFR1, VEGFR2, carbonic anhydrase (CA) IX and CAXII) indicated the potential for subsequent therapeutic resistance.
Development of certain new 2-substituted-quinazolin-4-yl-aminobenzenesulfonamide as potential antitumor agents.
New
Supuran et al., Portugal. In Eur J Med Chem, Feb 2016
Certain selected derivatives were tested for their ability to inhibit four isoforms of the metalloemzyme CA, namely, CA I, CA II, CA IX and CA XII.
Inhibition of carbonic anhydrase isoforms I, II, IV, VII and XII with carboxylates and sulfonamides incorporating phthalimide/phthalic anhydride scaffolds.
New
Supuran et al., Riyadh, Saudi Arabia. In Bioorg Med Chem, Feb 2016
They were synthesized from substituted anthranilic acids and trimellitic anhydride chloride, followed by reaction with primary amines and were tested for the inhibition of five physiologically relevant CA isoforms, the human (h) hCA I, II, IV, VII and XII, some of which are involved in serious pathologies (CA II, IV and XII in glaucoma; CA VII in epilepsy; CA XII in some solid tumors).
Governing effect of regulatory proteins for Cl(-)/HCO3(-) exchanger 2 activity.
New
Hong et al., Inch'ŏn, South Korea. In Channels (austin), Jan 2016
The main goal of the present study was to investigate potential regulators, such as spinophilin (SPL), inositol-1,4,5-trisphosphate [IP3] receptors binding protein released with IP3 (IRBIT), STE20/S;PS1-related proline/a;lanine-rich kinase (SPAK) kinase, and carbonic anhydrase XII (CA XII).
Essential role of carbonic anhydrase XII in secretory gland fluid and HCO3 (-) secretion revealed by disease causing human mutation.
New
Muallem et al., Bethesda, United States. In J Physiol, Jan 2016
Carbonic anhydrase XII (CA12) is the key carbonic anhydrase in epithelial fluid and HCO3 (-) secretion and works by activating the ductal Cl(-) -HCO3 (-) exchanger AE2.
α-Imaging Confirmed Efficient Targeting of CD45-Positive Cells After 211At-Radioimmunotherapy for Hematopoietic Cell Transplantation.
New
Sandmaier et al., Göteborg, Sweden. In J Nucl Med, Nov 2015
Our goal was to optimize the anti-CD45 monoclonal antibody (mAb; CA12.10C12) protein dose for (211)At-radioimmunotherapy, extending the analysis to include intraorgan (211)At activity distribution and α-imaging-based small-scale dosimetry, along with immunohistochemical staining.
Sex Differences in Varenicline Efficacy for Smoking Cessation: A Meta-Analysis.
New
Weinberger et al., New Haven, United States. In Nicotine Tob Res, Nov 2015
Varenicline versus placebo outcomes demonstrated that varenicline was more effective for women for short and intermediate outcomes (PP-12, CA-12, CA-24; P < .05
[Analysis on the change of genotype of enteroviruses associated hand, foot and mouth disease in Beijing during 2013 to 2014].
New
Zhu et al., In Zhonghua Er Ke Za Zhi, Aug 2015
Twenty six of the 89 other EVs included CA2, CA5, CA8, CA9, CA12, CA14, CB2, CB5, E6, E9 and E25, each genotype of which was no more than 3.
Carbonic anhydrase IX inhibitors in cancer therapy: an update.
Review
Winum et al., Sesto Fiorentino, Italy. In Future Med Chem, 2014
These enzymes are of clinical relevance in cancer therapy as among the 15 isoforms known in humans, two cell surface CA isoforms, namely CA IX (almost exclusively associated with tumors) and CA XII (overexpressed in some tumor types) are involved in tumorigenesis.
The impact of PPARα activation on whole genome gene expression in human precision cut liver slices.
Kersten et al., Wageningen, Netherlands. In Bmc Genomics, 2014
Finally, several putative new target genes of PPARα were identified that were commonly induced by PPARα activation in the two human liver model systems, including TSKU, RHOF, CA12 and VSIG10L.
Tumor hypoxia and metabolism -- towards novel anticancer approaches.
Review
Pouysségur et al., Nice, France. In Ann Endocrinol (paris), 2013
We reported that targeting these pHi-regulated processes through inhibition of either HIF-1-induced CAIX/CAXII or HIF-1-induced MCT4, MCT1 or Basigin/EMMPRIN/CD147 chaperone of MCTs, severely restricts glycolysis-generated ATP levels and tumor growth.
Gadolinium-1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid-icosahedral closo-borane12 scaffold conjugated with Glu-{Glu-[cyclo(Arg-Gly-Asp-d-Phe-Lys)]2}2
Review
Leung, Bethesda, United States. In Unknown Journal, 2013
Goswami et al. (21) utilized [closoB12(OH)12](2–) as a high payload MRI contrast agent (CA-12) carrying eleven copies of Gd-DOTA chelates and one copy of Glu-Glu-{[cyclo(Arg-Gly-Asp-d-Phe-Lys)]2}2 (cRGD) via PEG linkers for use as a high-performance MRI contrast agent in nude mice bearing human breast cancer xenografts.
Anticancer carbonic anhydrase inhibitors: a patent review (2008 - 2013).
Review
De Simone et al., Napoli, Italy. In Expert Opin Ther Pat, 2012
EXPERT OPINION: A consistent number of patents on molecules able to inhibit the catalytic activity of CA IX and CA XII have been recently reported.
Tumor-associated carbonic anhydrase XII is linked to the growth of primary oral squamous cell carcinoma and its poor prognosis.
GeneRIF
Yang et al., Taipei, Taiwan. In Oral Oncol, 2012
The expression of CA XII in oral squamous cell carcinoma (OSCC) samples can predict the progression of OSCC and survival of OSCC patients.
CAXII Is a sero-diagnostic marker for lung cancer.
GeneRIF
Sato et al., Japan. In Plos One, 2011
Serum CAXII levels were significantly higher in lung cancer patients than in healthy controls, providing evidence that CAXII may be a novel sero-diagnostic marker for lung cancer.
Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors.
GeneRIF
Pirmohamed et al., Liverpool, United Kingdom. In Pharmacogenet Genomics, 2011
The development of acidosis with topiramate and zonisamide is not determined by drug dose or by treatment duration, but may be influenced by polymorphisms in the gene for CA type XII.
Autosomal recessive hyponatremia due to isolated salt wasting in sweat associated with a mutation in the active site of Carbonic Anhydrase 12.
GeneRIF
Parvari et al., Beersheba, Israel. In Hum Genet, 2011
Study identified the association of a Glu143Lys mutation in carbonic anhydrase 12 (CA12) with the disease.
Carbonic anhydrase XII expression is associated with histologic grade of cervical cancer and superior radiotherapy outcome.
GeneRIF
Song et al., South Korea. In Radiat Oncol, 2009
CA12 may be used as a novel prognostic marker in combination with histologic grade of invasive cervical cancer.
Saliva as a tool for oral cancer diagnosis and prognosis.
Review
Nagler, Haifa, Israel. In Oral Oncol, 2009
In recent years, significant alterations have been demonstrated in the saliva of oral cancer patients in the epithelial tumor markers--Cyfra 21-1, TPS and CA12, various oxidative stress-related salivary parameters as ROS and RNS, biochemical and immunological parameters as IGF and MMP's and RNA transcripts of IL8, IL-1B, DUSP1, HA3, OAZ1, S100P, and SAT.
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