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Complement component 1, q subcomponent, A chain

C1qa
This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the A-chain polypeptide of human complement subcomponent C1q. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: C1qB, AGE, CAN, HAD, SET
Papers on C1qa
C1q Modulates the Response to TLR7 Stimulation by Pristane-Primed Macrophages: Implications for Pristane-Induced Lupus.
New
Botto et al., London, United Kingdom. In J Immunol, Feb 2016
Surprisingly, C1qa(-/-) mice developed lower titers of circulating Abs and milder arthritis compared with the controls.
Early Complement Component Deficiency in a Single-Centre Cohort of Pediatric Onset Lupus.
New
Singh et al., Chandīgarh, India. In J Clin Immunol, Nov 2015
Mutation analysis of C1qA gene revealed a homozygous nonsense mutation: C1QA (NM_015991) c.622C>T, p.Q208X in one child.
Fc-Gamma Receptor Polymorphisms Predispose Patients to Infectious Complications After Liver Transplantation.
New
Ohdan et al., Hiroshima, Japan. In Am J Transplant, Nov 2015
The single-nucleotide polymorphisms (SNPs) of C1QA [276A/G], FCGR2A [131H/R], and FCGR3A [158F/V], genes encoding the Fc gamma receptor (FcγR), were analyzed in 89 living donor LT recipients in relation to the occurrences of postoperative infectious complications within 30 days after LT.
Changes in markers associated with dendritic cells driving the differentiation of either TH2 cells or regulatory T cells correlate with clinical benefit during allergen immunotherapy.
New
Moingeon et al., Antony, France. In J Allergy Clin Immunol, Nov 2015
At an individual patient level, DC2-associated markers, such as CD141, GATA3, OX40 ligand, and receptor-interacting serine/threonine-protein kinase 4 (RIPK4), were downregulated after a 4-month sublingual AIT course concomitantly with an upregulation of DCreg cell-associated markers, including complement C1q subcomponent subunit A (C1QA), FcγRIIIA, ferritin light chain (FTL), and solute carrier organic anion transporter family member 2B1 (SLCO2B1), in the blood of clinical responders as opposed to nonresponders.
APOE Stabilization by Exercise Prevents Aging Neurovascular Dysfunction and Complement Induction.
New
Howell et al., Boston, United States. In Plos Biol, Oct 2015
Neurovascular decline was sufficient to cause vascular leakage and correlated strongly with an increase in neuroinflammation including up-regulation of complement component C1QA in microglia/monocytes.
Variation in complement protein C1q is not a major contributor to cognitive impairment in Parkinson's disease.
New
Hudson et al., Newcastle upon Tyne, United Kingdom. In Neurosci Lett, Jun 2015
Given the links between C1q and cognitive function we assessed the genetic variability of the C1q encoding genes: C1QA, C1QB and C1QC between PD patients and matched controls.
Complement C1q-induced activation of β-catenin signalling causes hypertensive arterial remodelling.
Komuro et al., Tokyo, Japan. In Nat Commun, 2014
Macrophage depletion and C1qa gene deletion attenuated the hypertension-induced β-catenin signalling, proliferation of VSMCs and pathological arterial remodelling.
Bioinformatics Analysis of Potential Candidates for Therapy of TDRD7 Deficiency-Induced Congenital Cataract.
Wang et al., Beijing, China. In Ophthalmic Res, 2014
In the PPI network, high-degree genes of complement component 1, q subcomponent, A/B/C chain (C1QA/C1QB/C1QC), lymphocyte antigen 86 (LY86) and neuroblastoma RAS viral oncogene homolog (NRAS) were identified.
Differential Effects of C1qa Ablation on Glaucomatous Damage in Two Sexes in DBA/2NNia Mice.
Danias et al., New York City, United States. In Plos One, 2014
PURPOSE: To determine the sex and age-related effects of C1qa ablation on retinal ganglion cell (RGC) and optic nerve (ON) axonal loss in a mouse model of glaucomatous neurodegeneration.
