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Bone marrow stromal cell antigen 2

BST2, CD317, Tetherin, HM1.24 antigen
Bone marrow stromal cells are involved in the growth and development of B-cells. The specific function of the protein encoded by the bone marrow stromal cell antigen 2 is undetermined; however, this protein may play a role in pre-B-cell growth and in rheumatoid arthritis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, CD4, m-1, V1a, S-100
Papers using BST2 antibodies
ZAP-70 kinase regulates HIV cell-to-cell spread and virological synapse formation.
Supplier
Luban Jeremy, In PLoS Pathogens, 2006
... and CEM cells were electroporated (BioRad Gene pulser) with pRS-TI357703, coding for a 29-mer shRNAs targeting BST2 mRNA, or pRS expressing an off-target control (OriGene) ...
One step screening of retroviral producer clones by real time quantitative PCR.
Supplier
Jung Jae U., In PLoS Pathogens, 1998
... monoclonal antibody HA1.11 was obtained from Covance, rabbit anti-HA polyclonal was obtained from Rockland and anti-BST2 monoclonal antibody was obtained from Abnova.
Papers on BST2
The disulfide bonds within BST-2 enhance tensile strength during viral tethering.
New
Berndsen et al., In Biochemistry, Feb 2016
UNASSIGNED: Human BST-2/tetherin is a host factor that inhibits release of enveloped viruses, including HIV-1, HIV-2, and SIV, from the cell surface by tethering viruses to the host cell membrane.
Filamin A Is Involved in HIV-1 Vpu Mediated Evasion of Host Restriction by Modulating Tetherin Expression.
New
Dong et al., United States. In J Biol Chem, Feb 2016
UNASSIGNED: Tetherin, also known as bone marrow stromal antigen 2 (BST-2), inhibits the release of a wide range of enveloped viruses including HIV-1 by directly tethering nascent virions to the surface of infected cells.
ATP1B3 Modulates the Restriction of HIV-1 Production and of NF-κB Activation by BST-2.
New
Takaku et al., Japan. In J Biol Chem, Jan 2016
UNASSIGNED: Here, we identify ATP1B3 and fibrillin-1 as novel BST-2-binding proteins.
Pharmacologic Inhibition of Nedd8 Activation Enzyme Exposes CD4-induced Epitopes within Env on Cells Expressing HIV-1.
New
Guatelli et al., San Diego, United States. In J Virol, Jan 2016
UNASSIGNED: HIV-1 Vpu decreases the exposure of epitopes within the viral envelope glycoprotein (Env) on the surface of infected cells by downregulating both BST2 and CD4.
Human parainfluenza virus type 2 V protein inhibits and antagonizes tetherin.
New
Nishio et al., In J Gen Virol, Jan 2016
UNASSIGNED: Tetherin (BST-2/CD317/HM1.24) is an antiviral membrane protein that prevents the release of enveloped viruses from the cell surface.
HIV suppression by host restriction factors and viral immune evasion.
Review
New
Xiong et al., New Haven, United States. In Curr Opin Struct Biol, Apr 2015
Here we review the recent developments towards establishing the structural and biochemical bases of HIV inhibition by, and viral countermeasures of, the restriction factors TRIM5, MxB, APOBEC3, SAMHD1, and BST2/tetherin.
Restriction Factors in HIV-1 Disease Progression.
Review
Berthoux et al., Trois-Rivières, Canada. In Curr Hiv Res, 2014
TRIM5α, Mx2/MxB, TRIM22/Staf50, SAMHD1, p21/CDKN1, tetherin/BST2/CD137, APOBEC3G and APOBEC3F have all been proposed to inhibit HIV-1, often with gene variant- or cellular context-specificity.
[Cellular restriction factors that inhibit human immunodeficiency virus replication: new strategies in antiretroviral therapy].
Review
Vázquez-Pérez et al., In Rev Invest Clin, 2014
Conversely, host cells express different proteins like TRIM5a, Tetherin BST-2, as well as cytidine deaminase proteins (APOBEC3) to suppress viral replication.
Targeted therapy for HM1.24 (CD317) on multiple myeloma cells.
Review
Ozaki et al., Tokushima, Japan. In Biomed Res Int, 2013
We have identified that HM1.24 [also known as bone marrow stromal cell antigen 2 (BST2) or CD317] is overexpressed on not only mature MM cells but also MM CSCs.
Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection.
Impact
Malim et al., London, United Kingdom. In Nature, 2013
For the pathogenic retrovirus human immunodeficiency virus type 1 (HIV-1), these include widely expressed restriction factors, such as APOBEC3 proteins, TRIM5-α, BST2 (refs 4, 5) and SAMHD1 (refs 6, 7), as well as additional factors that are stimulated by type 1 interferon (IFN).
[Multifunctional HIV accessory proteins are hub proteins antagonizing host antiviral factors].
Review
Iwatani et al., Nagoya, Japan. In Uirusu, 2012
So far, in addition to Vif-APOBEC3, Vpu-BST-2/Tetherin and Vpx-SAMHD1 have been identified as such examples.
Intrinsic cellular defenses against human immunodeficiency viruses.
Impact
Bieniasz et al., New York City, United States. In Immunity, 2012
Among these are several classes of proteins (APOBEC3, TRIM5, Tetherin, and SAMHD1) that inhibit the replication of human and simian immunodeficiency viruses.
Modulation of hepatitis C virus release by the interferon-induced protein BST-2/tetherin.
GeneRIF
Taube et al., Beersheba, Israel. In Virology, 2012
BST-2 moderately restricts HCV production and release from Huh-7.5 hepatocytes.
Dimerization of the transmembrane domain of human tetherin in membrane mimetic environments.
GeneRIF
Sharpe et al., Toronto, Canada. In Biochemistry, 2012
In the absence of the coiled-coil domain, the transmembrane domain of human tetherin forms parallel homodimers in membrane mimetic environments.
Influenza virus partially counteracts restriction imposed by tetherin/BST-2.
GeneRIF
Piguet et al., Cardiff, United Kingdom. In J Biol Chem, 2012
Influenza virus partially counteracts restriction imposed by tetherin/BST-2
A single nucleotide polymorphism in tetherin promotes retrovirus restriction in vivo.
GeneRIF
Santiago et al., Aurora, United States. In Plos Pathog, 2011
A single nucleotide polymorphism in tetherin promotes retrovirus restriction in vivo.
Expression analysis of LEDGF/p75, APOBEC3G, TRIM5alpha, and tetherin in a Senegalese cohort of HIV-1-exposed seronegative individuals.
GeneRIF
Van Ostade et al., Antwerp, Belgium. In Plos One, 2011
increased tetherin levels could be a marker of advanced HIV disease.
Tetherin: holding on and letting go.
Impact
Kirchhoff et al., Ulm, Germany. In Cell, 2010
This Essay discusses the host restriction factor tetherin, which blocks the release of enveloped viruses like HIV-1, and the factors evolved by primate lentiviruses, such as Vpu and Nef, that antagonize tetherin's action.
Tetherin is as tetherin does.
Impact
Spearman et al., Atlanta, United States. In Cell, 2009
Tetherin is a cellular restriction factor that inhibits the release of HIV and other enveloped viruses from host cells.
Tetherin inhibits HIV-1 release by directly tethering virions to cells.
Impact
GeneRIF
Bieniasz et al., New York City, United States. In Cell, 2009
Study demonstrates, through mutational analyses and domain replacement experiments, that tetherin configuration rather than primary sequence is critical for antiviral activity.
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