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Complement component 8, alpha polypeptide

C8A
C8 is a component of the complement system and contains three polypeptides, alpha, beta and gamma. This gene encodes the alpha subunit of C8. C8 participates in the formation of the membrane attack complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause complement C8 alpha-gamma deficiency. [provided by RefSeq, Nov 2008] (from NCBI)
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Top mentioned proteins: C8B, ACID, CAN, POLYMERASE, OUT
Papers on C8A
Quaternary Indolizidine and Indolizidone Iminosugars as Potential Immunostimulating and Glycosidase Inhibitory Agents: Synthesis, Conformational Analysis, Biological Activity, and Molecular Docking Study.
New
Dhavale et al., Pune, India. In J Med Chem, Nov 2015
New quaternary indolizidine iminosugars, with hydroxymethyl group at the ring junction, namely, C-8a-hydroxymethyl-1-deoxycastanospermine congeners 1a, 2a, 3a and their 3-oxo analogs 1b, 2b, and 3b were synthesized by using intramolecular reductive aminocyclization/lactamization of d-mannose/D-glucose derived C5-γ-azido esters as a key step wherein both the rings of the indolizidine skeleton were built up in one pot following the cascade reaction pathway.
Identification of Circulating Biomarker Candidates for Hepatocellular Carcinoma (HCC): An Integrated Prioritization Approach.
Janjua et al., Islamabad, Pakistan. In Plos One, 2014
Finally, interactome analysis of these proteins with midkine (MDK), dickkopf-1 (DKK-1), current standard HCC biomarker alpha-fetoprotein (AFP), its interacting partners in conjunction with HCC-specific circulating and liver deregulated miRNAs target filtration highlighted seven novel statistically significant putative biomarkers including complement component 8, alpha (C8A), mannose binding lectin (MBL2), antithrombin III (SERPINC1), 11β-hydroxysteroid dehydrogenase type 1 (HSD11B1), alcohol dehydrogenase 6 (ADH6), beta-ureidopropionase (UPB1) and cytochrome P450, family 2, subfamily A, polypeptide 6 (CYP2A6).
Mechanistic studies on the dibenzofuran formation from phenanthrene, fluorene and 9-fluorenone.
Zhang et al., Jinan, China. In Int J Mol Sci, 2014
Dibenzofuran will be formed if ∙OH adds to C8a, and the order of reactivity follows as 9-fluorenone > 9-methylfluorene > fluorene > phenanthrene.
Evolution of an oxidative dearomatization enabled total synthesis of vinigrol.
Das et al., Ithaca, United States. In Org Biomol Chem, 2014
The logic of its selection and the group's importance beyond protecting the C8a hydroxyl group is presented along with a discussion of strategies for its removal.
Genetic engineering of Streptomyces bingchenggensis to produce milbemycins A3/A4 as main components and eliminate the biosynthesis of nanchangmycin.
Xiang et al., In Appl Microbiol Biotechnol, 2013
Enzymatic analysis indicated that MilD can catalyze both α-class (A3/A4) and β-class milbemycins (β11) into C5-O-methylmilbemycins B2/B3 and β1, respectively, suggesting little effect of furan ring formed between C6 and C8a on the C5-O-methylation catalyzed by MilD.
Myelin basic protein undergoes a broader range of modifications in mammals than in lower vertebrates.
Andrews et al., Ann Arbor, United States. In J Proteome Res, 2012
Other modifications found in bovine MBP include N-terminal acetylation in components C1, C2, and C3; oxidation of methionine 19 in all five components; all charge isomers having both a mono- and dimethylated (symmetric) arginine at position 106; deimination in arginines 23 and 47 found only in component C8b; deimination of arginine 96 and deamidation in glutamine 102 found in components C2, C3, C8a, and C8b; phosphorylation in threonine 97 restricted to charge components C2 and C3; deimination in arginine 161 only found in component C3; deamidation of glutamine 120 was only observed in C3.
Experimental and theoretical analyses of azulene synthesis from tropones and active methylene compounds: reaction of 2-methoxytropone and malononitrile.
Nozoe et al., Saitama, Japan. In J Org Chem, 2012
(c) A nucleophilic addition of the second HC(CN)(2)(-) toward the imine 6 at the C-8a position produces the second Meisenheimer-type adduct 7. (d) The second ring closure leads to 1-carbamoyl-1,3-dicyano-2-imino-2,3-dihydroazulene (11).
Genetic variability of the coding region for the prion protein gene (PRNP) in gayal (Bos frontalis).
