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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Carbonic anhydrase VI

CA VI, carbonic anhydrase VI, CA6, gustin, salivary carbonic anhydrase
The protein encoded by this gene is one of several isozymes of carbonic anhydrase. This protein is found only in salivary glands and saliva and protein may play a role in the reversible hydratation of carbon dioxide though its function in saliva is unknown. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, HAD, fibrillin-1, CAN, AGE
Papers on CA VI
Gene-environment Interactions in the Etiology of Dental Caries.
New
Türel et al., Isparta, Turkey. In J Dent Res, Jan 2016
The aim of this study is to examine the effects of AMELX, CA6, DEFB1, and TAS2R38 gene polymorphism and gene-environment interactions on caries etiology and susceptibility in adults.
Construction and characterization of an infectious clone of coxsackievirus A6 that showed high virulence in neonatal mice.
New
Xia et al., Xiamen, China. In Virus Res, Jan 2016
It is believed that coxsackievirus A6 (CA6) is the major pathogen for aHFMD.
Making the diagnosis of Sjögren's syndrome in patients with dry eye.
Review
New
Milner et al., Westerville, United States. In Clin Ophthalmol, Dec 2015
Recently, newer biomarkers have been identified, including autoantibodies to salivary gland protein-1, parotid secretory protein, and carbonic anhydrase VI, and may allow for earlier diagnosis of SS.
Changes in the salivary protein profile of morbidly obese women either previously subjected to bariatric surgery or not.
New
do Carmo et al., Évora, Portugal. In J Physiol Biochem, Dec 2015
One interesting finding was the high correlation between levels of CA VI and body mass index in group O, which was not observed for groups O-BS or C. The differences between groups, mainly regarding salivary proteins involved in taste sensitivity and metabolism, point to the potential of using saliva in the study of obesity development.
[Epidemiological surveillance of hand, foot and mouth disease in Shanghai, 2010-2014].
New
Zeng et al., Shanghai, China. In Zhonghua Er Ke Za Zhi, Sep 2015
The detection rates of CA6 and CA10 in the mild community cases in 2014 were 18.38% and 1.43%, respectively.
[Analysis on the change of genotype of enteroviruses associated hand, foot and mouth disease in Beijing during 2013 to 2014].
New
Zhu et al., In Zhonghua Er Ke Za Zhi, Aug 2015
The positive rates of CA16, EV71, CA6, CA10, CA4 and other EVs were 25. 6% (250/977), 18. 9% (185/977), 20.
[Pathogenic and clinical presentation of bullous rash in hand, foot and mouth disease].
New
Wang et al., In Zhonghua Er Ke Za Zhi, Aug 2015
RESULT: In the clinically diagnosed HFMD cases who were characterized by widespread mucocutaneous bullous reactions, 207 were caused by coxsackievirus A6 (CA6), accounting for 92.
[The etiological and clinical characteristics of hospitalized children with hand, foot and mouth disease in Beijing in 2013].
New
Li et al., Beijing, China. In Zhonghua Er Ke Za Zhi, Jun 2015
HFMD was more likely developed in children under 2 years of age (81.6%, 102/125); 11 different enteroviruses were genotyped, with a total enterovirus positive rate of 76.6% (98/128); the positive rate of coxsackievirus A6 (CA6), 43.0% ( 55/128), was the highest, followed by enterovirus 71 (EV71), accounting for 14.8% (19/128).
A Taste-intensity Visual Analog Scale: An Improved Zinc Taste-test Protocol.
New
Saling et al., Morgantown, United States. In Integr Med (encinitas), Apr 2015
These findings have included, but were not limited to, relationships between zinc sulfate taste acuity and weight, levels of serum zinc, diastolic hypertension, levels of salivary carbonic anhydrase 6, and frequency of illness.
Coxsackievirus A6: a new emerging pathogen causing hand, foot and mouth disease outbreaks worldwide.
Review
Liang et al., Beijing, China. In Expert Rev Anti Infect Ther, 2014
However, since a HFMD caused by coxsackievirus A6 broke out in Finland in 2008, CA6 has been identified as the responsible pathogen for a series of HFMD outbreaks in Europe, North America and Asia.
