BubR1 kinase: protection against aneuploidy and premature aging.
Boston, United States. In Trends Mol Med, Jun 2015
The multidomain protein kinase BubR1 is a central component of the mitotic spindle assembly checkpoint (SAC), an essential self-monitoring system of the eukaryotic cell cycle that ensures the high fidelity of chromosome segregation by delaying the onset of anaphase until all chromosomes are properly bi-oriented on the mitotic spindle.
Prognostic factors of survival rate in oral squamous cell carcinoma: clinical, histologic, genetic and molecular concepts.
Tehrān, Iran. In Arch Iran Med, May 2015
Among well-known molecular markers, cyclin dependent kinase, survivin, CD44, BUBR1, and heat shock proteins (27,70) can be considered as independent prognostic factors of survival rate.
The role of BUB and CDC proteins in low-grade breast cancers.
Nottingham, United Kingdom. In Lancet, Mar 2015
METHODS: The Nottingham Tenovus Primary Breast Cancer Series (n=1858) microarrays were immunostained for BUB (BUB1, BUB1B, BUB3) and CDC proteins (CDC2, CDC42) and expression correlated with clinicopathological and molecular variables and patient outcome (SPSS, version 22).
The dynamic protein Knl1 - a kinetochore rendezvous.
Québec, Canada. In J Cell Sci, 2014
We present emerging roles of the protein interaction motifs present in Knl1, including the RVSF, SILK, MELT and KI motifs, and their role in the recruitment and regulation of the SAC proteins Bub1, BubR1, Bub3 and Aurora B. Finally, we explore how the regions of low structural complexity that characterize Knl1 are implicated in the cooperative interactions that mediate binding partner recognition and scaffolding activity by Knl1.
New insights into the role of BubR1 in mitosis and beyond.
Paris, France. In Int Rev Cell Mol Biol, 2012
BubR1 is a critical component of the spindle assembly checkpoint, the surveillance mechanism that helps maintain the high fidelity of mitotic chromosome segregation by preventing cells from initiating anaphase if one or more kinetochores are not attached to the spindle.
Physiological relevance of cell cycle kinases.
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Madrid, Spain. In Physiol Rev, 2011
Here, we review the physiological relevance of mammalian cell cycle kinases such as cyclin-dependent kinases (Cdks), Aurora and Polo-like kinases, and mitotic checkpoint regulators (Bub1, BubR1, and Mps1) as well as other less-studied enzymes such as Cdc7, Nek proteins, or Mastl and their implications in development, tissue homeostasis, and human disease.