The transcription factor STAT2 enhances proteasomal degradation of RCAN1 through the ubiquitin E3 ligase FBW7more suppliers
In PLoS ONE, 2011
... The HA, GFP, GST, Hsp90, ubiquitin, α-tubulin, histone H1, and Myc antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
GUGGULSTERONE FOR CHEMOPREVENTION OF CANCER.
Houston, United States. In Curr Pharm Des, 12 Dec 2015
Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP, and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases, inhibition of Akt, and activation of JNK.
Constitutive activation of STAT3 in breast cancer cells: A review.
Pullman, United States. In Int J Cancer, 11 Dec 2015
Aberrant STAT3 signaling promotes breast tumor progression through deregulation of the expression of downstream target genes which control proliferation (Bcl-2, Bcl-xL, Survivin, Cyclin D1, c-Myc, Mcl-1), angiogenesis (Hif1α, VEGF), and epithelial-mesenchymal transition (Vimentin, TWIST, MMP-9, MMP-7).
Splicing and Dicing MYC-Mediated Synthetic Lethality.
Philadelphia, United States. In Cancer Cell, 12 Nov 2015
In a recent issue of Nature, Hsu and colleagues report that oncogenic MYC activation is synthetic lethal with inhibition of the core spliceosome, because MYC-driven growth and increased transcription leave tumors dependent on pre-mRNA processing for survival.
The Emerging Roles of F-box Proteins in Pancreatic Tumorigenesis.
More papers using
Houston, United States. In Semin Cancer Biol, 15 Oct 2015
We will highlight the functions and regulation of these F-box proteins, their respective substrates and cross-talks with other key signaling pathways, such as the Ras-Raf-Mek-Erk, Hedgehog, NFκB, TGF-β, Myc and HPK1 signaling pathways etc. in pancreatic cancer.
Discovery of a novel proteasome inhibitor selective for cancer cells over non-transformed cells
In Cell death and differentiation, 2008
... MA), mTOR (Millipore, Temecula, CA), E-cadherin (BD Biosciences, San José, CA), GAPDH (Covance, Princeton, NJ), Myc monoclonal antibody 9E10 (Santa Cruz Biotechnology, Santa Cruz, CA), AlexaFluor594 ... Colocalization
In Neural Development, 2007
... II site of pCMV-Myc (Clontech, Mountain View, California, USA) ... A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol
In The Journal of Cell Biology, 2003
... MA), epoxomicin (Enzo Life Sciences, Inc.), diamide (TCI America), rat anti-HA antibody (3F10; Roche), mouse anti-Myc antibody (9E10; Roche), rabbit antiubiquitin antibody (Enzo Life Sciences, Inc.), rabbit anticalnexin antibody (Abcam), rabbit antigigantin antibody (Abcam), ... Sequence selective double strand DNA cleavage by peptide nucleic acid (PNA) targeting using nuclease S1
In PLoS ONE, 1992
... ; immunocytochemistry [ICC], 1/100 dilution; western blot [WB], 1/5000 dilution), rabbit anti-Myc (A14; Santa Cruz Biotech, Heidelberg, Germany; ICC, 1/100), rabbit anti-GCL (Santa Cruz Biotech; WB, 1/1000), rabbit anti-GCL (Sigma Aldrich, Brondby, Denmark; WB, 1/1000), ...