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Sp7 transcription factor 7

C22, Osterix, Osx, SP7
This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein is a bone specific transcription factor and is required for osteoblast differentiation and bone formation.[provided by RefSeq, Jul 2010] (from NCBI)
Top mentioned proteins: Runx2, Osteocalcin, CAN, osteopontin, HAD
Papers using C22 antibodies
Wdr5 is essential for osteoblast differentiation
Supplier
de Crombrugghe Benoit et al., In The EMBO Journal, 2007
... Generation of cell lines stably transfected with an inducible Osx expression vectorMouse C2C12 cells were stably transfected with pTet-off (Clontech) and selected on neomycin ...
Age-related changes in the osteogenic differentiation potential of mouse bone marrow stromal cells.
Supplier
Shi Songtao, In PLoS ONE, 2007
... One-Step NBT/BCIP solution (#34042) from Pierce; SYBR Green PCR Master Mix (#4367659) from Applied Biosystems; Osx antibody (#ab22552) from Abcam Inc.; Runx2 (#130-3) monoclonal ...
Osteocyte dendrogenesis in static and dynamic bone formation: an ultrastructural study
Supplier
De Pol A. et al., In European Journal of Histochemistry : EJH, 2003
... Rabbit anti-Osx; mouse antiOCNGeneTex, Irvine, CA, USA ...
A new mathematical model for relative quantification in real-time RT-PCR.
Supplier
Agarwal Sudha, In PLoS ONE, 2000
... Osx-Cre transgenic animals were previously described ...
Ascorbic acid-dependent activation of the osteocalcin promoter in MC3T3-E1 preosteoblasts: requirement for collagen matrix synthesis and the presence of an intact OSE2 sequence.
Supplier
Bartell Paul A., In PLoS ONE, 1996
... IgGs and horseradish peroxidase-conjugated mouse or goat IgG from Santa Cruz (Santa Cruz, CA), and Osterix antibody from Abcam Inc ...
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Papers on C22
Multiple essential MT1-MMP functions in tooth root formation, dentinogenesis, and tooth eruption.
New
Foster et al., Beijing, China. In Matrix Biol, Feb 2016
In contrast, selective knock-out of MT1-MMP in Osterix-expressing mesenchymal cells, including osteoblasts and odontoblasts, recapitulated major defects from the global knock-out including altered HERS structure, short roots, defective dentin formation and mineralization, and reduced alveolar bone formation, although molars were able to erupt.
Toxoplasmosis in the Caribbean islands: literature review, seroprevalence in pregnant women in ten countries, isolation of viable Toxoplasma gondii from dogs from St. Kitts, West Indies with report of new T. gondii genetic types.
New
Krecek et al., Beltsville, United States. In Parasitol Res, Feb 2016
PCR-RFLP genotyping of cell culture derived tachyzoites using 10 genetic markers, SAG1, SAG2 (5' and 3' SAG2, and alt.SAG2) SAG3, BTUB, GRA6, c22-8, c29-2, L358, PK1, and Apico revealed that 4 isolates were ToxoDB PCR-RFLP genotype #2, and 2 were new genotypes #264 and #265.
Pannexin 3 and connexin 43 modulate skeletal development via distinct functions and expression patterns.
New
Yamada et al., Bethesda, United States. In J Cell Sci, Feb 2016
Panx3 promoted expression of osteogenic genes such as ALP, Ocn, and Cx43 by regulating Osx expression.
Molecular detection and genetic characterization of Toxoplasma gondii infection in sika deer (Cervus nippon) in China.
New
Zhu et al., Lanzhou, China. In Infect Genet Evol, Feb 2016
During August 2014 to November 2014, a total of 450 tissue samples coming from 150 sika deer were collected to detect the T. gondii B1 gene using a nested PCR, and the positive samples were genotyped at 11 genetic markers (SAG1, 5'-and 3'-SAG2, alternative SAG2, SAG3, BTUB, GRA6, L358, PK1, c22-8, c29-2, and Apico) using multilocus polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technology.
Inhibition of TGFβ signaling decreases osteogenic differentiation of fibrodysplasia ossificans progressiva fibroblasts in a novel in vitro model of the disease.
New
Bravenboer et al., Amsterdam, Netherlands. In Bone, Feb 2016
During the course of transdifferentiation the osteogenic properties of the cells were evaluated by the mRNA expression of Sp7/Osterix, Runx2, Alp, OC and the presence of mineralization.
Site-specific function and regulation of Osterix in tooth root formation.
Review
New
Wu et al., Xi'an, China. In Int Endod J, Dec 2015
Recent studies have revealed that Osterix (Osx), a key mesenchymal transcriptional factor participating in both the processes of osteogenesis and odontogenesis, plays a vital role underlying the mechanisms of developmental differences between root and crown.
Selective regulation of Mmp13 by 1,25(OH)2D3, PTH, and Osterix through distal enhancers.
