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Heterogeneous nuclear ribonucleoprotein C

C-1, TAP, Fumarate Hydratase, fumarase
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, MHC, fibrillin-1, V1a
Papers using C-1 antibodies
Functional analysis of an individual IFT protein: IFT46 is required for transport of outer dynein arms into flagella
Supplier
Witman George B. et al., In The Journal of Cell Biology, 1974
... ), M-N (M medium without nitrogen), or TAP (Gorman and Levine, 1965) media.Murine IMCD3 cells (CLONTECH Laboratories, Inc.) were grown ...
Papers on C-1
A mechanism of viral immune evasion revealed by cryo-EM analysis of the TAP transporter.
New
Impact
Chen et al., New York City, United States. In Nature, Feb 2016
Intracellular antigenic peptides are transported into the endoplasmic reticulum by the transporter associated with antigen processing (TAP) and then loaded onto the nascent MHC I molecules, which are exported to the cell surface and present peptides to the immune system.
Integrated data analysis reveals uterine leiomyoma subtypes with distinct driver pathways and biomarkers.
New
Aaltonen et al., Helsinki, Finland. In Proc Natl Acad Sci U S A, Feb 2016
In this study, we explored transcriptional differences among leiomyomas harboring different genetic drivers, including high mobility group AT-hook 2 (HMGA2) rearrangements, mediator complex subunit 12 (MED12) mutations, biallelic inactivation of fumarate hydratase (FH), and collagen, type IV, alpha 5 and collagen, type IV, alpha 6 (COL4A5-COL4A6) deletions.
TAP-ing into TIEPPs for cancer immunotherapy.
New
Kiessling, In J Clin Invest, Feb 2016
They demonstrated that TEIPP-specific T cells in TAP-deficient mice have largely been deleted by central tolerance, while the same T cells in WT mice are naive and sustained.
CNS-wide Sexually Dimorphic Induction of the Major Histocompatibility Complex 1 Pathway With Aging.
New
Freeman et al., Beaverton, United States. In J Gerontol A Biol Sci Med Sci, Feb 2016
MHCI components, receptors, associated inflammatory transcripts (IL1α, IL1β, IL6, TNFα), and TAP (transporter associated with antigen processing) components are induced with aging and to a greater degree in female than male mice across CNS regions.
Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma.
New
Impact
Zuna et al., In N Engl J Med, Feb 2016
A CpG island methylator phenotype (CIMP) was observed in a distinct subgroup of type 2 papillary renal-cell carcinomas that was characterized by poor survival and mutation of the gene encoding fumarate hydratase (FH).
Tandem affinity purification of histones, coupled to mass spectrometry, identifies associated proteins and new sites of post-translational modification in Saccharomyces cerevisiae.
New
Pamblanco et al., Burjassot, Spain. In J Proteomics, Feb 2016
The histone chaperone Rtt106p, two members of chromatin assembly FACT complex and Psh1p, an ubiquitin ligase, were the most abundant proteins obtained with both H3-TAP and H4-TAP, regardless of the cell extraction medium stringency.
Genetics of primary bilateral macronodular adrenal hyperplasia: a model for early diagnosis of Cushing's syndrome?
Review
New
Bertherat et al., Paris, France. In Eur J Endocrinol, Oct 2015
Indeed, a limited subset of PBMAH can be observed as part of multiple tumors syndromes due to alterations of the APC, Menin or Fumarate Hydratase genes.
Fumarate in DNA repair.
New
Impact
Lees-Miller, Calgary, Canada. In Nat Cell Biol, Sep 2015
A new study suggests that fumarase, a metabolic enzyme normally associated with ATP production in mitochondria, is recruited to sites of DNA damage where it produces fumarate to inhibit histone demethylation and promote repair of DNA double strand breaks.
Co-evolution with chicken class I genes.
Review
New
Kaufman, Cambridge, United Kingdom. In Immunol Rev, Sep 2015
Chicken tapasin is highly polymorphic, but co-evolution with TAP and class I genes remains unclear.
Coevolution of MHC genes (LMP/TAP/class Ia, NKT-class Ib, NKp30-B7H6): lessons from cold-blooded vertebrates.