Molecular mechanisms of taste recognition: considerations about the role of saliva.
Review
Fábián et al., Denmark. In Int J Mol Sci, 2014
Besides these, data clearly indicate the major role of several other salivary proteins, such as salivary carbonic anhydrase (gustin), proline-rich proteins, cystatins, alpha-amylases, histatins, salivary albumin and mucins.
Genotypes of the Enterovirus Causing Hand Foot and Mouth Disease in Shanghai, China, 2012-2013.
Xu et al., Shanghai, China. In Plos One, 2014
The most frequent genotypes were CA6 (31.9%),
Genetic sensitivity to the bitter taste of 6-n-propylthiouracil (PROP) and its association with physiological mechanisms controlling body mass index (BMI).
Review
Tomassini Barbarossa et al., New Brunswick, United States. In Nutrients, 2014
This review describes genetic factors that may contribute to PROP sensitivity including: (1) the variants of the TAS2R38 bitter receptor with their different affinities for the stimulus; (2) the gene that controls the gustin protein that acts as a salivary trophic factor for fungiform taste papillae; and (3) other specific salivary proteins that could be involved in facilitating the binding of the PROP molecule with its receptor.
The investigation of genetic polymorphisms in the carbonic anhydrase VI gene exon 2 and salivary parameters in type 2 diabetic patients and healthy adults.
GeneRIF
Yarat et al., İstanbul, Turkey. In Mol Biol Rep, 2012
The aim of this study was to investigate carbonic anhydrase (CA) VI Exon 2 single nucleotide polymorphism (SNP) and its possible association with salivary parameters in type 2 diabetic patients compared to healthy adults.
Crystal structure of the secretory isozyme of mammalian carbonic anhydrases CA VI: implications for biological assembly and inhibitor development.
GeneRIF
Yue et al., Oxford, United Kingdom. In Biochem Biophys Res Commun, 2012
The 1.9A crystal structure of the human CA VI catalytic domain reveals a prototypical mammalian CA fold, and a novel dimeric arrangement as compared to previously-reported CA structures.
Polymorphisms in TAS2R38 and the taste bud trophic factor, gustin gene co-operate in modulating PROP taste phenotype.
GeneRIF
Barbarossa et al., Monserrato, Italy. In Physiol Behav, 2011
The data of this study showed how the combination of the TAS2R38 and gustin gene genotypes modulate PROP phenotype.
A rapid screening method for the identification of a single-nucleotide polymorphism in the carbonic anhydrase VI gene in studies of sensitivity to the bitter taste of 6-n-propylthiouracil.
GeneRIF
Padiglia et al., Monserrato, Italy. In Genet Test Mol Biomarkers, 2011
The polymerase chain reaction followed by restriction fragment length polymorphism assay described here can be used as an alternative to sequencing in bitter taster status research, and could be employed as a survey tool in nutrigenomic studies.
Altered ion-responsive gene expression in Mmp20 null mice.
GeneRIF
Bartlett et al., Boston, United States. In J Dent Res, 2010
expression of Car6 significantly decreased in enamel organs from Mmp20(-/-) mice. A feedback mechanism regulates ion-responsive gene expression during enamel development.
Carbonic anhydrases as drug targets--an overview.
Review
Supuran, Sesto Fiorentino, Italy. In Curr Top Med Chem, 2006
Some of these isozymes are cytosolic (CA I, CA II, CA III, CA VII, CA XIII), others are membrane-bound (CA IV, CA IX, CA XII, CA XIV and CA XV), CA VA and CA VB are mitochondrial, and CA VI is secreted in saliva and milk.
Human carbonic anhydrases and carbonic anhydrase deficiencies.
Review
Impact
Hu et al., Saint Louis, United States. In Annu Rev Biochem, 1994
They differ in subcellular localizations, being cytoplasmic (CA I, II, III, and VII), GPI-anchored to plasma membranes of specialized epithelial and endothelial cells (CA IV), in mitochondria (CA V), or in salivary secretions (CA VI).
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