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Tryptase gamma 1

C gamma 1, lung tryptase, A gamma I, gamma 1 gamma 1, skin tryptase
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. There is uncertainty regarding the number of genes in this cluster. Currently four functional genes - alpha I, beta I, beta II and gamma I - have been identified. And beta I has an allelic variant named alpha II, beta II has an allelic variant beta III, also gamma I has an allelic variant gamma II. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha-tryptases predominant. This gene differs from other members of the tryptase gene family in that it has C-terminal hydrophobic domain, which may serve as a membrane anchor. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PLC, CAN, HAD, ACID, tryptase
Papers on C gamma 1
PPARγ antagonist attenuates mouse immune-mediated bone marrow failure by inhibition of T cell function.
Young et al., Bethesda, United States. In Haematologica, Jan 2016
In vitro, bisphenol-A-diglycidyl-ether suppressed activation and proliferation, and reduced phospholipase C gamma 1 and nuclear factor of activated T-cells 1 expression, as well as inhibiting calcium flux in T cells.
Phospholipase C gamma 1 (PLCG1) R707Q mutation is counterselected under targeted therapy in a patient with hepatic angiosarcoma.
Debiec-Rychter et al., Leuven, Belgium. In Oncotarget, Dec 2015
Hepatic angiosarcoma is a rare and aggressive vascular neoplasm.
PLCG1 Gene Mutations in Cutaneous T-Cell Lymphomas Revisited.
Tensen, Leiden, Netherlands. In J Invest Dermatol, Sep 2015
The observation that mutations in the phospholipase C gamma 1 (PLCG1) gene (among which p.S345F was shown to be activating) are frequent (20%) in tumoral cutaneous T-cell lymphoma (CTCL) samples raised the possibility of targeting therapies against the PLCG1 signaling pathway.
Epo-induced erythroid maturation is dependent on Plcγ1 signaling.
Fischer et al., Magdeburg, Germany. In Cell Death Differ, Jun 2015
Here, we demonstrate that phospholipase C gamma 1 (Plcγ1) is activated downstream of EpoR-Jak2 independently of Stat5.
Tryptase is involved in the development of early ventilator-induced pulmonary fibrosis in sepsis-induced lung injury.
Slutsky et al., In Crit Care, 2014
However, protective ventilation attenuated sepsis-induced lung injury and decreased lung tryptase and PAR-2 protein levels.
Activating MET kinase rearrangements in melanoma and Spitz tumours.
Bastian et al., San Francisco, United States. In Nat Commun, 2014
We functionally characterize two of the identified fusion proteins (TRIM4-MET and ZKSCAN1-MET) and find that they constitutively activate the mitogen-activated protein kinase (MAPK), phosphoinositol-3 kinase (PI3K) and phospholipase C gamma 1 (PLCγ1) pathways.
Modulation of TRPA1 thermal sensitivity enables sensory discrimination in Drosophila.
Garrity et al., Waltham, United States. In Nature, 2012
determination of how thermal vs chemical stimuli activating Drosophila TRPA1 are discriminated
Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli.
Julius et al., San Francisco, United States. In Proc Natl Acad Sci U S A, 2011
Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli
TrpA1 regulates thermal nociception in Drosophila.
Penninger et al., Sydney, Australia. In Plos One, 2010
TRPA1 is identified as a conserved regulator of nociception.
Honey bee thermal/chemical sensor, AmHsTRPA, reveals neofunctionalization and loss of transient receptor potential channel genes.
Kadowaki et al., Nagoya, Japan. In J Neurosci, 2010
Honeybee TRPA and Drosophila TRPA1 are functionally comparable in Drosophila as a direct, but not indirect, chemical sensor for insect antifeedants.
TRPA1 mediates mechanical currents in the plasma membrane of mouse sensory neurons.
Stucky et al., Milwaukee, United States. In Plos One, 2009
TRPA1 mediates the Slowly Adapting mechanically-activated currents in small-diameter IB4 negative neurons
New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin.
Li-Weber, Heidelberg, Germany. In Cancer Treat Rev, 2009
The tumor-selectivity of Wogonin has recently been demonstrated to be due to its ability to differentially modulate the oxidation-reduction status of malignant vs. normal lymphocytic cells and to preferentially induce phospholipase C gamma 1, a key enzyme involved in Ca(2+) signaling, through H(2)O(2) signaling in malignant lymphocytes.
Quantitative proteomic assessment of very early cellular signaling events.
Andersen et al., Odense, Denmark. In Nat Biotechnol, 2007
Using this technique, we determined that autophosphorylation of the epidermal growth factor receptor occurs within 1 s after ligand stimulation and is followed rapidly by phosphorylation of the downstream signaling intermediates Src homologous and collagen-like protein and phospholipase C gamma 1.
[Direct involvement of the supraspinal phosphoinositide 3-kinase/phospholipase C gamma 1 pathway in the mu-opioid receptor agonist-induced supraspinal antinociception in the mouse].
Narita, Tokyo, Japan. In Nihon Shinkei Seishin Yakurigaku Zasshi, 2003
In immunohistochemical studies, phosphoinositide 3-kinase (PI3K) was detected in the membrane of the cell soma and the immunoreactivity of PI3K (PI3K-IR) was almost overlapped with MOR-IR and PLC gamma 1-IR in the periaqueductal gray matter (PAG) that is considered to be one of the most important sites for the expression of MOR-mediated antinociception.
Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE.
Snyder et al., Baltimore, United States. In Nature, 2002
Phospholipase C gamma 1 (PLC-gamma 1) hydrolyses phosphatidylinositol-4,5-bisphosphate to the second messengers inositol-1,4,5-trisphosphate and diacylglycerol.
[Phosphoinositide-specific phospholipase C gamma 1--a key protein for signal transduction, triggered by growth factors].
Medvedeva, Saint Petersburg, Russia. In Tsitologiia, 1998
The review is devoted to the participation of phospholipase C gamma 1 in cell signaling.
[Progress of research on tumor suppressor genes].
Kuzumaki, Sapporo, Japan. In Hokkaido Igaku Zasshi, 1996
His321 inhibited phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis by phospholipase C gamma 1 more strongly in vitro than did wild-type gelsolin because of its higher binding capacity to phosphoinositide.
The role of the CD28 receptor during T cell responses to antigen.
Ledbetter et al., Seattle, United States. In Annu Rev Immunol, 1992
CD28 receptor ligation induces tyrosine phosphorylation of specific substrates, including phospholipase C gamma 1, and triggers both calcium-dependent and calcium-independent signals.
Organization of the constant-region gene family of the mouse immunoglobulin heavy chain.
Honjo et al., In Cell, 1982
We have now cloned the entire region (about 200 kilobases) of the constant-region gene family of the immunoglobulin heavy chain, the organization of which is 5'-JH-6.5 kb-C mu-4.5 kb-C delta-55 kb-C gamma 3-34 kb-C gamma 1-21 kb-C gamma 2b-15 kb-C gamma 2a-14 kb-C epsilon-12 kb-C alpha-3'.
CH gene rearrangements in IgM-bearing B cells and in the normal splenic DNA component of hybridomas making different isotypes of antibody.
Cebra et al., In Cell, 1980
To probe mechanisms operating at the CH gene locus during normal B lymphocyte differentiation, we have used cloned probes for the constant region genes Cmu, C gamma 1 and C alpha to analyze the immunoglobulin heavy chain genes of three kinds of cell populations in successive stages of B cell development.
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