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V-myc myelocytomatosis viral oncogene homolog

c-Myc, Myc
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, p53, PCNA, HAD
Papers using c-Myc antibodies
The transcription factor STAT2 enhances proteasomal degradation of RCAN1 through the ubiquitin E3 ligase FBW7
Hofmann Thomas G., In PLoS ONE, 2011
... The HA, GFP, GST, Hsp90, ubiquitin, α-tubulin, histone H1, and Myc antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Understanding morphogenetic growth control – lessons from flies
Guerrero-Hernandez Agustin, In PLoS ONE, 2010
... Myc-TβRII-GFP was generated by inserting the myc-TβRII sequence [43] into the pEGFP-N1 vector (Clontech).
Pre-B-cell leukemias in Btk/Slp65-deficient mice arise independently of ongoing V(D)J recombination activity.
Bunce Christopher, In PLoS ONE, 2010
... EμMyc transgenic mice were purchased from ...
The adaptor function of TRAPPC2 in mammalian TRAPPs explains TRAPPC2-associated SEDT and TRAPPC9-associated congenital intellectual disability.
Hong Wanjin, In PLoS ONE, 2010
... cDNAs encoding mammalian TRAPP subunits were amplified by PCR and subcloned into pCMV-Myc (Clontech) or peGFP-Cx vector (Clontech) ...
Galectin-3 mediates cross-talk between K-Ras and Let-7c tumor supressor micro RNA
Sarkar Fazlul H., In PLoS ONE, 2010
... Anti-cyclin D1 and anti- C-MYC antibody was from Santa Cruz Biotechnology, Inc ...
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Papers on c-Myc
Apogossypolone induces reactive oxygen species accumulation and controls cell cycle progression in Raji Burkkit's lymphoma cells.
Sun et al., Guangzhou, China. In Mol Med Report, 03 Apr 2015
The expression levels of the translocated cellular Myc (c‑Myc) oncogene and Epstein‑Barr virus infection have an oncogenic role in facilitating tumor progression and maintaining a malignant phenotype in BL Raji cells.
Perturbation of the c-Myc-Max Protein-Protein Interaction via Synthetic α-Helix Mimetics.
Fletcher et al., In J Med Chem, 03 Apr 2015
UNASSIGNED: The rational design of inhibitors of the bHLH-ZIP oncoprotein c-Myc is hampered by a lack of structure in its monomeric state.
p53, a translational regulator: contribution to its tumour-suppressor activity.
Diaz et al., Lyon, France. In Oncogene, 02 Apr 2015
Moreover, restricting the rate of protein synthesis has been shown to delays tumourigenesis in C-Myc overexpressing or PTEN deleted mice models.
Myc mouse and anti-ageing therapy.
Partridge et al., London, United Kingdom. In Trends Endocrinol Metab, 26 Mar 2015
UNASSIGNED: Reduction in the expression and activity of a well-known proto-oncogene, Myc, has a beneficial effect on mouse health and survival to old age, in part independently of cancer impact, a recent study reveals.
Cancer cell-associated cytoplasmic B7-H4 is induced by hypoxia through hypoxia-inducible factor-1α and promotes cancer cell proliferation.
Choi et al., Pusan, South Korea. In Biochem Biophys Res Commun, 25 Mar 2015
Finally, MMGP analysis revealed a positive correlation between the transcript levels of B7-H4 and proliferation-related genes including MKI67, CCNA1, and Myc in several patients with multiple myeloma.
Mechanism of action and therapeutic efficacy of Aurora kinase B inhibition in MYC overexpressing medulloblastoma.
Rutka et al., Toronto, Canada. In Oncotarget, 20 Mar 2015
UNASSIGNED: Medulloblastoma comprises four molecular subgroups of which Group 3 medulloblastoma is characterized by MYC amplification and MYC overexpression.
Reduced Expression of MYC Increases Longevity and Enhances Healthspan.
Sedivy et al., Providence, United States. In Cell, 01 Mar 2015
MYC is a highly pleiotropic transcription factor whose deregulation promotes cancer.
Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism.
Ma et al., Wuhan, China. In Nat Genet, 28 Feb 2015
Protein expression from MYC and HMGA2 was elevated when HPV integrated into flanking regions.
A Critical Role for Transcription Factor Smad4 in T Cell Function that Is Independent of Transforming Growth Factor β Receptor Signaling.
Wan et al., Chapel Hill, United States. In Immunity, 20 Feb 2015
The transcription factor Myc was identified to mediate Smad4-controlled T cell proliferation.
Polycomb genes, miRNA, and their deregulation in B-cell malignancies.
