gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Complement component 6

C-6, complement component C6
C6 is a component of complement cascade. It is part of the membrane attack complex which can insert into the cell membrane and cause cell to lyse. People with C6 deficiency are prone to bacterial infection. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, HAD, CAN, POLYMERASE, CARP
Papers on C-6
[Complement terminal fraction deficiency revealed at first invasive meningococcal infection].
New
Guiddir et al., Bondy, France. In Arch Pediatr, Mar 2015
Secondarily, we highlighted a complete deficiency of complement component C6.
Dietary supplementation with dried chicory root triggers changes in the blood serum proteins engaged in the clotting process and the innate immune response in growing pigs.
New
Berezecka et al., Szczecin, Poland. In J Physiol Pharmacol, Feb 2015
Implementation of the dried chicory roots into the diet of growing pigs caused a significant down-regulation of apolipoprotein C-II complement component C6, C-reactive protein, CD14 antigen, C4b binding protein α and β chains, and fibrinogen.
C6 deficiency does not alter intrinsic regeneration speed after peripheral nerve crush injury.
Baas et al., Amsterdam, Netherlands. In Neurosci Res, 2014
We previously described that deficiency for complement component C6, which prevents formation of the membrane attack complex, slows down degeneration and results in an earlier recovery of sensory function after sciatic nerve injury compared to WT animals.
Complement component C6 deficiency in a Spanish family: implications for clinical and molecular diagnosis.
García-Alonso et al., Murcia, Spain. In Gene, 2013
Complement component C6 deficiency is a genetic disease presenting as increased susceptibility to invasive Neisseria meningitidis infections.
A new haplotype variability in complement C6 is marginally associated with resistance to Aeromonas hydrophila in grass carp.
Li et al., Shanghai, China. In Fish Shellfish Immunol, 2013
The complement component C6 is a constituent of a biochemical cascade that serves as a major effector of the human innate and adaptor immunity, and eliminates infected cells.
Crystal structure of C5b-6 suggests structural basis for priming assembly of the membrane attack complex.
GeneRIF
Liddington et al., Los Angeles, United States. In J Biol Chem, 2012
Crystal structure of C5b-6 suggests structural basis for priming assembly of the membrane attack complex.
Structure of complement C6 suggests a mechanism for initiation and unidirectional, sequential assembly of membrane attack complex (MAC).
GeneRIF
DiScipio et al., Los Angeles, United States. In J Biol Chem, 2012
Structure of complement C6 suggests a mechanism for initiation and unidirectional, sequential assembly of membrane attack complex (MAC).
Complete deficiency of the sixth complement component (C6Q0), susceptibility to Neisseria meningitidis infections and analysis of the frequencies of C6Q0 gene defects in South Africans.
GeneRIF
Potter et al., Cardiff, United Kingdom. In Clin Exp Immunol, 2012
finding of very high serious morbidity in patients with complete C6 deficiency due to meningococcal infections
Association analysis of C6 genetic variations and aspirin hypersensitivity in Korean asthmatic patients.
GeneRIF
Shin et al., Seoul, South Korea. In Hum Immunol, 2011
Genetic polymorphisms in C6 gene do not influence the risk of aspirin hypersensitivity in Korean asthmatic patients.
Molecular cloning, characterization and expression analysis of the complement component C6 gene in grass carp.
Li et al., Shanghai, China. In Vet Immunol Immunopathol, 2011
In this study, we cloned and characterized the grass carp complement component C6 (gcC6) gene.
Involvement of the c-jun N-terminal kinases JNK1 and JNK2 in complement-mediated cell death.
GeneRIF
Fishelson et al., Tel Aviv-Yafo, Israel. In Mol Immunol, 2009
Complement C5b-9 induce a JNK/Bid-dependent and JNK-independent necrotic cell death.
Prevalence of mutations leading to complete C6 deficiency (C6Q0) in the Western Cape, South Africa and detection of novel mutations leading to C6Q0 in an Irish family.
GeneRIF
Orren et al., Cardiff, United Kingdom. In Mol Immunol, 2007
The most common defect, which leads to an increased susceptibility to Neisseria meningitidis infections in the Western Cape, is 879delG.
Protection by meningococcal outer membrane protein PorA-specific antibodies and a serogroup B capsular polysaccharide-specific antibody in complement-sufficient and C6-deficient infant rats.
Käyhty et al., Helsinki, Finland. In Infect Immun, 2006
Complement component C6-deficient (PVG/c-) rats were used to assess the importance of complement-mediated bacterial lysis for protection.
Developmental changes in the fetal pig transcriptome.
Ernst et al., East Lansing, United States. In Physiol Genomics, 2004
Pig cDNAs were identified with homologies to CD3 gamma-subunit, collagen type XIV alpha1, complement component C6, craniofacial developmental protein 1, crystallin-gammaE, DNA binding protein B, epsilon-globin, formin binding protein 2, ribosomal protein L23, small acidic protein, secreted frizzled related protein 2, titin, vitamin D binding protein, and two hypothetical protein products.
Molecular basis for complement component 6 (C6) deficiency in rats and mice.
Stahl et al., Boston, United States. In Immunobiology, 2003
Complement component C6 is a part of the lytic membrane attack complex formed during complement activation.
C6-like and C3-like molecules from the cephalochordate, amphioxus, suggest a cytolytic complement system in invertebrates.
Nonaka et al., Kyoto, Japan. In J Mol Evol, 2002
The deduced amino acid sequence of this molecule is most similar to the primary structure of human complement component C6 and is designated AmphiC6.
High prevalence of complement component C6 deficiency among African-Americans in the south-eastern USA.
Volanakis et al., Birmingham, United States. In Clin Exp Immunol, 2000
Complement component C6 is a part of the membrane attack complex that forms a pore-like structure in cell membranes following complement activation.
Complement component C6 polymorphism: novel protein-typing technique and distribution of allotypes in Germany.
Geserick et al., Berlin, Germany. In Exp Clin Immunogenet, 1999
The genetic polymorphism of human C6 was investigated in Germany using an improved technique: polyacrylamide gel isoelectric focusing and subsequent direct immunofixation with monospecific C6 antisera.
Function of the factor I modules (FIMS) of human complement component C6.
Rushmere et al., Los Angeles, United States. In J Biol Chem, 1999
In order to elucidate the function of complement component C6, truncated C6 molecules were expressed recombinantly.
Reference typing report for complement component C6: protein typing.
Correns et al., Berlin, Germany. In Exp Clin Immunogenet, 1997
Within the C6/C7/C9 Session of the VIIth Complement Genetics Workshop and Conference, various C6 protein allotypes collected from four laboratories were examined using polyacrylamide gel isoelectric focusing (PAGIF) followed by direct immunofixation.
share on facebooktweetadd +1mail to friends