Review
New
Flajnik et al., Baltimore, United States. In Immunol Rev, Sep 2015
While coevolution of transporter associated with antigen processing (TAP) and class Ia has been documented in endothermic birds and two mammals, lineages of LMP7 are restricted to ectotherms.
Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation.
New
Impact
Lu et al., Houston, United States. In Nat Cell Biol, Sep 2015
Here, we show that exposure to ionizing radiation induces DNA-PK-dependent phosphorylation of nuclear fumarase at Thr 236, which leads to an interaction between fumarase and the histone variant H2A.Z at DNA double-strand break (DSB) regions.
Identifying novel protein interactions: Proteomic methods, optimisation approaches and data analysis pipelines.
Review
New
Bailey et al., Birmingham, United Kingdom. In Methods, Sep 2015
In this review we summarise a selection of emerging and established techniques currently being applied in this field with a particular focus on affinity-based purification systems and their optimisation, including tandem affinity purification (TAP) tagging, isolation of proteins on nascent DNA (IPOND) and RNA-protein immunoprecipitation in tandem (RIPiT).
Targeting ABL1-mediated oxidative stress adaptation in fumarate hydratase-deficient cancer.
Impact
Linehan et al., Bethesda, United States. In Cancer Cell, 2015
Patients with germline fumarate hydratase (FH) mutation are predisposed to develop aggressive kidney cancer with few treatment options and poor therapeutic outcomes.
Association between TAP1 gene polymorphisms and alopecia areata in a Korean population.
Kim et al., Ch'ŏnan, South Korea. In Genet Mol Res, 2014
The transporter 1 ATP-binding cassette sub-family B (MDR/TAP) gene (TAP1) is located in the major histocompatibility complex class II region, and forms a heterodimer that plays a key role in endogenous antigen presentation pathways.
Analysis of Cell Metabolism Using LC-MS and Isotope Tracers.
Review
Gottlieb et al., Glasgow, United Kingdom. In Methods Enzymol, 2014
These methods were applied in a fumarate hydratase deficient cell model to show how isotope tracing can demonstrate shifts in metabolic pathways and, together with metabolite exchange rates, can be used to gain insights into changes in cell metabolism.
Factor h and properdin recognize different epitopes on renal tubular epithelial heparan sulfate.
GeneRIF
van den Born et al., Groningen, Netherlands. In J Biol Chem, 2012
Factor h and properdin recognize different epitopes on renal tubular epithelial heparan sulfate.
Cells lacking the fumarase tumor suppressor are protected from apoptosis through a hypoxia-inducible factor-independent, AMPK-dependent mechanism.
GeneRIF
Di Renzo et al., Torino, Italy. In Mol Cell Biol, 2012
study found that loss of FH activity conferred protection from apoptosis in normal human renal cells and fibroblasts
A two-dimensional screen for AMPK substrates identifies tumor suppressor fumarate hydratase as a preferential AMPKα2 substrate.
GeneRIF
Schlattner et al., Grenoble, France. In J Proteomics, 2012
AMPKalpha2 is supposed to target the cytosolic/nuclear pools of FH, whose tumor suppressor function relies on DNA damage repair and inhibition of HIF-1alpha-signaling.
Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors.
GeneRIF
Guan et al., Shanghai, China. In Genes Dev, 2012
Tumor-derived FH and SDH mutations accumulate fumarate and succinate, leading to enzymatic inhibition of multiple alpha-KG-dependent dioxygenases and consequent alterations of genome-wide histone and DNA methylation.
Gastric leiomyoma and hyperplastic polyposis coli in a patient with multiple cutaneous and uterine leiomyomatosis.
GeneRIF
Figueiredo et al., Coimbra, Portugal. In J Cutan Med Surg, 2012
Gastric leiomyoma was diagnosed in 38 y/o female MCUL patient on endoscopy performed because of dyspepsia. Routine colonoscopy disclosed hyperplastic polyposis. Testing revealed a previously not reported mutation of the FH gene (c.422G>A, p.Trp141X).
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