Tao et al., Chapel Hill, United States. In Blood, 07 Feb 2015
PcG hyperactivity in B cell lymphomas is caused by over-expression or recurrent mutations of PcG genes, and deregulation of microRNAs or transcription factors such asc-MYC, which regulate PcG expression.
The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling.
Giancotti et al., New York City, United States. In Nat Cell Biol, Jan 2015
Depletion of Rnd1 disrupted epithelial adhesion and polarity, induced epithelial-to-mesenchymal transition, and cooperated with deregulated expression of c-Myc or loss of p53 to cause neoplastic conversion.
Emerging concepts in bioenergetics and cancer research: Metabolic flexibility, coupling, symbiosis, switch, oxidative tumors, metabolic remodeling, signaling and bioenergetic therapy.
Rossignol et al., Bordeaux, France. In Int J Biochem Cell Biol, Jan 2015
A clearer understanding of the large-scale bioenergetic impact of C-MYC, MYCN, KRAS and P53 was obtained, along with its modification during the course of tumor development.
Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor.
Wong et al., Boston, United States. In Cancer Cell, Jan 2015
Using a high-throughput cellular screen of a diverse chemical library, we observe that SCLC is sensitive to transcription-targeting drugs, in particular to THZ1, a recently identified covalent inhibitor of cyclin-dependent kinase 7. We find that expression of super-enhancer-associated transcription factor genes, including MYC family proto-oncogenes and neuroendocrine lineage-specific factors, is highly vulnerability to THZ1 treatment.
Molecular mechanisms of induced pluripotency.
Jaworski et al., Poznań, Poland. In Contemp Oncol (pozn), Dec 2014
Overexpression of just four pluripotency-related transcription factors, namely Oct3/4, Sox2, Klf4, and c-Myc (Yamanaka factors, OKSM), in fibroblasts appears sufficient to produce this new cell type.
MYC-xing it up with PIK3CA mutation and resistance to PI3K inhibitors: summit of two giants in breast cancers.
De et al., Sioux Falls, United States. In Am J Cancer Res, Dec 2014
MYC elevation represents one of the potential modes of actions by which breast tumors develop resistance to the PI3K pathway-specific targeted therapies.
Prognostic relevance of c-Myc and BMI1 expression in patients with glioblastoma.
Larocca et al., Roma, Italy. In Am J Clin Pathol, 2012
We found that overexpression of c-Myc was significantly associated with that of BMI1, and that patients who harbored glioblastomas overexpressing c-Myc and BMI1 showed significantly longer overall survival.
Oncogenic Myc translocations are independent of chromosomal location and orientation of the immunoglobulin heavy chain locus.
Dunnick et al., Ann Arbor, United States. In Proc Natl Acad Sci U S A, 2012
Myc translocations are independent of chromosomal location and orientation of the immunoglobulin heavy chain locus
Synergy between PI3K signaling and MYC in Burkitt lymphomagenesis.
Rajewsky et al., Boston, United States. In Cancer Cell, 2012
Deregulated c-MYC and PI3K activity cooperate in Burkitt lymphoma pathogenesis.
Tristetraprolin impairs myc-induced lymphoma and abolishes the malignant state.
Cleveland et al., Jupiter, United States. In Cell, 2012
TTP suppression is a hallmark of cancers with MYC involvement, and restoring TTP impairs Myc-induced lymphomagenesis and abolishes maintenance of the malignant state.
Familial cortical myoclonus with a mutation in NOL3.
Ptáček et al., San Francisco, United States. In Ann Neurol, 2012
This study utilized unbiased, genome-wide approaches to identify a NOL3 mutation that likely causes Familial cortical myoclonus.
More papers using c-Myc antibodies
Oncogenic potential of retinoic acid receptor-gamma in hepatocellular carcinoma.
Lobaccaro Jean-Marc A., In PLoS ONE, 2009
... RXRα (ΔN197), AKT1/2/3 (H-136), Cyclin D1 (H-295), and monoclonal antibodies against Bax (6A7), GFP (B-2), c-Myc (9E10), GFP- and FITC-labeled anti-rabbit IgG were from Santa Cruz Biotechnology.
Nmnat2 delays axon degeneration in superior cervical ganglia dependent on its NAD synthesis activity.
Laudet Vincent, In PLoS ONE, 2009
... Shin-ichiro Imai, Washington University School of Medicine) was subcloned into pCMV-Myc vector (Clontech).
Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stress
Huang Tony T. et al., In The Journal of Cell Biology, 2009
... PBS, blocked in 1% BSA in TBS–Tween 20, and incubated with mouse anti-GFP and rabbit anti-Myc antibodies (Santa Cruz Biotechnology, Inc.) ...
