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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Carbonic anhydrase IV

CA IV, carbonic anhydrase IV, CA-4, RP17
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This gene encodes a glycosylphosphatidyl-inositol-anchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and proximal renal tubules. Its exact function is not known; however, it may have a role in inherited renal abnormalities of bicarbonate transport. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, HAD, CAN, V1a, CIs
Papers on CA IV
Photoswitchable anticancer activity via trans-cis isomerization of a combretastatin A-4 analog.
Hartman et al., Richmond, United States. In Org Biomol Chem, Feb 2016
Azo-CA4 is less potent than CA-4 because it degrades in the presence of glutathione as evidenced by UV-Vis spectroscopy and ESI-MS.
Normal Fertility Requires the Expression of Carbonic Anhydrases II and IV in Sperm.
Wennemuth et al., Essen, Germany. In J Biol Chem, Jan 2016
We show that two CA isoforms, CAII and CAIV, are distributed along the epididymal epithelium and appear with the onset of puberty.
Generating iPSC-Derived Choroidal Endothelial Cells to Study Age-Related Macular Degeneration.
Tucker et al., Iowa City, United States. In Invest Ophthalmol Vis Sci, Jan 2016
Induced pluripotent stem cell-derived CECs express carbonic anhydrase IV, eNOS, FOXA2, PLVAP, CD31, CD34, ICAM-1, Tie2, TTR, VE-cadherin, and vWF.
Role of JNK and NF-κB in mediating the effect of combretastatin A-4 and brimamin on endothelial and carcinoma cells.
Biersack et al., Bayreuth, Germany. In Cell Oncol (dordr), Dec 2015
PURPOSE: The 4,5-diarylimidazole brimamin is an analog of the natural vascular-disrupting agent combretastatin A-4 (CA-4) with improved water solubility, tolerance by animals and efficacy in multidrug-resistant tumors.
Synthesis and Biological Evaluations of 1,2-Diaryl Pyrroles as Analogues of Combretastatin A-4.
Zhang et al., Zhengzhou, China. In Chem Biol Drug Des, Dec 2015
A series of novel 1,2-diaryl pyrroles as analogues of combretastatin A-4 (CA-4, 1a) were synthesized and evaluated for their antitumour potential against three cancer cell lines.
Synthesis and biological evaluation of novel 4,5-disubstituted 2H-1,2,3-triazoles as cis-constrained analogues of combretastatin A-4.
Crooks et al., Little Rock, United States. In Eur J Med Chem, Nov 2015
A series of combretastatin A-4 (CA-4) analogues have been prepared from (Z)-substituted diarylacrylonitriles (1a-1p) obtained in a two-step synthesis from appropriate arylaldehydes and acrylonitriles.
Renal plasticity in response to feeding in the Burmese python, Python molurus bivittatus.
Grosell et al., Austin, United States. In Comp Biochem Physiol A Mol Integr Physiol, Oct 2015
CA IV expression was significantly down-regulated at 3 dpf versus fasted controls.
IsoCombretaQuinazolines: Potent Cytotoxic Agents with Antitubulin Activity.
Alami et al., Châtenay-Malabry, France. In Chemmedchem, Aug 2015
The isoCoQ compounds 2-methoxy-5-(1-(2-methylquinazolin-4-yl)vinyl)phenol (4 b), 4-[1-(3-fluoro-4-methoxyphenyl)vinyl]-2-methylquinazoline (4 c), and 2-methoxy-5-(1-(2-methylquinazolin-4-yl)vinyl)aniline (4 d), which respectively bear the greatest resemblance to isoCA-4, isoFCA-4, and isoNH2 CA-4, are able to arrest HCT116 cancer cells in the G2 /M cell-cycle phase at very low concentrations.
Carbonic anhydrase IV inhibits colon cancer development by inhibiting the Wnt signalling pathway through targeting the WTAP-WT1-TBL1 axis.
