The transcription factor STAT2 enhances proteasomal degradation of RCAN1 through the ubiquitin E3 ligase FBW7more suppliers
In PLoS ONE, 2011
... The HA, GFP, GST, Hsp90, ubiquitin, α-tubulin, histone H1, and Myc antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
The MYC-WDR5 Nexus and Cancer.
Nashville, United States. In Cancer Res, 01 Nov 2015
The MYC oncogenes encode a family of transcription factors that feature prominently in cancer.
MYC, Metabolism, and Cancer.
Philadelphia, United States. In Cancer Discov, 31 Oct 2015
UNLABELLED: The MYC oncogene encodes a transcription factor, MYC, whose broad effects make its precise oncogenic role enigmatically elusive.
MYC: connecting selective transcriptional control to global RNA production.
Milano, Italy. In Nat Rev Cancer, 31 Oct 2015
Two opposing models have been proposed to describe the function of the MYC oncoprotein in shaping cellular transcriptomes: one posits that MYC amplifies transcription at all active loci; the other that MYC differentially controls discrete sets of genes, the products of which affect global transcript levels.
MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells.
Philadelphia, United States. In Cell Metab, 16 Oct 2015
UNASSIGNED: The MYC oncogene encodes MYC, a transcription factor that binds the genome through sites termed E-boxes (5'-CACGTG-3'), which are identical to the binding sites of the heterodimeric CLOCK-BMAL1 master circadian transcription factor.
SjCa8, a calcium-binding protein from Schistosoma japonicum, inhibits cell migration and suppresses nitric oxide release of RAW264.7 macrophages.
Guangzhou, China. In Parasit Vectors, Dec 2014
Additionally, rSjCa8 potently inhibited NO release by LPS-stimulated macrophages in a dose- and time-dependent manner, and the inhibitory mechanism was closely associated with intracellular Ca(2+) levels, the up-regulation of catalase expression, and the down-regulation of the expression of 47 genes, including Myc, Gadd45a, Txnip, Fas, Sod2, Nos2, and Hmgb1.
Genome-editing tools for stem cell biology.
More papers using
Saint Petersburg, Russia. In Cell Death Dis, Dec 2014
That the expression of only four transcription factors, Oct4, Klf4, Sox2 and c-Myc (OKSM), is sufficient for generation of induced pluripotent stem cells (iPSCs) from differentiated somatic cells has revolutionized the field and also highlighted the importance of OKSM as targets for genome editing.
Discovery of a novel proteasome inhibitor selective for cancer cells over non-transformed cells
In Cell death and differentiation, 2008
... MA), mTOR (Millipore, Temecula, CA), E-cadherin (BD Biosciences, San José, CA), GAPDH (Covance, Princeton, NJ), Myc monoclonal antibody 9E10 (Santa Cruz Biotechnology, Santa Cruz, CA), AlexaFluor594 ... Colocalization
In Neural Development, 2007
... II site of pCMV-Myc (Clontech, Mountain View, California, USA) ... A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol
In The Journal of Cell Biology, 2003
... MA), epoxomicin (Enzo Life Sciences, Inc.), diamide (TCI America), rat anti-HA antibody (3F10; Roche), mouse anti-Myc antibody (9E10; Roche), rabbit antiubiquitin antibody (Enzo Life Sciences, Inc.), rabbit anticalnexin antibody (Abcam), rabbit antigigantin antibody (Abcam), ... Sequence selective double strand DNA cleavage by peptide nucleic acid (PNA) targeting using nuclease S1
In PLoS ONE, 1992
... ; immunocytochemistry [ICC], 1/100 dilution; western blot [WB], 1/5000 dilution), rabbit anti-Myc (A14; Santa Cruz Biotech, Heidelberg, Germany; ICC, 1/100), rabbit anti-GCL (Santa Cruz Biotech; WB, 1/1000), rabbit anti-GCL (Sigma Aldrich, Brondby, Denmark; WB, 1/1000), ...