The effect of nuclear factor of activated T-cells (NFAT) in kidney I/R mediated by C5a/C5aR.
Wuhan, China. In Int J Clin Exp Med, 2014
To investigate the relationship between NFAT and C5a/C5aR in C5a/C5aR-mediated kidney Ischemia/reperfusion (I/R) injury, the rats' NRK-52E cell line was used in this study and was distributed into 4 groups, I: the normal control (NC), II: the ischemia/reperfusion (I/R) injury cell model (MG), III: the ischemia/reperfusion (I/R) injury cell model treated with C5a (50 nmol/l) (MG + C5a), IV: the ischemia/reperfusion (I/R) injury cell model treated with C5aR antagonist (2.5 μmol/l) (MG + anti-C5aR).
Acute lung injury and the role of histones.
Ann Arbor, United States. In Transl Respir Med, 2013
We have studied experimental acute lung injury (ALI) in mice following airway deposition of bacterial lipopolysaccharide (LPS) or the recombinant mouse complement anaphylatoxin, C5a.
Eculizumab for paroxysmal nocturnal haemoglobinuria.
Salt Lake City, United States. In Lancet, 2009
Eculizumab is a humanised monoclonal antibody that binds and prevents activation of complement C5 and the subsequent formation of the cytolytic membrane attack complex of complement.