Acute lung injury and the role of histones.
Ann Arbor, United States. In Transl Respir Med, 2013
Extracellular histone appearance required both C5a receptors (C5aR, C5L2) as well as neutrophils (PMNs) and lung macrophages, as genetic loss of either C5a receptor or depletion of PMNs or macrophages reduced histone levels found in BALF during ALI.
Structure, function and control of complement C5 and its proteolytic fragments.
Århus, Denmark. In Curr Mol Med, 2012
The small anaphylatoxin C5a induces a variety of biological responses upon binding to the 7TM receptors C5aR and the C5L2, while the large C5b fragment nucleates formation of the membrane attack complex capable of killing susceptible pathogens by the formation of a pore structure in association with complement components C6, C7, C8, and C9.
Functional roles for C5a receptors in sepsis.
Ann Arbor, United States. In Nat Med, 2008
C5l2 is required for the release of HMGB1, is a functional receptor and contributes synergistically with C5ar to the harmful consequences in sepsis.