Somatic single hits inactivate the X-linked tumor suppressor FOXP3 in the prostate.
Westermark Per, In PLoS ONE, 2008
... Hemizygous Lo-MYC mice on FVB background were cross-bred with non-transgenic FVB breeders ...
Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction
Kyprianou Natasha, In PLoS ONE, 2008
... Mouse monoclonal antibodies: β-TrCP, Skp2, and Fbw7, Invitrogen (Carlsbad, CA); Myc, Cell Signaling Technology (Beverly, MA); Cdh1, ...
Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation
Ip Y. Tony et al., In The Journal of Cell Biology, 2008
... Myc RNAi lines were obtained from VDRC, and the Transgenic RNAi Project, UAS-Myc, and ...
Discovery of a novel proteasome inhibitor selective for cancer cells over non-transformed cells
Sebti Saïd M. et al., In Cell death and differentiation, 2008
... MA), mTOR (Millipore, Temecula, CA), E-cadherin (BD Biosciences, San José, CA), GAPDH (Covance, Princeton, NJ), Myc monoclonal antibody 9E10 (Santa Cruz Biotechnology, Santa Cruz, CA), AlexaFluor594 ...
Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation.
Li Xiao-Jiang, In PLoS ONE, 2008
... Myc-tag antibody was purchased from Cell Signaling.
Bioimage informatics for experimental biology.
Hawley R. Scott, In PLoS Biology, 2008
... DB-MYC transgenic flies were generated by ...
Gene expression signatures diagnose influenza and other symptomatic respiratory viral infections in humans
Huang Erich et al., In BMC Medical Genomics, 2008
... levels of Myc mRNA transcript in the peripheral blood were measured by quantitative RT-PCR in MMTV/c-myc mice of each of the five transgenic lines derived by Eran ...
Stabilization of β-catenin induces pancreas tumor formation
Fontana Joseph A. et al., In Journal of Oncology, 2007
... Antibodies and their sources were as follows: antibodies for flow cytometry, CD44-PE, CD24-FITC, anti-EpCAM-PerCP-Cy5.5, and anti-c-Myc antibody from BD Biosciences (San Jose, CA) and ...
García-Añoveros Jaime et al., In Neural Development, 2007
... II site of pCMV-Myc (Clontech, Mountain View, California, USA) ...
Typical progression of myoclonic epilepsy of the Lafora type: a case report
Fischbeck K. H. et al., In Neurogenetics, 2007
... of laforin, the monoclonal ANTI-FLAG M2 antibody (Sigma) was used, while malin was detected using Myc-Tag Mouse mAb (Cell Signaling); both were diluted 1,000-fold ...
Inhibition of p73 function by Pifithrin-alpha as revealed by studies in zebrafish embryos.
Ouchi Toru, In PLoS ONE, 2007
... Anti β-Actin, anti-GFP, anti-Laminin A/C, anti-Myc, and anti-HA antibodies were purchased from Santa Cruz Biotechnology.
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization.
Ojcius David M., In PLoS ONE, 2007
... Murine caspase-1 p10 (M-20) and c-Myc (9E10) antibodies were obtained from Santa Cruz Biotechnology.
Dynamic behavior of Salmonella-induced membrane tubules in epithelial cells.
Abu Kwaik Yousef, In PLoS ONE, 2007
... Primary antibodies, mouse monoclonal antibodies to Myc and horseradish peroxidase (HRP)-conjugated secondary antibodies were obtained from Cell Signaling Technology unless otherwise noted ...
From endoplasmic-reticulum stress to the inflammatory response
Wu Jianqing et al., In Journal of Experimental & Clinical Cancer Research : CR, 2007
... The MYC-tagged klotho expression vector (pCMV6-MYC-KL) and its entry vector (pCMV6) were designed and purchased from OriGene (Rockville, MD, USA) ...
The outer segment serves as a default destination for the trafficking of membrane proteins in photoreceptors
Arshavsky Vadim Y. et al., In The Journal of Cell Biology, 2006
... were amplified from a mouse brain cDNA library (Stratagene); the Myc epitope was constructed from the pCMV-Myc vector (BD Biosciences); the CMV promoter was ...
Regulation of function by dimerization through the amino-terminal membrane-spanning domain of human ABCC1/MRP1.
Xu Wenqing, In PLoS ONE, 2006
... Monoclonal antibody BXP-21 against ABCG2, anti-Myc and anti-HA antibodies were from ID Labs, Cell Signaling, and Roche, respectively ...
Induced pluripotent stem cell lines derived from human somatic cells
Kasahara Noriyuki et al., In Molecular Therapy. Nucleic Acids, 2006
... Primary antibodies used were GKLF (sc-20691; Santa Cruz Biotechnology, Santa Cruz, CA) and c-Myc (sc-764; Santa Cruz Biotechnology).
