Generating iPSC-Derived Choroidal Endothelial Cells to Study Age-Related Macular Degeneration.
Iowa City, United States. In Invest Ophthalmol Vis Sci, Jan 2016
Induced pluripotent stem cell-derived CECs express carbonic anhydrase IV, eNOS, FOXA2, PLVAP, CD31, CD34, ICAM-1, Tie2, TTR, VE-cadherin, and vWF.
IsoCombretaQuinazolines: Potent Cytotoxic Agents with Antitubulin Activity.
Châtenay-Malabry, France. In Chemmedchem, Aug 2015
The isoCoQ compounds 2-methoxy-5-(1-(2-methylquinazolin-4-yl)vinyl)phenol (4 b), 4-[1-(3-fluoro-4-methoxyphenyl)vinyl]-2-methylquinazoline (4 c), and 2-methoxy-5-(1-(2-methylquinazolin-4-yl)vinyl)aniline (4 d), which respectively bear the greatest resemblance to isoCA-4, isoFCA-4, and isoNH2 CA-4, are able to arrest HCT116 cancer cells in the G2 /M cell-cycle phase at very low concentrations.
Human carbonic anhydrases and carbonic anhydrase deficiencies.
Saint Louis, United States. In Annu Rev Biochem, 1994
They differ in subcellular localizations, being cytoplasmic (CA I, II, III, and VII), GPI-anchored to plasma membranes of specialized epithelial and endothelial cells (CA IV), in mitochondria (CA V), or in salivary secretions (CA VI).