Current concepts in C3 glomerulopathy.
Brisbane, Australia. In Indian J Nephrol, 2014
Complement component 3 glomerulopathy (C3G) is a recently defined entity comprising of dense deposit disease and C3 glomerulonephritis.
Inhibitory receptor signaling via tyrosine phosphorylation of the adaptor Crk.
Rockville, United States. In Immunity, 2008
Here, we showed that binding of inhibitory natural killer (NK) cell receptors to human leukocyte antigen (HLA) class I on target cells induced tyrosine phosphorylation of the adaptor Crk, concomitant with dephosphorylation of the guanine exchange factor Vav1. Furthermore, Crk dissociated from the guanine exchange factor C3G and bound to the tyrosine kinase c-Abl during inhibition.