A protocol for rapid generation of recombinant adenoviruses using the AdEasy system
Liu Wenjun et al., In Virology Journal, 2006
... C-Myc (9E10) antibodies were purchased from Santa Cruz Biotechnology.
SOCS proteins, cytokine signalling and immune regulation
Simas J Pedro et al., In The EMBO Journal, 2006
... was amplified by PCR from MuHV-4 genome, and the respective PCR product was cloned into pCMV-Myc (Clontech).
Regulation of EphA2 receptor endocytosis by SHIP2 lipid phosphatase via phosphatidylinositol 3-Kinase-dependent Rac1 activation
Katoh Hironori et al., In The Journal of Cell Biology, 2006
... EphA2 (D7) and cortactin (4F11; Millipore); a rat mAb against HA (3F10; Roche); a rabbit pAb against Myc (MBL); a goat pAb against ELMO2 ...
The human sef-a isoform utilizes different mechanisms to regulate receptor tyrosine kinase signalling pathways and subsequent cell fate
Gnanapragasam V J et al., In British Journal of Cancer, 2005
... DU145 cells were seeded into 90 mm tissue culture dishes and transfected with pCDNA3.1-Sef-Myc
P[acman]: a BAC transgenic platform for targeted insertion of large DNA fragments in D. melanogaster.
Kretzschmar Doris, In PLoS ONE, 2005
... , R4-eGFP-R3 L3-eGFP-Myc-L2, L1-eGFP-T-R5, L5-eGFP-T-L4, and R4-eGFP-T-R3⇒pEGFP (Clontech Cat# 6077-1), R4-mCherry-R3, L3-mCherry-HA-L2, ...
Regulation of Rap1 activity by RapGAP1 controls cell adhesion at the front of chemotaxing cells
Firtel Richard A. et al., In The Journal of Cell Biology, 2005
... We obtained LatA, LY294002, and phalloidin from Sigma-Aldrich, anti-Myc antibodies from Santa Cruz Biotechnology, Inc., monoclonal anti–pan-Ras (Ab-3) ...
Protein interacting with C-kinase 1/protein kinase Calpha-mediated endocytosis converts netrin-1-mediated repulsion to attraction.
Kira Jun-ichi, In PLoS ONE, 2005
... The following primary antibodies were used in this study: Myc-tag (1∶1,000; Santa Cruz Biotechnology, Santa Cruz, CA) and ...
Toward the active conformation of insulin: stereospecific modulation of a structural switch in the B chain.
von Herrath Matthias G., In PLoS ONE, 2005
... (#RI-13K), human insulin-specific radioimmunoassay (#HI-14K) and human proinsulin specific radioimmunoassay (#HPI-15K) were from Millipore; rabbit anti-Myc antibody was from Immunology Consultants Labs; Zysorbin was from ...
Nucleolar trafficking is essential for nuclear export of intronless herpesvirus mRNA.
Glaunsinger Britt A., In PLoS Pathogens, 2005
... Antibodies against SC-35, Flag, Myc and Aly (Sigma), GFP and mCherry (Clontech), B23 (Santa Cruz), KSHV ...
Phosphate-binding tag, a new tool to visualize phosphorylated proteins
Moens Ugo et al., In Cellular and Molecular Life Sciences, 2005
... Phospho-PKA substrate (RRXS/T) antibody and Myc-tag Alexa Fluor 647 conjugate mouse monoclonal antibody were obtained from Cell Signaling (catalogue number 9624 and ...
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB.
Wu Gen Sheng, In PLoS ONE, 2005
... Goat polyclonal mTOR (FRAP; N-19) and mouse monoclonal c-Myc (9E10) antibodies were purchased from Santa Cruz Biotechnology, Inc ...
Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster.
Oshima Robert, In PLoS ONE, 2005
... , Santa Cruz Biotechnology, Santa Cruz, CA, USA); rabbit polyclonal antibodies for c-Myc (Cell Signaling, ck USA), low molecular ...
Differentiation of mesenchymal stem cells transplanted to a rabbit degenerative disc model: potential and limitations for stem cell therapy in disc regeneration
Sakai Daisuke et al., In Arthritis Research & Therapy, 2004
... Polyclonal rabbit antibodies against rat p15 INK4b, p21 WAF1/Cip1 and c-Myc were from Abcam (Cambridge, UK) and monoclonal ...
TRAF6-mediated ubiquitination regulates nuclear translocation of NRIF, the p75 receptor interactor.
