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CD93 molecule

C1q receptor, C1qR, C1qRp, CD93, C1qR(P)
The protein encoded by this gene is a cell-surface glycoprotein and type I membrane protein that was originally identified as a myeloid cell-specific marker. The encoded protein was once thought to be a receptor for C1q, but now is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells. The intracellular cytoplasmic tail of this protein has been found to interact with moesin, a protein known to play a role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, ACID, CD45
Papers on C1q receptor
LL-37-induced host cell cytotoxicity depends on cellular expression of the globular C1q receptor (p33).
Nilsson et al., Lund, Sweden. In Biochem J, Feb 2016
p33, also known as globular C1q receptor (gC1qR), is reported to act as an LL-37 antagonist by binding the peptide, thereby reducing its cytotoxic activity.
B-1 B cell progenitors transiently and partially express keratin 5 during differentiation in bone marrow.
Katayama et al., Suita, Japan. In J Dermatol Sci, Dec 2015
These cells were IgM(+)IgD(low)CD23(-)CD43(+)CD19(+)CD93(-), indicating that they were B-1 B cells.
Elevated Expression of the C-Type Lectin CD93 in the Glioblastoma Vasculature Regulates Cytoskeletal Rearrangements That Enhance Vessel Function and Reduce Host Survival.
Dimberg et al., Uppsala, Sweden. In Cancer Res, Dec 2015
Here, we report a novel role for CD93 in regulating angiogenesis in this setting by modulating cell-cell and cell-matrix adhesion of endothelial cells.
CD93 Marks a Non-Quiescent Human Leukemia Stem Cell Population and Is Required for Development of MLL-Rearranged Acute Myeloid Leukemia.
Cleary et al., Stanford, United States. In Cell Stem Cell, Nov 2015
Although human CD34(+)CD38(-) LSCs are generally highly quiescent, the C-type lectin CD93 is expressed on a subset of actively cycling, non-quiescent AML cells enriched for LSC activity.
CD93 gene polymorphism is associated with disseminated colorectal cancer.
Wågsäter et al., Linköping, Sweden. In Int J Colorectal Dis, Jul 2015
PURPOSE: Cluster of differentiation 93 (CD93) is involved in apoptosis and inflammation and has a suggested role in angiogenesis, and all of which are involved in the development and dissemination of cancer.
A quantitative assessment of the content of hematopoietic stem cells in mouse and human endosteal-bone marrow: a simple and rapid method for the isolation of mouse central bone marrow.
Muench et al., San Francisco, United States. In Bmc Hematol, 2014
Enzymatic digestion used to isolate eBM did, however, have a detrimental effect on detecting the expression of the human HSC-antigens CD4, CD90 and CD93, whereas CD34, CD38, CD133 and HLA-DR were unaffected.
cC1qR/CR and gC1qR/p33: observations in cancer.
Ghebrehiwet et al., New York City, United States. In Mol Immunol, 2014
It is not surprising therefore that blockade of C1qR on tumor cells inhibits their proliferation suggesting the significance of C1qRs in tumor growth and progression.
[Eenie, Meenie, Miney, Moe, who is responsible for the antibody-dependent enhancement of Aleutian mink disease parvovirus infection?].
Wen et al., In Bing Du Xue Bao, 2014
Three models have been proposed, including: (1) interactions between antibody and FcR, complement C3 fragment and CR, or between C1q and C1qR, which promotes viral attachment to cells; (2) suppression of IFN-gamma-mediated host-cell antiviral gene expression by the upregulation of negative regulators of pathogen pattern recognition; and (3) the promotion of early IL-10 secretion.
CD34(-) cells at the apex of the human hematopoietic stem cell hierarchy have distinctive cellular and molecular signatures.
Bonnet et al., United Kingdom. In Cell Stem Cell, 2013
Here, we show that the self-renewing Lin(-)CD34(-)CD38(-)CD93(hi) population contains cells that not only function as HSCs, but can also be placed above the CD34(+) populations in the hematopoietic hierarchy.
CD93: recent advances and implications in disease.
Bohlson et al., United States. In Curr Drug Targets, 2012
While it has been known for some time that CD93 regulates several processes involved in innate immunity and inflammation including phagocytosis and adhesion, the function of CD93 in disease progression is only now being elucidated.
Plasma CD93 concentration is a potential novel biomarker for coronary artery disease.
Hamsten et al., Stockholm, Sweden. In J Intern Med, 2011
Results suggest that the plasma concentration of soluble CD93 is a potential novel biomarker for Coronary Artery Disease (CAD), including MI.
Serine protease autotransporters from Shigella flexneri and pathogenic Escherichia coli target a broad range of leukocyte glycoproteins.
Nataro et al., Baltimore, United States. In Proc Natl Acad Sci U S A, 2011
Data show that Pic, a class 2 SPATE protein produced by Shigella flexneri 2a targets a broad range of human leukocyte glycoproteins including CD43, CD44, CD45, CD93, CD162 and the surface-attached chemokine fractalkine.
Flow cytometric identification of CD93 expression on naive T lymphocytes (CD4(+)CD45RA (+) cells) in human neonatal umbilical cord blood.
Inoko et al., Nobeoka, Japan. In J Clin Immunol, 2010
expression on naive T lymphocytes (CD4(+)CD45RA (+) cells) in human neonatal umbilical cord blood
Novel pathogenic mechanism and therapeutic approaches to angioedema associated with C1 inhibitor deficiency.
Tedesco et al., Trieste, Italy. In J Allergy Clin Immunol, 2009
both B1 receptor and gC1q receptor are involved in the vascular leakage induced by hereditary and acquired angioedema plasma.
Structure of the third intracellular loop of the vasopressin V2 receptor and conformational changes upon binding to gC1qR.
Déméné et al., Montpellier, France. In J Mol Biol, 2009
The authors observed that binding of gC1qR to the full-length receptor modifies the intrinsic tryptophan fluorescence binding curves of V2 to an antagonist.
CD93 and related family members: their role in innate immunity.
Bohlson et al., United States. In Curr Drug Targets, 2008
CD93 belongs to a newly described family of transmembrane glycoproteins which also includes endosialin and thrombomodulin.
The alpha2beta1 integrin: a novel collectin/C1q receptor.
Edelson et al., Nashville, United States. In Immunobiology, 2006
Our laboratory focuses on the alpha2beta1 integrin, a receptor for a number of matrix and non-matrix ligands, including collagens, laminins, decorin, E-cadherin, matrix metalloproteinase-1 (MMP-1), endorepellin, and several viruses.
Neuronal protection in stroke by an sLex-glycosylated complement inhibitory protein.
Pinsky et al., New York City, United States. In Science, 1999
Ischemic neurons strongly expressed C1q, which may target them for complement-mediated attack or C1qRp-mediated clearance.
Complement receptor type 1 (CR1, CD35) is a receptor for C1q.
Nicholson-Weller et al., Boston, United States. In Immunity, 1997
Thus, CR1 is a cellular C1q receptor that recognizes all three complement opsonins, namely, C1q, C3b, and C4b.
cDNA cloning and primary structure analysis of C1qR(P), the human C1q/MBL/SPA receptor that mediates enhanced phagocytosis in vitro.
Tenner et al., Irvine, United States. In Immunity, 1997
Monoclonal antibodies R3 and R139, which inhibit the enhancement triggered by these three ligands, were used to purify a 126,000 M(r) cell surface protein designated C1qR(P).
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