The transcription factor STAT2 enhances proteasomal degradation of RCAN1 through the ubiquitin E3 ligase FBW7more suppliers
In PLoS ONE, 2011
... The HA, GFP, GST, Hsp90, ubiquitin, α-tubulin, histone H1, and Myc antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Targeting Transcriptional Addictions in Small Cell Lung Cancer with a Covalent CDK7 Inhibitor.
Boston, United States. In Cancer Cell, 08 Jan 2015
Using a high-throughput cellular screen of a diverse chemical library, we observe that SCLC is sensitive to transcription-targeting drugs, in particular to THZ1, a recently identified covalent inhibitor of cyclin-dependent kinase 7. We find that expression of super-enhancer-associated transcription factor genes, including MYC family proto-oncogenes and neuroendocrine lineage-specific factors, is highly vulnerability to THZ1 treatment.
Deconstructing transcriptional heterogeneity in pluripotent stem cells.
More papers using
Boston, United States. In Nature, 04 Jan 2015
Notably, either removal of mature microRNAs or pharmacological blockage of signalling pathways drives PSCs into a low-noise ground state characterized by a reconfigured pluripotency network, enhanced self-renewal and a distinct chromatin state, an effect mediated by opposing microRNA families acting on the Myc/Lin28/let-7 axis.
Discovery of a novel proteasome inhibitor selective for cancer cells over non-transformed cells
In Cell death and differentiation, 2008
... MA), mTOR (Millipore, Temecula, CA), E-cadherin (BD Biosciences, San José, CA), GAPDH (Covance, Princeton, NJ), Myc monoclonal antibody 9E10 (Santa Cruz Biotechnology, Santa Cruz, CA), AlexaFluor594 ... Colocalization
In Neural Development, 2007
... II site of pCMV-Myc (Clontech, Mountain View, California, USA) ... A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol
In The Journal of Cell Biology, 2003
... MA), epoxomicin (Enzo Life Sciences, Inc.), diamide (TCI America), rat anti-HA antibody (3F10; Roche), mouse anti-Myc antibody (9E10; Roche), rabbit antiubiquitin antibody (Enzo Life Sciences, Inc.), rabbit anticalnexin antibody (Abcam), rabbit antigigantin antibody (Abcam), ... Sequence selective double strand DNA cleavage by peptide nucleic acid (PNA) targeting using nuclease S1
In PLoS ONE, 1992
... ; immunocytochemistry [ICC], 1/100 dilution; western blot [WB], 1/5000 dilution), rabbit anti-Myc (A14; Santa Cruz Biotech, Heidelberg, Germany; ICC, 1/100), rabbit anti-GCL (Santa Cruz Biotech; WB, 1/1000), rabbit anti-GCL (Sigma Aldrich, Brondby, Denmark; WB, 1/1000), ...