Koritzinsky Marianne, In PLoS ONE, 2004
... nCLU (B5), HA, Myc and His antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Gefitinib (“Iressa”, ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor, reverses breast cancer resistance protein/ABCG2-mediated drug resistance.
Cobine Paul, In PLoS ONE, 2004
... Monoclonal antibody BXP-21 against ABCG2, anti-Myc and anti-HA antibodies were from ID Labs, Cell Signaling, and Roche, respectively ...
The Syk tyrosine kinase localizes to the centrosomes and negatively affects mitotic progression
Geahlen RL et al., In Oncogene, 2004
... Similarly, full-length TRIP cDNA was cloned into the pCMV-Myc vector (BD Biosciences) for expressing Myc-tagged TRIP ...
Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways.
Fernandez-Funez Pedro, In PLoS ONE, 2004
... I sites of the mammalian expression vector pCMV-MYC (Clontech; Mountain View, USA) ...
SUMO modification of heterogeneous nuclear ribonucleoproteins
Gehring Heinz et al., In Sarcoma, 2003
... Finally, the His-GFP-Zf and His-GFP-Zf(Y656A) vectors were constructed by amplification of the His-GFP fragment from EWS-Myc-6xHis/pEGFP-N2, a derivative of pEGFP-N2 plasmid (Clontech) using the NheI-His-forward and ...
Molecular beacons
Kojima Masami et al., In Molecular Brain, 2003
... The anti-BDNF (N-20) and anti-c-Myc (9E10) were from Santa Cruz Biotechnology (Santa Cruz, CA); the ...
Phosphatidylinositol-4,5-bisphosphate hydrolysis directs actin remodeling during phagocytosis
Grinstein Sergio et al., In The Journal of Cell Biology, 2003
... Rabbit polyclonal antibodies to c-Myc (A-14) were purchased from Santa Cruz Biotechnology, Inc ...
K+ channel interactions detected by a genetic system optimized for systematic studies of membrane protein interactions.
Pearson Christopher E., In PLoS Genetics, 2003
... Santa Cruz Biotechnology); rabbit polyclonal anti-pan 14-3-3 (SA-483, Biomol); mouse monoclonal anti-HA (12CA5, Sigma) and anti-Myc (9E10, Santa Cruz Biotechnology); rabbit polyclonal anti-Rad53 (a ...
A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol
Salic Adrian et al., In The Journal of Cell Biology, 2003
... MA), epoxomicin (Enzo Life Sciences, Inc.), diamide (TCI America), rat anti-HA antibody (3F10; Roche), mouse anti-Myc antibody (9E10; Roche), rabbit antiubiquitin antibody (Enzo Life Sciences, Inc.), rabbit anticalnexin antibody (Abcam), rabbit antigigantin antibody (Abcam), ...
A nuclear FK506-binding protein is a histone chaperone regulating rDNA silencing.
Geraghty Robert J., In PLoS ONE, 2003
... and resolved by SDS-PAGE followed by immunoblot assay for detection using anti-c-Myc antibody (BD Biosciences) and goat anti-mouse IgG-HRP ...
Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-α induction
Akira Shizuo et al., In The Journal of Experimental Medicine, 2003
... library (CLONTECH Laboratories, Inc.), digested with appropriate restriction enzymes, and inserted into pFLAG–CMV2 (Sigma-Aldrich) or pCMV-Myc (CLONTECH Laboratories, Inc.) ...
MATCH: A tool for searching transcription factor binding sites in DNA sequences
Borlak Jürgen et al., In BMC Systems Biology, 2002
... Transcription profiling of lung adenocarcinomas of female c-Myc-transgenic mice: 477 significantly regulated ...
Acute antinociceptive responses in single and combinatorial opioid receptor knockout mice: distinct mu, delta and kappa tones
Panula Pertti et al., In BMC Neuroscience, 2002
... Mouse monoclonal anti-c-MYC antibody 9E10 and the c-MYC blocking peptide were from Sigma-Aldrich, rabbit polyclonal anti-c-MYC 9E10 antibody was from Santa Cruz Biotechnologies (Santa Cruz, California, USA), rabbit polyclonal C-terminal and N-terminal anti-NPFF2R antibodies and blocking peptides from Novus Biologicals (Littleton, CO, USA), rabbit ...
Phorbol ester stimulates the nonhypoxic induction of a novel hypoxia-inducible factor 1alpha isoform: implications for tumor promotion.
Bauer Joseph Alan, In PLoS ONE, 2002
... Antibodies against GFP, phospho(Ser439)-MLCK, Myc-epitope, β-tubulin, and horseradish peroxidase-conjugated secondary antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions.