Yu et al., Hong Kong, Hong Kong. In Gut, Jul 2015
OBJECTIVE: We found that carbonic anhydrase IV (CA4), a member of the carbonic anhydrases, is silenced in colorectal cancer (CRC).
Recent advances in vascular disrupting agents in cancer therapy.
Viola et al., Padova, Italy. In Future Med Chem, 2014
Tubulin-binding agents represent the largest group of VDAs and are characterized by different chemical structures, although most of them are derivatives of the lead compound combretastatin (CA-4).
Membrane associated carbonic anhydrase IV (CA IV): a personal and historical perspective.
Sly et al., Saint Louis, United States. In Subcell Biochem, 2013
Carbonic anhydrase IV is one of 12 active human isozymes and one of four expressed on the extracellular surfaces of certain endothelial and epithelial cells.
Tubulin-interactive stilbene derivatives as anticancer agents.
Różański et al., Poznań, Poland. In Cell Mol Biol Lett, 2013
Combretastatin A-4 (3'-hydroxy-3,4,4',5-tetramethoxy-cis-stilbene; CA-4) is a potent cytotoxic cis-stilbene that binds to β-tubulin at the colchicine-binding site and inhibits tubulin polymerization.
Carbonic anhydrase VI exon 2 genetic polymorphism in Turkish subjects with low caries experience (preliminary study).
Isbir et al., İstanbul, Turkey. In In Vivo, 2011
Two SNPs of carbonic anhydrase IV, which are responsible for amino acid changes, were found. The frequencies of these SNPs were not significantly different between the caries-free group and the group with caries
Transport activity of the high-affinity monocarboxylate transporter MCT2 is enhanced by extracellular carbonic anhydrase IV but not by intracellular carbonic anhydrase II.
Becker et al., Kaiserslautern, Germany. In J Biol Chem, 2011
data suggest that extracellular membrane-bound CAIV, but not cytosolic CAII, augments transport activity of MCT2 in a non-catalytic manner, possibly by facilitating a proton pathway other than His-88
Carbonic anhydrases in the mouse harderian gland.
Parkkila et al., Tampere, Finland. In J Mol Histol, 2010
Car4, Car6, and Car12 showed moderate expression levels in the mouse harderian gland.
Biological potential and structure-activity relationships of most recently developed vascular disrupting agents: an overview of new derivatives of natural combretastatin a-4.
Menichini et al., Rende, Italy. In Curr Med Chem, 2010
The antimitotic agent combretastatin A-4 (CA-4), a cis-stilbene natural product isolated from the South African tree Combretum caffrum Kuntze, is the lead compound of a new class of anti-cancer drugs that target tumor vasculature.
Developments of combretastatin A-4 derivatives as anticancer agents.
Dong et al., Xi'an, China. In Curr Med Chem, 2010
Combretastatin A-4 (CA-4) is a potent anticancer and antiangiogenesis natural substance isolated from Combretum caffrum.
Cell-specific differences in the processing of the R14W CAIV mutant associated with retinitis pigmentosa 17.
Prince et al., Cape Town, South Africa. In J Cell Biochem, 2010
compared the subcellular localization and post-translational processing of wild-type (WT)- and retinitis pigmentosa 17 mutant-CAIV in three cell types
Role of carbonic anhydrase IV in the bicarbonate-mediated activation of murine and human sperm.
Wennemuth et al., Homburg, Germany. In Plos One, 2009
Data show a 32.13% reduction in total CA activity in CA IV(-/-) mice.
Human carbonic anhydrases and carbonic anhydrase deficiencies.
Hu et al., Saint Louis, United States. In Annu Rev Biochem, 1994
They differ in subcellular localizations, being cytoplasmic (CA I, II, III, and VII), GPI-anchored to plasma membranes of specialized epithelial and endothelial cells (CA IV), in mitochondria (CA V), or in salivary secretions (CA VI).
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