Review
New
Pike et al., Madison, United States. In J Steroid Biochem Mol Biol, Oct 2015
These activities occur through participation by the transcription factors VDR, RUNX2, FOS, JUN, and Osterix (OSX), respectively.
The critical and specific transcriptional regulator of the microenvironmental niche for hematopoietic stem and progenitor cells.
Review
New
Nagasawa et al., Kyoto, Japan. In Curr Opin Hematol, Jul 2015
RECENT FINDINGS: Osterix as well as Ebf2 and Bmi1 are critical but not specific transcriptional regulators of HSPC niche development.
What is new in genetics and osteogenesis imperfecta classification?
Review
Zabel et al., Belo Horizonte, Brazil. In J Pediatr (rio J), 2014
After 2006, mutations were identified in the CRTAP, FKBP10, LEPRE1, PLOD2, PPIB, SERPINF1, SERPINH1, SP7, WNT1, BMP1, and TMEM38B genes, associated with recessive OI and mutation in the IFITM5 gene associated with dominant OI.
Osteogenesis imperfecta due to mutations in non-collagenous genes: lessons in the biology of bone formation.
Review
Smith et al., Bethesda, United States. In Curr Opin Pediatr, 2014
Heat shock protein 47 (HSP47) and FK506-binding protein-65 (FKBP65) defects cause types X and XI osteogenesis imperfecta via aberrant collagen crosslinking, folding, and chaperoning, while defects in SP7 transcription factor, wingless-type MMTV integration site family member 1 (WNT1), trimeric intracellular cation channel type b (TRIC-B), and old astrocyte specifically induced substance (OASIS) disrupt osteoblast development.
Osteoblast-specific transcription factor Osterix (Osx) and HIF-1α cooperatively regulate gene expression of vascular endothelial growth factor (VEGF).
GeneRIF
Zhang et al., Beijing, China. In Biochem Biophys Res Commun, 2012
this study found that proline-rich region (PRR) is required for Osx activation of VEGF promoter activity, and that Osx cooperated with HIF-1a to positively regulate VEGF.
miR-93/Sp7 function loop mediates osteoblast mineralization.
GeneRIF
Luo et al., Changsha, China. In J Bone Miner Res, 2012
miR-93/Sp7 function loop mediates osteoblast mineralization
Characterization of Dkk1 gene regulation by the osteoblast-specific transcription factor Osx.
GeneRIF
de Crombrugghe et al., Dallas, United States. In Biochem Biophys Res Commun, 2012
these findings support our hypothesis that Dkk1 is a direct target of Osx.
Chondrocyte-specific ablation of Osterix leads to impaired endochondral ossification.
GeneRIF
Kim et al., Taegu, South Korea. In Biochem Biophys Res Commun, 2012
Osx regulates chondrocyte differentiation and bone growth in growth plate chondrocytes, suggesting an autonomous function of Osx in chondrocytes during endochondral ossification.
SP7 inhibits osteoblast differentiation at a late stage in mice.
GeneRIF
Komori et al., Nagasaki, Japan. In Plos One, 2011
SP7 and RUNX2 inhibit osteoblast differentiation at a late stage in a manner independent of RUNX2 and SP7, respectively, and SP7 positively regulates its own promoter
Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.
Impact
Genetic Factors for Osteoporosis (GEFOS) Consortium et al., Rotterdam, Netherlands. In Nat Genet, 2009
(LRP5), 12q13 (SP7), 13q14 (TNFSF11) and 18q21 (TNFRSF11A).
New sequence variants associated with bone mineral density.
Impact
Stefansson et al., Reykjavík, Iceland. In Nat Genet, 2009
These are near the SOST gene at 17q21, the MARK3 gene at 14q32, the SP7 gene at 12q13 and the TNFRSF11A (RANK) gene at 18q21.
NFAT and Osterix cooperatively regulate bone formation.
Impact
GeneRIF
Takayanagi et al., Tokyo, Japan. In Nat Med, 2005
NFAT and Osterix form a complex that binds to DNA, and this interaction is important for the transcriptional activity of Osterix and cooperative control of osteoblastic bone formation.
The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation.
Impact
de Crombrugghe et al., Houston, United States. In Cell, 2002
We have identified a novel zinc finger-containing transcription factor, called Osterix (Osx), that is specifically expressed in all developing bones.
Membranoproliferative glomerulonephritis associated with hepatitis C virus infection.
Impact
Alpers et al., Seattle, United States. In N Engl J Med, 1993
Cryoprecipitates from the three patients who were tested contained HCV RNA and IgG anti-HCV antibodies to the nucleocapsid core antigen (HCVc or c22-3).
More papers using C22 antibodies
Production of human cells expressing individual transferred HLA-A,-B,-C genes using an HLA-A,-B,-C null human cell line
Supplier
Unutmaz Derya, In PLoS ONE, 1988
... experiments were conducted according to the Regulation for Animal Experiments in Kumamoto University (Approval ID, C22-168: Analysis of immune responses against viral diseases by using humanized and HLA transgenic mice) ...
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