The transcription factor STAT2 enhances proteasomal degradation of RCAN1 through the ubiquitin E3 ligase FBW7more suppliers
In PLoS ONE, 2011
... The HA, GFP, GST, Hsp90, ubiquitin, α-tubulin, histone H1, and Myc antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Myc mouse and anti-ageing therapy.
London, United Kingdom. In Trends Endocrinol Metab, 26 Mar 2015
UNASSIGNED: Reduction in the expression and activity of a well-known proto-oncogene, Myc, has a beneficial effect on mouse health and survival to old age, in part independently of cancer impact, a recent study reveals.
Emerging concepts in bioenergetics and cancer research: Metabolic flexibility, coupling, symbiosis, switch, oxidative tumors, metabolic remodeling, signaling and bioenergetic therapy.
Bordeaux, France. In Int J Biochem Cell Biol, Jan 2015
A clearer understanding of the large-scale bioenergetic impact of C-MYC, MYCN, KRAS and P53 was obtained, along with its modification during the course of tumor development.
Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor.
Boston, United States. In Cancer Cell, Jan 2015
Using a high-throughput cellular screen of a diverse chemical library, we observe that SCLC is sensitive to transcription-targeting drugs, in particular to THZ1, a recently identified covalent inhibitor of cyclin-dependent kinase 7. We find that expression of super-enhancer-associated transcription factor genes, including MYC family proto-oncogenes and neuroendocrine lineage-specific factors, is highly vulnerability to THZ1 treatment.
Molecular mechanisms of induced pluripotency.
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Poznań, Poland. In Contemp Oncol (pozn), Dec 2014
Overexpression of just four pluripotency-related transcription factors, namely Oct3/4, Sox2, Klf4, and c-Myc (Yamanaka factors, OKSM), in fibroblasts appears sufficient to produce this new cell type.
Discovery of a novel proteasome inhibitor selective for cancer cells over non-transformed cells
In Cell death and differentiation, 2008
... MA), mTOR (Millipore, Temecula, CA), E-cadherin (BD Biosciences, San José, CA), GAPDH (Covance, Princeton, NJ), Myc monoclonal antibody 9E10 (Santa Cruz Biotechnology, Santa Cruz, CA), AlexaFluor594 ... Colocalization
In Neural Development, 2007
... II site of pCMV-Myc (Clontech, Mountain View, California, USA) ... A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol
In The Journal of Cell Biology, 2003
... MA), epoxomicin (Enzo Life Sciences, Inc.), diamide (TCI America), rat anti-HA antibody (3F10; Roche), mouse anti-Myc antibody (9E10; Roche), rabbit antiubiquitin antibody (Enzo Life Sciences, Inc.), rabbit anticalnexin antibody (Abcam), rabbit antigigantin antibody (Abcam), ... Sequence selective double strand DNA cleavage by peptide nucleic acid (PNA) targeting using nuclease S1
In PLoS ONE, 1992
... ; immunocytochemistry [ICC], 1/100 dilution; western blot [WB], 1/5000 dilution), rabbit anti-Myc (A14; Santa Cruz Biotech, Heidelberg, Germany; ICC, 1/100), rabbit anti-GCL (Santa Cruz Biotech; WB, 1/1000), rabbit anti-GCL (Sigma Aldrich, Brondby, Denmark; WB, 1/1000), ...