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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

BCL2-associated transcription factor 1

BTF, BCLAF1, BCL-2 associated transcription factor
This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: bcl-2, CAN, HAD, Transferrin, PrP
Papers on BTF
Upregulated SMYD3 promotes bladder cancer progression by targeting BCLAF1 and activating autophagy.
New
Fan et al., Shanghai, China. In Tumour Biol, Jan 2016
Mechanically, SMYD3 positively regulates the expression of BCL2-associated transcription factor 1 (BCLAF1).
[Removal of Waste Gas Containing Mixed Chlorinated Hydrocarbons by the Biotrickling Filter].
New
Chen et al., In Huan Jing Ke Xue, Sep 2015
An experimental investigation on purification of waste gas contaminated with a mixture of dichloromethane (DCM) and dichloroethane(1,2-DCA) was conducted in a biotrickling filter (BTF) inoculated with activated sludge of pharmaceuticals industry.
The expression and prognostic significance of bcl-2-associated transcription factor 1 in rectal cancer following neoadjuvant therapy.
New
Murray et al., Aberdeen, United Kingdom. In Histopathology, Aug 2015
AIMS: bcl-2-associated transcription factor 1 (BCLAF1) is a nuclear protein that binds to bcl-related proteins and can induce apoptosis and autophagy.
Biosynthesis of Resveratrol in Blastospore of the Macrofungus Tremella fuciformis.
New
Guo et al., Guangzhou, China. In Mol Biotechnol, Jul 2015
In this study, a novel bioconversion system was established to produce resveratrol in the blastospore of T. fuciformis (bTf).
Nek5 interacts with mitochondrial proteins and interferes negatively in mitochondrial mediated cell death and respiration.
New
Kobarg et al., Campinas, Brazil. In Cell Signal, Jun 2015
A yeast two-hybrid (Y2H) screen was performed to identify and characterize Nek5 interaction partners and the mitochondrial proteins Cox11, MTX-2 and BCLAF1 were retrieved.
Feedback circuitry between miR-218 repression and RTK activation in glioblastoma.
New
Simon et al., Philadelphia, United States. In Sci Signal, Jun 2015
Mass spectrometry and DNA pull-down identified binding of signal transducer and activator of transcription 3 (STAT3) along with the transcriptional repressor BCL2-associated transcription factor 1 (BCLAF1) directly to the miR-218 locus.
Disruption of SF3B1 results in deregulated expression and splicing of key genes and pathways in myelodysplastic syndrome hematopoietic stem and progenitor cells.
New
Boultwood et al., Pavia, Italy. In Leukemia, May 2015
Many genes regulated by a DNA damage-induced BRCA1-BCLAF1-SF3B1 protein complex showed differential expression/splicing in SF3B1 mutant cases.
Degradation of benzotrifluoride via the dioxygenase pathway in Rhodococcus sp. 065240.
Iwai et al., Yokohama, Japan. In Biosci Biotechnol Biochem, 2014
065240, which catalyzes the defluorination of benzotrifluoride (BTF).
Anticancer effects of β-elemene in gastric cancer cells and its potential underlying proteins: a proteomic study.
Che et al., Xi'an, China. In Oncol Rep, 2014
Among them, expression of p21-activated protein kinase‑interacting protein 1 (PAK1IP1), Bcl-2-associated transcription factor 1 (BTF) and topoisomerase 2-α (TOPIIα) were validated by western blot analyses and the trends were consistent with iTRAQ results.
Using RNA sequencing for identifying gene imprinting and random monoallelic expression in human placenta.
Salumets et al., Tartu, Estonia. In Epigenetics, 2014
The major finding was the identification of 4 genes (ABP1, BCLAF1, IFI30 and ZFAT) with random allelic bias, expressing one of the parental alleles preferentially.
Control of autophagic cell death by caspase-10 in multiple myeloma.
Impact
Staudt et al., Bethesda, United States. In Cancer Cell, 2013
Caspase-10 inhibits autophagy by cleaving the BCL2-interacting protein BCLAF1, itself a strong inducer of autophagy that acts by displacing beclin-1 from BCL2.
BclAF1 restriction factor is neutralized by proteasomal degradation and microRNA repression during human cytomegalovirus infection.
GeneRIF
Murphy et al., Madison, United States. In Proc Natl Acad Sci U S A, 2012
In the absence of BclAF1 neutralization, viral gene expression and replication are inhibited. These data identify two temporally and mechanistically distinct functions used by human cytomegalovirus to down-regulate a cellular antiviral protein
BCLAF1 is a radiation-induced H2AX-interacting partner involved in γH2AX-mediated regulation of apoptosis and DNA repair.
GeneRIF
Chen et al., Chapel Hill, United States. In Cell Death Dis, 2011
BCLAF1 co-localized with gammaH2AX foci in nuclei and stabilized the Ku70/DNA-PKcs complex therein, facilitating non-homologous end joining (NHEJ)-based DSB repair in surviving cells.
The LINC complex and human disease.
Review
Wehnert et al., Greifswald, Germany. In Biochem Soc Trans, 2011
EDMD-causing mutations in STA/EMD (encoding emerin) that disrupt emerin binding to Btf (Bcl-2-associated transcription factor), GCL (germ cell-less) and BAF (barrier to autointegration factor) provide the first glimpses into LINC being involved in gene regulation and thus opening new avenues for functional studies.
The type III histone deacetylase Sirt1 protein suppresses p300-mediated histone H3 lysine 56 acetylation at Bclaf1 promoter to inhibit T cell activation.
GeneRIF
Fang et al., Chicago, United States. In J Biol Chem, 2011
Sirt1 negatively regulates T cell activation via H3K56 deacetylation at the promoter region to inhibit transcription of Bclaf1
Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma.
GeneRIF
Cerhan et al., Rochester, United States. In Cancer Epidemiol Biomarkers Prev, 2010
We replicated the association of BCL2L11 and CASP9 with non-Hodgkin's lymphoma risk at the gene and SNP level, and identified novel associations with BCLAF1 and BAG5.
In search of a function for BCLAF1.
Review
GeneRIF
McPherson et al., Toronto, Canada. In Scientificworldjournal, 2009
Findings indicate a role for BCLAF1 in post-transcriptional processes that impact mRNA metabolism.
Tandem array-based expression screens identify host mRNA targets of virus-encoded microRNAs.
Impact
Ganem et al., San Francisco, United States. In Nat Genet, 2009
Using this strategy, we identified BCLAF1, encoding Bcl2-associated factor, as a target for miR-K5, and further analysis revealed that several other KSHV miRNAs also target this gene product.
Systematic discovery of in vivo phosphorylation networks.
Impact
Pawson et al., Toronto, Canada. In Cell, 2007
We describe a scalable strategy to evaluate predictions, which suggests that BCLAF1 is a GSK-3 substrate.
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