C-type lectin-like receptor
Targeting platelet receptors in thrombotic and thrombo-inflammatory disorders.
Würzburg, Germany. In Hamostaseologie, 2014
This review summarizes recent developments in understanding the function of glycoprotein (GP)Ib, GPVI and the C-type lectin-like receptor 2 (CLEC-2) in hemostasis, arterial thrombosis and thrombo-inflammation and will discuss the suitability of the receptors as novel targets to treat these diseases in humans.
Platelet ITAM signaling.
Chapel Hill, United States. In Curr Opin Hematol, 2013
In contrast, deficiency in the immunoreceptor tyrosine-based activation motif (ITAM)-coupled receptors glycoprotein (GP)VI or C-type lectin-like receptor (CLEC)-2 is associated with only a mild bleeding diathesis in humans and mice.