Katoh Masaru, In PLoS ONE, 2002
... anti-E-cadherin from BD Biosciences (San Diego, CA), anti-N-cadherin from Epitomics (Burlingame, CA), anti-Snail (ab85931), anti-cytokeratin, anti-MYC and anti-GFP from Abcam (Cambridge, MA), anti-pMOTIF (PKD ...
Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning
Walker Cheryl Lyn et al., In The Journal of Cell Biology, 2002
... The following antibodies were used: tuberin, hamartin, lamin A/C, HA, and Myc (Santa Cruz Biotechnology, Inc.); Rheb, phosphotuberin (T1462), ...
Summaries of Affymetrix GeneChip probe level data.
Thiel Volker, In PLoS ONE, 2002
... affinity purification and immunoprecipitation: Rabbit IgG Sepharose (Sigma Aldrich), UltraLink Immobilized Streptavidin Plus Gel (Pierce), Anti-Myc Agarose (Sigma Aldrich), Anti-HA Agarose (Sigma Aldrich) ...
A comparison of normalization methods for high density oligonucleotide array data based on variance and bias
Flotte Terence R et al., In Molecular Therapy, 2002
... Plates were coated with a c-Myc antibody (1:1,000 diluted Goat anti-c-Myc; Abcam), plates were then blocked ...
TM4: a free, open-source system for microarray data management and analysis.
Abdelhay Eliana Saul Furquim Werneck, In PLoS ONE, 2002
... 30 µL MYC antibody (Abcam, Cambridge, MA) with 40 ...
SUMOylation of the MAGUK protein CASK regulates dendritic spinogenesis
Hsueh Yi-Ping et al., In The Journal of Cell Biology, 2001
... Myc tag monoclonal antibody 9B11 is available from Cell Signaling Technology ...
Locus-specific control of asymmetric and CpNpG methylation by the DRM and CMT3 methyltransferase genes
Lee Jeannie T, In PLoS Genetics, 2001
... Myc-AGO4 plants were transformed with GFP-HYL1 to produce transgenic plants containing both ...
Processing of gene expression data generated by quantitative real-time RT-PCR.
Harhaj Edward, In PLoS ONE, 2001
... Anti-Jak1 antibody was obtained from Upstate Biotechnology (Lake Placid, NY, USA), and anti-Myc tag antibody was purchased from Clontech (Tokyo, Japan) ...
RNase P-mediated inhibition of cytomegalovirus protease expression and viral DNA encapsidation by oligonucleotide external guide sequences.
Zhang Luwen, In PLoS ONE, 2000
... sequences in the pGBKT7 bait and pGADT7 prey plasmids for expression in yeast and in pCMV-Myc and pCMV-HA for expressing in human cells (Clontech, Mountain View, CA) ...
Mnt–Max to Myc–Max complex switching regulates cell cycle entry
Hurlin Peter J. et al., In The Journal of Cell Biology, 2000
... ), anti-Max (Cruz C-17; Santa Cruz Biotechnology, Inc.), and anti c-Myc (N-262; Santa Cruz Biotechnology, Inc.) ...
Spermidine/spermine N1-acetyltransferase specifically binds to the integrin α9 subunit cytoplasmic domain and enhances cell migration
Sheppard Dean et al., In The Journal of Cell Biology, 2000
... mAb 9B11 against the Myc tag was purchased from Cell Signaling Technology ...
Magnitude of the CREB-dependent transcriptional response is determined by the strength of the interaction between the kinase-inducible domain of CREB and the KIX domain of CREB-binding protein.
Uversky Vladimir N., In PLoS ONE, 1999
... pCMV-Myc-hATF1 was constructed by cloning the BC029619 clone from Open Biosystems into the pCMV-Myc vector (Clontech).
MuSK is required for anchoring acetylcholinesterase at the neuromuscular junction
Legay Claire et al., In The Journal of Cell Biology, 1999
... Rabbit polyclonal anti-HA, chicken polyclonal anti-HA, mouse monoclonal anti-Myc, and monoclonal anti-GFP antibodies were purchased from Santa Cruz Biotechnology, Inc., Invitrogen, ICL, and ...
Intranucleolar sites of ribosome biogenesis defined by the localization of early binding ribosomal proteins
Scheer Ulrich et al., In The Journal of Cell Biology, 1999
vector (Invitrogen), sequenced, and subcloned into the following vectors: pEGFP-N1, pEGFP-C1 or -C3, pDsRed-Monomer-N1, pCMV-Myc (all obtained from CLONTECH Laboratories, Inc.), pQ-C-His, and ...
