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Centrosomal protein 250kDa

C-Nap1, hCAP-D2, CAPD2, NCAPD2, Cep250
This gene encodes a core centrosomal protein required for centriole-centriole cohesion during interphase of the cell cycle. The encoded protein dissociates from the centrosomes when parental centrioles separate at the beginning of mitosis. The protein associates with and is phosphorylated by NIMA-related kinase 2, which is also associated with the centrosome. [provided by RefSeq, Jun 2009] (from NCBI)
Top mentioned proteins: CAN, MUC4, HAD, PP1, Eg5
Papers on C-Nap1
Injury-induced inflammation and inadequate HSP expression in mesothelial cells upon repeat exposure to dual-chamber bag peritoneal dialysis fluids.
New
Aufricht et al., Berlin, Germany. In Int J Artif Organs, Dec 2015
METHODS: Primary cultures of human peritoneal mesothelial cells (HPMC) were exposed to a 1:2 mixture of cell culture medium and CAPD2 (single-chamber bag PDF; Fresenius, Bad Homburg, Germany), Physioneal (dual-chamber bag PDF; Baxter, Deerfield, IL, USA) or Balance (dual-chamber bag PDF, Fresenius) for up to 10 days exposure time (4 dwells).
Rootletin organizes the ciliary rootlet to achieve neuron sensory function in Drosophila.
New
Megraw et al., Portugal. In J Cell Biol, Nov 2015
Here we report that Drosophila melanogaster Rootletin (Root), the sole orthologue of the mammalian paralogs Rootletin and C-Nap1, assembles into rootlets of diverse lengths among sensory neuron subtypes.
The centrosomal linker and microtubules provide dual levels of spatial coordination of centrosomes.
New
Schiebel et al., Heidelberg, Germany. In Plos Genet, May 2015
This centrosomal linker is composed of rootletin filaments that are anchored to the centrioles via the protein C-Nap1.
The tumor suppressor proteins ASPP1 and ASPP2 interact with C-Nap1 and regulate centrosome linker reassembly.
New
Yu et al., Shanghai, China. In Biochem Biophys Res Commun, Apr 2015
We showed that ASPP1/2 interacted with centrosome linker protein C-Nap1.
Cep68 can be regulated by Nek2 and SCF complex.
New
Lim et al., Singapore, Singapore. In Eur J Cell Biol, Mar 2015
Cohesion is regulated by the antagonistic activities of the mitotic NIMA-related kinase 2 (Nek2), protein phosphatase 1, the cohesion fiber components rootletin, centrosomal Nek2-associated protein 1 (C-Nap1) and Cep68.
A novel bipartite centrosome coordinates the apicomplexan cell cycle.
New
White et al., Athens, United States. In Plos Biol, Mar 2015
An outer core complex distal from the nucleus contains the TgCentrin1/TgSfi1 protein pair, along with the cartwheel protein TgSas-6 and a novel Aurora-related kinase, while an inner core closely aligned with the unique spindle pole (centrocone) holds distant orthologs of the CEP250/C-Nap protein family.
C-Nap1 mutation affects centriole cohesion and is associated with a Seckel-like syndrome in cattle.
Schibler et al., Jouy-le-Moutier, France. In Nat Commun, 2014
Here we show that SHGC is caused by a truncating mutation in the CEP250 gene that encodes the centrosomal protein C-Nap1.
TEIF associated centrosome activity is regulated by EGF/PI3K/Akt signaling.
Zhang et al., Beijing, China. In Biochim Biophys Acta, 2014
Moreover, TEIF closely co-localized with C-NAP1 at the proximal ends of centrioles, and centriolar loading of TEIF stimulated by EGF/Akt could displace C-NAP1, resulting in centrosome splitting.
A homozygous nonsense CEP250 mutation combined with a heterozygous nonsense C2orf71 mutation is associated with atypical Usher syndrome.
