Integrated data analysis reveals uterine leiomyoma subtypes with distinct driver pathways and biomarkers.
Helsinki, Finland. In Proc Natl Acad Sci U S A, Feb 2016
In this study, we explored transcriptional differences among leiomyomas harboring different genetic drivers, including high mobility group AT-hook 2 (HMGA2) rearrangements, mediator complex subunit 12 (MED12) mutations, biallelic inactivation of fumarate hydratase (FH), and collagen, type IV, alpha 5 and collagen, type IV, alpha 6 (COL4A5-COL4A6) deletions.
TAP-ing into TIEPPs for cancer immunotherapy.
In J Clin Invest, Feb 2016
They demonstrated that TEIPP-specific T cells in TAP-deficient mice have largely been deleted by central tolerance, while the same T cells in WT mice are naive and sustained.
Fumarate in DNA repair.
Calgary, Canada. In Nat Cell Biol, Sep 2015
A new study suggests that fumarase, a metabolic enzyme normally associated with ATP production in mitochondria, is recruited to sites of DNA damage where it produces fumarate to inhibit histone demethylation and promote repair of DNA double strand breaks.
Analysis of Cell Metabolism Using LC-MS and Isotope Tracers.
Glasgow, United Kingdom. In Methods Enzymol, 2014
These methods were applied in a fumarate hydratase deficient cell model to show how isotope tracing can demonstrate shifts in metabolic pathways and, together with metabolite exchange rates, can be used to gain insights into changes in cell metabolism.