A whole-blood RNA transcript-based prognostic model in men with castration-resistant prostate cancer: a prospective study.
Impact
Oh et al., Boston, United States. In Lancet Oncol, 2012
FINDINGS: A six-gene model (consisting of ABL2, SEMA4D, ITGAL, and C1QA, TIMP1, CDKN1A) separated patients with castration-resistant prostate cancer into two risk groups: a low-risk group with a median survival of more than 34·9 months (median survival was not reached) and a high-risk group with a median survival of 7·8 months (95% CI 1·8-13·9; p<0·0001).
DC-SIGN, C1q, and gC1qR form a trimolecular receptor complex on the surface of monocyte-derived immature dendritic cells.
GeneRIF
Ghebrehiwet et al., Stony Brook, United States. In Blood, 2012
C1q/gC1qR may regulate dendritic cells differentiation and function through the DC-SIGN-mediated induction of cell-signaling pathways.
Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes.
Impact
Komuro et al., Ōsaka, Japan. In Cell, 2012
Serum C1q concentration is increased with aging, and Wnt signaling activity is augmented during aging in the serum and in multiple tissues of wild-type mice, but not in those of C1qa-deficient mice.
The complement C1qA enhances retinoic acid-inducible gene-I-mediated immune signalling.
GeneRIF
Ye et al., Beijing, China. In Immunology, 2012
C1qA can counteract the function of the C1q receptor gC1qR in RIG-I-mediated signalling
Association study of C1qA polymorphisms with systemic lupus erythematosus in a Han population.
GeneRIF
Zeng et al., Beijing, China. In Lupus, 2012
The C1qA SNPs, rs172378 and rs665691, confer no genetic predisposition to systemic lupus erythematosus in a Chinese Han population
TRAF1/C5, eNOS, C1q, but not STAT4 and PTPN22 gene polymorphisms are associated with genetic susceptibility to systemic lupus erythematosus in Turkey.
GeneRIF
Goulielmos et al., Irákleion, Greece. In Hum Immunol, 2011
A genetic association of the TRAF1/C5, C1q, and eNOS gene polymorphism, but not of STAT4 and PTPN22, was found to confer a degree of risk for systemic lupus erythematosus in the Turkish population.
Interaction of HmC1q with leech microglial cells: involvement of C1qBP-related molecule in the induction of cell chemotaxis.
GeneRIF
Lefebvre et al., Villeneuve-d'Ascq, France. In J Neuroinflammation, 2011
This study demonstrated that rHmC1q-dependent chemotaxis might be driven via a HmC1q-binding protein located on the microglial cell surfac.
Immuno-modulatory gene polymorphisms and outcome in breast and ovarian cancer.
Review
DeMichele et al., Philadelphia, United States. In Immunol Invest, 2008
We have focused on those involved in the proinflammatory response (IL-6, TNF-alpha), apoptosis (TGF-beta, Fas, FasL, C1QA), angiogenesis (IL-8) and autoimmunity (IL-10).
Complement factors in adult peripheral nerve: a potential role in energy metabolism.
Review
Lemke et al., Los Angeles, United States. In Neurochem Int, 2004
Here we show that components of both the classical (C1qa, C1qb, C1qc, C2 and C4) and alternative (C3, B and adipsin) pathways are expressed by uninjured peripheral nerve as well.
Natural antibodies and complement are endogenous adjuvants for vaccine-induced CD8+ T-cell responses.
Impact
Kaye et al., London, United Kingdom. In Nat Med, 2003
Similarly, no IL-4 response or CD8(+) T-cell priming was seen in C1qa(-/-) mice.
Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies.
Impact
Walport et al., London, United Kingdom. In Nat Genet, 1998
C1q-deficient (C1qa-/-) mice were generated by gene targeting and monitored for eight months.
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