Sharon et al., Jerusalem, Israel. In J Med Genet, 2014
RESULTS: A combination of homozygosity mapping and WES in a large consanguineous family of Iranian Jewish origin revealed nonsense mutations in two ciliary genes: c.3289C>T (p.Q1097*) in C2orf71 and c.3463C>T (p.R1155*) in centrosome-associated protein CEP250 (C-Nap1).
Multisite phosphorylation of C-Nap1 releases it from Cep135 to trigger centrosome disjunction.
Fry et al., Seoul, South Korea. In J Cell Sci, 2014
However, interphase centrosomes are physically tethered by a proteinaceous linker composed of C-Nap1 (also known as CEP250) and the filamentous protein rootletin.
Non-SMC condensin I complex, subunit D2 gene polymorphisms are associated with Parkinson's disease: a Han Chinese study.
Wang et al., Wuhan, China. In Genome, 2014
Previous studies have indicated that non-SMC condensin I complex, subunit D2 (NCAPD2), an important protein in chromosome condensation, gene polymorphisms are associated with Alzheimer's disease.
CEP proteins: the knights of centrosome dynasty.
Review
Purohit et al., Vellore, India. In Protoplasma, 2013
Moreover, CEP27, CEP55, CEP70, CEP110, CEP120, CEP135, CEP192, CEP250, CEP290, and CEP350 also seem promising for future drug discovery approaches.
Condensin I recruitment to base damage-enriched DNA lesions is modulated by PARP1.
GeneRIF
Yokomori et al., Irvine, United States. In Plos One, 2010
Data show that that DNA repear process is dictated by PARP1 through its interaction with the chromosome-targeting domain of the hCAP-D2 subunit of condensin I.
Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction.
Impact
Schiebel et al., Heidelberg, Germany. In Nat Cell Biol, 2010
The NIMA (never in mitosis A)-related kinase Nek2A is implicated in disconnecting the centrosomes through disjoining the linker proteins C-Nap1 and rootletin.
SIK2 is a centrosome kinase required for bipolar mitotic spindle formation that provides a potential target for therapy in ovarian cancer.
Impact
Bast et al., Houston, United States. In Cancer Cell, 2010
Here, we show that the salt inducible kinase 2 (SIK2) localizes at the centrosome, plays a key role in the initiation of mitosis, and regulates the localization of the centrosome linker protein, C-Nap1, through S2392 phosphorylation.
A centrosome kinase modulates antitumor drug sensitivity.
Impact
Salisbury, Rochester, United States. In Cancer Cell, 2010
In this issue of Cancer Cell, Ahmed and coworkers identify SIK2 as a centrosome kinase and show that it controls the localization of the centriole linker protein C-Nap1.
A novel function of CEP135 as a platform protein of C-NAP1 for its centriolar localization.
GeneRIF
Rhee et al., Seoul, South Korea. In Exp Cell Res, 2009
CEP135 acts as a platform protein for C-NAP1 at the centriole.
Characterization of the condensin component Cnap1 and protein kinase Melk as novel E2F target genes down-regulated by 1,25-dihydroxyvitamin D3.
GeneRIF
Verstuyf et al., Leuven, Belgium. In J Biol Chem, 2005
The characterization of two novel E2F target genes, chromosome condensation-related SMC-associated protein 1 (Cnap1) and maternal embryonic leucine zipper kinase (Melk) is reported.
The mechanism regulating the dissociation of the centrosomal protein C-Nap1 from mitotic spindle poles.
GeneRIF
Nigg et al., Martinsried, Germany. In J Cell Sci, 2002
Data show that the dissociation of C-Nap1 from mitotic centrosomes is regulated by localized phosphorylation rather than generalized proteolysis.
Identification of a chromosome-targeting domain in the human condensin subunit CNAP1/hCAP-D2/Eg7.
GeneRIF
Yokomori et al., Irvine, United States. In Mol Cell Biol, 2002
Data show the CNAP1 C-terminal region defines a novel histone-binding domain that is responsible for targeting CNAP1, and possibly condensin, to mitotic chromosomes.
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