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V-yes-1 Yamaguchi sarcoma viral oncogene homolog 1

c-Yes, YES1
This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Src, alpha-Synuclein, CAN, Lyn, V1a
Papers on c-Yes
miR-17-5p up-regulates YES1 to modulate the cell cycle progression and apoptosis in ovarian cancer cell lines.
Tang et al., Tianjin, China. In J Cell Biochem, 05 Feb 2015
YES1 was identified as a novel target gene of miR-17-5p.
Identification of miR-145 targets through an integrated omics analysis.
Pandey et al., Baltimore, United States. In Mol Biosyst, Jan 2015
In our transcriptomic analysis, overexpression of miR-145 was found to suppress the expression of genes that are implicated in development of cancer such as ITGA11 and MAGEA4 in addition to previously described targets such as FSCN1, YES1 and PODXL.
Src-family tyrosine kinase activities are essential for differentiation of human embryonic stem cells.
Smithgall et al., Pittsburgh, United States. In Stem Cell Res, Nov 2014
Both Hck and c-Yes are important in self-renewal, while c-Src activity alone is sufficient to induce differentiation.
Differential effects of c-Src and c-Yes on the endocytic vesicle-mediated trafficking events at the Sertoli cell blood-testis barrier: an in vitro study.
Cheng et al., Hong Kong, Hong Kong. In Am J Physiol Endocrinol Metab, Nov 2014
We hypothesized that c-Src and c-Yes might work in contrasting roles in endocytic vesicle-mediated trafficking, serving as molecular switches, to effectively disassemble and reassemble the old and the new BTB, respectively, to facilitate preleptotene spermatocyte transport across the BTB.
Germ cell transport across the seminiferous epithelium during spermatogenesis.
Cheng et al., Hong Kong, Hong Kong. In Physiology (bethesda), Jul 2014
Signaling molecules, such as focal adhesion kinase, c-Yes, c-Src, and intercellular adhesion molecules 1 and 2, are involved in these events by regulating actin-based cytoskeleton via their action on actin-regulating proteins, endocytic vesicle-mediated protein trafficking, and adhesion protein complexes.
The inhibition of SRC family kinase suppresses pancreatic cancer cell proliferation, migration, and invasion.
Lee et al., South Korea. In Pancreas, Jul 2014
The SFK messenger RNA profiles showed that Yes1, Lyn, Fyn, Frk, Hck, and Src were expressed.
Role of non-receptor protein tyrosine kinases in spermatid transport during spermatogenesis.
Cheng et al., New York City, United States. In Semin Cell Dev Biol, Jun 2014
Herein, we focus on the role of non-receptor protein tyrosine kinases, most notably, FAK, c-Yes and c-Src, in the transport of spermatids across the seminiferous epithelium during spermatogenesis.
Colon cancer cells escape 5FU chemotherapy-induced cell death by entering stemness and quiescence associated with the c-Yes/YAP axis.
Huet et al., Saint-Pierre-des-Corps, France. In Clin Cancer Res, Mar 2014
These quiescent cells overexpressed the tyrosine kinase c-Yes that became activated and membrane-associated upon 5FU exposure.
Legality and age influence end of life decisions in Mexican physicians.
Lisker et al., In Rev Invest Clin, 2014
The response options to the PAD and WD questions included a conditioned yes (CYes) dealing with legalization of PAD or the existence of a patient's previous written agreement to WD. RESULTS: Beginners had significantly more Yes plus C-Yes answers than advanced for questions regarding PAD (82 vs. 55%), WD (95 vs. 75%) and PPAD (76 vs. 56%).
YES1 activation elicited by heat stress is anti-apoptotic in mouse pachytene spermatocytes.
Li et al., Xi'an, China. In Biol Reprod, 2013
Herein, YES1, a nonreceptor protein tyrosine kinase, was found to be significantly up-regulated in pachytene spermatocytes (PS) during early recovery from a transient testicular heat stress.
Cellular proteins associated with the interior and exterior of vesicular stomatitis virus virions.
Grdzelishvili et al., Charlotte, United States. In Plos One, 2013
Using western blotting, the presence of several host proteins, including some not previously shown in association with VSV (such as Yes1, Prl1 and Ddx3y), was confirmed and their relative quantities in various virion fractions determined.
β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis.
Hahn et al., Boston, United States. In Cell, 2013
Phosphorylation of YAP1 by the tyrosine kinase YES1 leads to localization of this complex to the promoters of antiapoptotic genes, including BCL2L1 and BIRC5.
LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma.
Sharpless et al., Chapel Hill, United States. In Cancer Cell, 2012
Results suggest that LKB1 inactivation in the context of RAS activation facilitates metastasis by inducing an SFK-dependent expansion of a prometastatic, CD24(+) tumor subpopulation.
The blood-testis barrier and its implications for male contraception.
Mruk et al., New York City, United States. In Pharmacol Rev, 2012
Studies have demonstrated that some unlikely partners, namely adhesion protein complexes (e.g., occludin-ZO-1, N-cadherin-β-catenin, claudin-5-ZO-1), steroids (e.g., testosterone, estradiol-17β), nonreceptor protein kinases (e.g., focal adhesion kinase, c-Src, c-Yes), polarity proteins (e.g., PAR6, Cdc42, 14-3-3), endocytic vesicle proteins (e.g., clathrin, caveolin, dynamin 2), and actin regulatory proteins (e.g., Eps8, Arp2/3 complex), are working together, apparently under the overall influence of cytokines (e.g., transforming growth factor-β3, tumor necrosis factor-α, interleukin-1α).
Functional activation of Src family kinase yes protein is essential for the enhanced malignant properties of human melanoma cells expressing ganglioside GD3.
Furukawa et al., United States. In J Biol Chem, 2011
Functional activation of Src family kinase yes protein is essential for the enhanced malignant properties of human melanoma cells expressing ganglioside GD3.
Regulation of mouse embryonic stem cell self-renewal by a Yes-YAP-TEAD2 signaling pathway downstream of LIF.
Annerén et al., Uppsala, Sweden. In J Cell Sci, 2011
YAP, TEAD2 and Yes are highly expressed in self-renewing embryonic stem cells, and are activated by LIF.
c-Yes regulates cell adhesion at the blood-testis barrier and the apical ectoplasmic specialization in the seminiferous epithelium of rat testes.
Cheng et al., New York City, United States. In Int J Biochem Cell Biol, 2011
c-Yes regulates blood-testis barrier and apical ectoplasmic specialization integrity by maintaining proper distribution of integral membrane proteins and actin filament organization at these sites
Specific oncogenic activity of the Src-family tyrosine kinase c-Yes in colon carcinoma cells.
Cruzalegui et al., Vitry-sur-Seine, France. In Plos One, 2010
c-Yes regulates specific oncogenic signalling pathways important for colon cancer progression that is not shared with c-Src.
c-Yes response to growth factor activation.
Flynn et al., Morgantown, United States. In Growth Factors, 2005
The most studied kinase of this nine member family, c-Src, shares a similar structure, as well as a similar expression pattern to that of another Src family protein, c-Yes.
Specificity in signaling by c-Yes.
Flynn et al., Morgantown, United States. In Front Biosci, 2003
This review summarizes the potential functions of c-Yes and its ability to modulate signals that are distinct from c-Src.
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