Characterising the immune profile of the kidney biopsy at lupus nephritis flare differentiates early treatment responders from non-responders.
Columbus, United States. In Lupus Sci Med, 2014
The top genes responsible for CR clustering included several interferon pathway genes (STAT1, IRF1, IRF7, MX1, STAT2, JAK2), while complement genes (C1R, C1QB, C6, C9, C5, MASP2) were mainly responsible for NR clustering.
Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans.
Atlanta, United States. In Nat Immunol, 2009
Computational analyses identified a gene signature, including complement protein C1qB and eukaryotic translation initiation factor 2 alpha kinase 4-an orchestrator of the integrated stress response-that correlated with and predicted YF-17D CD8(+) T cell responses with up to 90% accuracy in an independent, blinded trial.