Deng et al., Kunming, China. In Mol Biol Rep, 2012
A total of ten single nucleotide polymorphisms (SNPs), including six silent mutations (C60T, G75A, A108T, G126A, C357T and C678T) and four mis-sense mutations (C8A, G145A, G461A and C756G), corresponding to amino acids T3K, G49S9, N154S and I252M were identified, revealing high genetic diversity.
Biophysical analysis of influenza A virus RNA promoter at physiological temperatures.
Kim et al., Rochester, United States. In J Biol Chem, 2011
We also found that a nonfunctional RNA promoter containing the 3'-G3U mutation, as well as a promoter containing the compensatory 3'-G3U/C8A mutations, was able to form a duplex as efficiently as wild type.
Mapping the intermedilysin-human CD59 receptor interface reveals a deep correspondence with the binding site on CD59 for complement binding proteins C8alpha and C9.
GeneRIF
Tweten et al., Oklahoma City, United States. In J Biol Chem, 2011
Mapping the intermedilysin-human CD59 receptor interface reveals a deep correspondence with the binding site on CD59 for complement binding proteins C8alpha and C9.
Coding polymorphisms in the genes of the alternative complement pathway and abdominal aortic aneurysm.
Hughes et al., Belfast, United Kingdom. In Int J Immunogenet, 2011
This study tested 49 single nucleotide polymorphisms, including common putatively functional polymorphisms, in the genes of the alternative complement cascade (CFH, CFB, CFD, CFI, properdin, CR1, CR1L, CR2, CD46, vitronectin, C3, C5, C6, C7, C8A, C8B, C8G and C9).
Nitrenium ion-mediated alkene bis-cyclofunctionalization: total synthesis of (-)-swainsonine.
Bowen et al., Chicago, United States. In Org Lett, 2011
The pivotal transformation in our route to this indolizidine alkaloid is the formation of the pyrrolidine ring and C-8a/8 stereodiad through the diastereoselective, bis-cyclofunctionalization of an γ,δ-unsaturated O-alkyl hydroxamate.
The three-way relationship of polymorphisms of porcine genes encoding terminal complement components, their differential expression, and health-related phenotypes.
Ponsuksili et al., Germany. In Bmc Proc, 2010
The terminal complement components (TCCs: C6, C7, C8A, C8B, and C9) are encoded by the genes C6, C7, C8A, C8B, C8G, and C9.
Laser spectroscopy of conformationally constrained alpha/beta-peptides: Ac-ACPC-Phe-NHMe and Ac-Phe-ACPC-NHMe.
Zwier et al., West Lafayette, United States. In J Phys Chem A, 2010
Here, the ACPC ring selectively stabilizes the C8a ring over other possible C8 structures.
Selective removal of individual disulfide bonds within a potato type II serine proteinase inhibitor from Nicotiana alata reveals differential stabilization of the reactive-site loop.
Craik et al., Brisbane, Australia. In J Mol Biol, 2010
To investigate the influence of these two disulfide bonds on the structure and function of potato II inhibitors, we constructed two variants of T1, C4A/C41A-T1 and C8A/C37A-T1, in which these two disulfide bonds were individually removed and replaced by alanine residues.
A disulfide linked model of the complement protein C8gamma complexed with C8alpha indel peptide.
GeneRIF
Stavrakoudis, Ioánnina, Greece. In J Mol Model, 2009
C8gamma binds an indel peptide of C8alpha sequence and forms a non-covalent complex.
Crystal structure of the MACPF domain of human complement protein C8 alpha in complex with the C8 gamma subunit.
GeneRIF
Sodetz et al., Columbia, United States. In J Mol Biol, 2008
Results describe the crystal structure of the human C8 alpha MACPF domain disulfide-linked to C8 gamma (alphaMACPF-gamma) at 2.15 A resolution.
Role of apoptosis signal-regulating kinase 1 in complement-mediated glomerular epithelial cell injury.
GeneRIF
Cybulsky et al., Montréal, Canada. In Mol Immunol, 2008
The present study thus defines a novel role for ASK1 as a mediator of C5b-9-dependent cell injury.
Structure of C8alpha-MACPF reveals mechanism of membrane attack in complement immune defense.
Impact
GeneRIF
Gros et al., Utrecht, Netherlands. In Science, 2007
crystal structure of the MACPF domain of complement component C8alpha at 2.5 angstrom resolution was determined and it was shown that it is structurally homologous to the bacterial, pore-forming, cholesterol-dependent cytolysins
["Death and survival of neuronal cells exposed to Alzheimer's disease-relevant insults"].
Review
Nishimoto, Tokyo, Japan. In Nihon Yakurigaku Zasshi, 2002
C8A-HN lost the activity and S14G-HN had approximately 1000 times increased potency of its action.
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