A polyalanine tract expansion in Arx forms intranuclear inclusions and results in increased cell death
Golden Jeffrey A. et al., In The Journal of Cell Biology, 1999
... were individually subcloned in frame with 5′FLAG-, 5′Myc-, 5′GFP- and 3′V5-tagged expression constructs (pCMV-Tag2A (Stratagene), pCMV-Myc and pEGFP-C3 (CLONTECH Laboratories, Inc.), and pCDNA3.1-V5-His
Antisense DNA against calcineurin facilitates memory in contextual fear conditioning by lowering the threshold for hippocampal long-term potentiation induction.
Grant Seth G. N., In PLoS ONE, 1999
... I fragments were isolated from pCaM-activin-Myc or pCaM-follistatin-Myc and microinjected into the pronuclei of one-cell embryos of C57BL/6J mice to produce transgenic mice ...
Cholesterol-dependent clustering of IL-2Ralpha and its colocalization with HLA and CD48 on T lymphoma cells suggest their functional association with lipid rafts.
Buday Laszlo, In PLoS ONE, 1999
... with DAPI: Molecular Probes (Eugene, OR), FuGENE® HD Transfection Reagent: Roche (South San Francisco, CA); pCMV-Myc and pcDNA3.1 V5-His vector: Clontech Laboratories, Inc ...
Munc-18 associates with syntaxin and serves as a negative regulator of exocytosis in the pancreatic beta-cell
Thurmond Debbie C. et al., In The Journal of Cell Biology, 1999
... Protein G plus agarose, mouse anti-Myc, anti-IR, and anti–IR HRP antibodies were purchased from Santa Cruz Biotechnology, Inc ...
Crystal structures of two novel dye-decolorizing peroxidases reveal a beta-barrel fold with a conserved heme-binding motif
Fraaije Marco W. et al., In Applied Microbiology and Biotechnology, 1999
... Antiserum against the Myc sequence was from Abcam.
The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells
Birchmeier Walter et al., In The Journal of Cell Biology, 1998
... Antibodies to Ret9 (C-19-G), Ret51 (C-20), and c-Myc (A14-G) were purchased from Santa Cruz Biotechnology Inc., antibodies to the ...
Improved packing of poly(ethylenimine)/DNA complexes increases transfection efficiency.
Uversky Vladimir N., In PLoS ONE, 1998
... The sequences were subcloned into pCMV-Myc (Clontech) or peGFP-Cx vector (Clontech) ...
A conserved negative regulatory region in alphaPAKinhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1
Chernoff Jonathan et al., In The Journal of Cell Biology, 1997
... Monoclonal antibodies against Myc (9E10) and hemagglutinin (HA; 12CA5) were from Santa Cruz Biotechnology, Inc ...
Regulation of β1-integrin-mediated cell adhesion by the Cbl adaptor protein
Baron Roland et al., In The Journal of Cell Biology, 1997
... Anti–Myc antibody (clone 9E10) was obtained from Santa Cruz Biotechnology, Inc ...
Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
Felsher Dean W et al., In PLoS Biology, 1997
... MYC transgenic line generated for these ...
Cloning and characterization of shk2, a gene encoding a novel p21-activated protein kinase from fission yeast
Chernoff Jonathan et al., In The Journal of Cell Biology, 1997
... Monoclonal anti-hemagglutinin (HA) antibody (12CA5) was obtained from BabCo, polyclonal anti-Myc was obtained from Santa Cruz Biotechnology, Inc. ...
Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7γ
Colombo Emanuela et al., In The Journal of Cell Biology, 1997
... ) using anti-Myc (N-262; Santa Cruz Biotechnology, Inc.) antibodies ...
Modulation of HIV-1 infectivity by MAPK, a virion-associated kinase
Clark Edward A. et al., In The Journal of Experimental Medicine, 1997
... Phospho–c-Myc (Thr58/Ser62) polyclonal antibody was purchased from New England Biolabs ...
Yeast surface display for screening combinatorial polypeptide libraries.
Chin Wei-Chun, In PLoS ONE, 1996
... Surface expression of ephrin-B2 in yeast was measured by immunofluorescence flow cytometry using mouse anti-Myc antibody (9E10, Santa Cruz Biotechnology) followed by goat phycoerythrin-conjugated ...
Regulation of actin polymerization in cell-free systems by GTPγS and Cdc42
Hynes Richard O. et al., In The Journal of Cell Biology, 1996
... The antibody to the c-Myc tag (9E10) was purchased from Santa Cruz Biotechnology ...
Induction of tyrosine phosphorylation and Na+/H+ exchanger activation during shrinkage of human neutrophils
Ju Yu-Ten et al., In Cancer Cell International, 1996
... Mouse anti-c-Myc-antibody (9E10) was obtained from Santa Cruz Biotechnology Inc ...
Analysis of Fgf8 gene function in vertebrate development.
Gonzalez Cayetano, In PLoS ONE, 1996
... The antibodies (Abs) used in this study were as follows: anti-c-Myc (Roche, 1667203, Cell signalling, 2272), anti-HA (Roche, 1867431), PC-2 (Santa Cruz Biotechnology, sc28331); anti-GAPDH (Cell Signalling ...
Type Iγ phosphatidylinositol phosphate kinase modulates adherens junction and E-cadherin trafficking via a direct interaction with μ1B adaptin
Anderson Richard A. et al., In The Journal of Cell Biology, 1996
... pET28 to generate the His-tagged E-cadherin tail or HR–E-cadherin tail, which were then subcloned into pCMV-Myc vector (CLONTECH Laboratories, Inc.) ...
Integrin activation by R-Ras
LaFlamme Susan E. et al., In The Journal of Cell Biology, 1995
... Rabbit and goat polyclonal antibodies to the Myc (9E10) epitope, Flag epitope, and PKCε were purchased from Santa Cruz Biotechnology, Inc ...
Measurement of intracellular pH in cultured cells by flow cytometry with BCECF-AM
Rogers Suzanne et al., In BMC Evolutionary Biology, 1995
... Other antibodies used were obtained as follows: α-c-Myc (clone 9E10) and α-hemagglutinin (HA) (Santa Cruz Biotechnology, Santa Cruz, CA, USA); ...
Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice.
Klefstrom Juha, In PLoS ONE, 1995
... MYC transgenic line generated for these ...
Supervillin modulation of focal adhesions involving TRIP6/ZRP-1
Luna Elizabeth J. et al., In The Journal of Cell Biology, 1995
... The mammalian expression vector pCMV-Myc (BD Biosciences and CLONTECH Laboratories, Inc.) ...
Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA
Wang HongYang et al., In Molecular Cancer, 1995
... Antibodies for Bcl-xL, Bcl-2, Caspase-3, PARP, GAPDH and Myc-tag were from Cell Signaling Technology (CST) ...
Atypical protein kinase C (PKCζ/λ) is a convergent downstream target of the insulin-stimulated phosphatidylinositol 3-kinase and TC10 signaling pathways
Pessin Jeffrey E. et al., In The Journal of Cell Biology, 1995
... and 2 antibodies and the GSK-3α/β antibody were purchased from Transduction Laboratories, and the HA and Myc epitope tag antibodies were purchased from Santa Cruz Biotechnology, Inc ...
Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice
Felsher Dean W et al., In Molecular Cancer, 1995
... The TRE-MYC transgenic lines generated for these ...
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53.
Hofmann Thomas G., In PLoS ONE, 1994
... Mouse monoclonal antibody against Myc-tag was purchased from Cell Signaling.
Growth site localization of Rho1 small GTP-binding protein and its involvement in bud formation in Saccharomyces cerevisiae
Takai Yoshimi et al., In The Journal of Cell Biology, 1993
... The Myc- and His6-tagged protein of l-afadin (Myc-His6-l-afadin) was expressed in High Five insect cells (Invitrogen) infected with the baculovirus bearing the l-afadin cDNA and purified by the use of TALON metal affinity beads (CLONTECH Laboratories, Inc.) ...
Sequence selective double strand DNA cleavage by peptide nucleic acid (PNA) targeting using nuclease S1
Permyakov Eugene A., In PLoS ONE, 1992
... ; immunocytochemistry [ICC], 1/100 dilution; western blot [WB], 1/5000 dilution), rabbit anti-Myc (A14; Santa Cruz Biotech, Heidelberg, Germany; ICC, 1/100), rabbit anti-GCL (Santa Cruz Biotech; WB, 1/1000), rabbit anti-GCL (Sigma Aldrich, Brondby, Denmark; WB, 1/1000), ...
Terminal cisternae of denervated rabbit skeletal muscle: alterations of functional properties of Ca2+ release channels
Goldberg Alfred L. et al., In The Journal of Cell Biology, 1988
... Anti-Myc was purchased from Santa Cruz Biotechnology, Inc., anti-ubiquitin (clone FK2) ...
A metabolite of butylated hydroxytoluene with potent tumor-promoting activity in mouse lung.
Brechbiel Martin W., In PLoS ONE, 1988
... c-Myc transgenic mice were the kind ...
Computed tomographic assessment of radiation induced damage in the lung of normal and WR 2721 protected LAF1 mice
Muñoz-Barrutia Arrate, In PLoS ONE, 1985
... 14 C57BL/6 mice (4 nontransgenic, 4 SPC-raf transgenic, 6 SPC-myc transgenic) were examined using micro-CT ...
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